A5042866835- MicroRNA in disease regulation
- Cardiac Valve Diseases and Treatments
- Circular RNAs in diseases
- Cardiac Ischemia and Reperfusion
- Electrospun Nanofibers in Biomedical Applications
- Receptor Mechanisms and Signaling
- Cancer-related molecular mechanisms research
- Congenital Heart Disease Studies
- Head and Neck Surgical Oncology
- Tissue Engineering and Regenerative Medicine
- Cardiac Fibrosis and Remodeling
- Meningioma and schwannoma management
- Mechanical Circulatory Support Devices
- Renin-Angiotensin System Studies
- Brain Metastases and Treatment
- RNA Research and Splicing
- Aortic Disease and Treatment Approaches
- Urinary Bladder and Prostate Research
- Pituitary Gland Disorders and Treatments
- Transplantation: Methods and Outcomes
- GDF15 and Related Biomarkers
- Neuropeptides and Animal Physiology
- Management of metastatic bone disease
- Abdominal Trauma and Injuries
- Abdominal Surgery and Complications
Cairo University
2023
Harvard University
2011-2023
Boston Children's Hospital
2012-2023
Al-Azhar University
2020-2021
Bahçeşehir University
2019
Augusta University
2015-2018
Augusta University Health
2018
Beth Israel Deaconess Medical Center
2015-2017
Center for Vascular Biology Research
2017
Boston Children's Museum
2012
The nonselective β-adrenergic receptor antagonist (β-blocker) carvedilol has been shown to protect against myocardial injury, but the detailed underlying mechanisms are unclear. We recently reported that stimulates processing of microRNA (miR)-199a-3p and miR-214 in heart via β-arrestin1-biased β1-adrenergic (β1AR) cardioprotective signaling. Here, we investigate whether these β-arrestin1/β1AR-responsive miRs mediate beneficial effects simulated ischemia/reperfusion (sI/R). Using cultured...
Acute myocardial infarction (MI) leads to cardiac remodelling and development of heart failure. Insufficient capillary density after MI is considered a critical determinant this process. MicroRNAs (miRs), negative regulators gene expression, have emerged as important players in MI. We previously showed that miR-532-5p (miR-532) up-regulated by the β-arrestin-biased β-adrenergic receptor antagonist (β-blocker) carvedilol, which activates protective pathways independent G protein-mediated...
Abstract Introduction Traditionally, exploratory laparotomy was used to treat penetrating abdominal trauma (PAT). At present, minimally invasive surgery (for diagnostic and therapeutic purposes) has developed represents a rapidly evolving modality for dealing with PAT in stable children. In this article, we aim present our experience, evaluate the effectiveness, report results of (MIS) pediatric patients. Materials Methods This prospective study involved 117 hemodynamically cases (caused by...
Chronic treatment with the β-blocker carvedilol has been shown to reduce established maladaptive left ventricle (LV) hypertrophy and improve LV function in experimental heart failure. However, detailed mechanisms by which improves failure are incompletely understood. We previously showed that is a β-arrestin-biased β1-adrenergic receptor ligand, activates cellular pathways independent of G protein-mediated second messenger signaling. More recently, we have demonstrated microRNA (miR)...
Abstract In pursuit of a suitable scaffold material for cardiac valve tissue engineering applications, an acellular, electrospun, biodegradable polyester carbonate urethane urea (PECUU) was evaluated as pulmonary leaflet replacement in vivo . sheep ( n = 8), single replaced with PECUU and followed 1, 6, 12 weeks. Implanted function assessed by echocardiography. Explanted samples were studied gross pathology, microscopic changes the extracellular matrix, host cellular re‐population, immune...
The death rate from cancer in the USA has declined steadily over past 2 decades (1). Improved survival associated with anticancer agents led to a greater recognition of late effects cardiotoxicity including left ventricular dysfunction, heart failure and coronary disease.
Background: Urethral catheterization is very common, considered a minor procedure done by physicians and well-trained nurses. However, in some traumatic or congenital cases, male problematic. A multitude of techniques are available still can utilize the natural urethral opening to manage this distressing situation. Among these techniques, cystoscopic-assisted retrograde railroad reliable options. This article aimed document application evaluate outcomes both for problematic catheterization....
Background and aims: Tumors involving the calvarium but extending into adjacent scalp layers and/or underlying dura brain are technically challenging to treat.Patients often present late in course of disease which results either irresectable tumor configurations or -if at all feasible-the need for complex resections, latter allograft cranioplasty duraplasty sometimes combination with skin grafting repair surgical defects.This multidisciplinary study evaluates outcome single stage resections...
Myocardial infarction (MI) leads to cardiac remodeling and development of heart failure. Insufficient myocardial capillary density after MI has been identified as a critical event in this process. MicroRNAs (miRs), negative regulators gene expression, have emerged important players diseases including MI. We previously showed that miR-532-5p (miR-532) is up-regulated by the β-arrestin-biased β-blocker carvedilol (Carv), which activates protective pathways independent G protein-mediated second...
MicroRNAs (miRs) are small non-coding RNAs that post-transcriptionally regulate target genes. First transcribed as primary miR transcripts (pri-miRs), they enzymatically processed in the nucleus by Drosha into hairpin-shaped premature miRs (pre-miRs) and further cytoplasm Dicer mature miRs. MiRs cellular processes upon activation various signals such those stimulated β-adrenergic receptors (βARs). Initially discovered to desensitize βAR signaling, β-arrestins now appreciated diverse effector...
Pulmonary valve (PV) replacement surgery is a treatment option for patients with congenitally defective pulmonary outflow track. A tissue engineered (TEPV) potential approach to serve as pediatric heart that has the somatic growth. The single leaflet surgical model can assist in assessing candidate biomaterials responses in-vivo function. However, an empirically determined unloaded shape may result abnormal function due incomplete coaptation of leaflets and asymmetric stress distributions....
Tissue engineered pulmonary valve (TEPV) has been suggested as a potential approach for replacement congenitally defective pediatric heart valves. As with all valves, the leaflet shape during systole and diastole is essential to normal function of PV. In this work, we present design framework on optimal unloaded TEPV single surgery by incorporating key experimental data within finite element (FE) simulation framework. The mechanical properties material are measured biaxial tensile flexural...