A5039372939- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Education
- Diabetes Treatment and Management
- Cardiovascular Disease and Adiposity
- Obesity, Physical Activity, Diet
- Eating Disorders and Behaviors
- Pain Mechanisms and Treatments
- Metabolism, Diabetes, and Cancer
- Digestive system and related health
- Neuroendocrine Tumor Research Advances
- Cardiovascular Health and Disease Prevention
- Health and Lifestyle Studies
- Health and Wellbeing Research
- Diet and metabolism studies
- Parkinson's Disease Mechanisms and Treatments
- Genomic variations and chromosomal abnormalities
- Medication Adherence and Compliance
- Sleep and related disorders
- Glycogen Storage Diseases and Myoclonus
- Genetics and Neurodevelopmental Disorders
- Diabetic Foot Ulcer Assessment and Management
- Glycosylation and Glycoproteins Research
Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione
2010-2021
Pontifical Catholic University of Rio de Janeiro
2009-2017
Universidade Católica de Brasília
2011
Leicester General Hospital
1978
University of Freiburg
1923
Comorbid depression in diabetes has been suggested as one of the possible causes an inadequate glycemic control. The purpose this study was to investigate association between major and control type 2 mellitus (T2DM).Seventy T2DM patients were evaluated. They underwent a psychiatric examination using following instruments: Structured Clinical Interview for DSM-IV Beck Depression Inventory. status assessed short-term (glycemia, glycated hemoglobin) clinical control.The presence current...
BACKGROUND: A few studies have shown high rates of eating disorders and psychiatric morbidity in patients with type 2 diabetes mellitus. OBJECTIVE: disturbed behavior comorbidity a sample T2DM patients. METHODS: Seventy mellitus between 40 65 years age (mean, 52.9 ± 6.8) from outpatient clinic were sequentially evaluated. The Structured Clinical Interview for DSM-IV, Binge Eating Scale Beck Depression Inventory used to assess other comorbidity. In addition the descriptive analysis data, we...
Peripheral Diabetic Neuropathy (PDN) and cognitive impairment are complications of Diabetes Mellitus (DM) that seem to share several underlying mechanisms. The aim this study was investigate whether diabetic patients would have worse function than non individuals within patients, those with PDN present an even more significant impairment.Ninety four (94) outpatients Type 2 DM were sequentially evaluated. Also, Fifty (54) healthy selected match the group. For assessment neuropathy, Portuguese...
This study aimed to evaluate the occurrence and clinical predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM.The included 45 diabetes mellitus (DM) (aged 36 ± 9 years) who underwent carotid Doppler ultrasound evaluation determine artery intima-media thickness (CIMT) assess plaques. Insulin sensitivity was assessed by estimated glucose disposal rate (eGDR), metabolic syndrome (MS) defined World Health Organization criteria.The cohort had a mean age...
OBJECTIVE: Our aim was to determine the relationship between body fat composition, metabolic syndrome (MS), and insulin resistance in type 1 diabetes (DM1). SUBJECTS AND METHODS: Forty-five DM1 women (36 ± 9 years; mass index 24.6 4.4 kg/m²) had composition determined by dual-energy X-ray absorptiometry estimated glucose disposal ratio (eGDR), respectively. Twenty patients (45%) MS according World Health Organization (WHO) criteria. RESULTS: Women with increased central lower eGDR than...
Eating behavior is an important aspect related to type 2 diabetes mellitus (T2DM) treatment and may have impact on glycemic control. Previous reports showed elevated prevalence of eating disordered behaviors, especially binge disorder in clinical samples patients. However, results regarding the control T2DM inconsistent. The purpose this study was assess a comorbid (GC) group patients with T2DM.Eating behaviors 70 consecutive were assessed using Structured Clinical Interview for DSM-IV Binge...
OBJETIVO: Avaliar a frequência de síndrome metabólica (SM) em portadores diabetes melito tipo 1 (DMT1) maiores 18 anos, acordo com os critérios da International Diabetes Federation (IDF), do National Cholesterol Education Program (NCEP) e Organização Mundial Saúde (OMS), que foram analisados comparativamente. Secundariamente, verificou-se associação complicações microvasculares, idade, tempo duração controle glicêmico. MÉTODOS: Trata-se estudo transversal 101 pacientes. RESULTADOS: Foram...
The aim of this study was to evaluate how different parameters short-term glycemic control would correlate with the perception health-related quality life (HRQoL) in patients type 1 diabetes mellitus (T1D).A total 50 T1D aged 18 years were evaluated questionnaires Problem Areas Diabetes (PAID) scale and Quality Life (DQOL) measure after 30 days self-monitoring blood glucose (SMBG). Glycemic using glycated hemoglobin (HbA1c), mean levels (MGL) prior month's data from SMBG (Accu-Check 360o),...
Hypoglycemia is a critical and limiting factor of good metabolic control can adversely affect the quality life diabetic patients. The aim study was to evaluate health-related calculate utilities values associated with hypoglycemia in patients type 1 diabetes mellitus (T1DM).A multicenter, cross-sectional observational T1DM from reference centers Brazilian public health system conducted three cities. Demographic clinical data were collected, besides details on frequency severity hypoglycemia....
Objective We aimed to identify the frequency of monogenic diabetes, which is poorly studied in multiethnic populations, due GCK or HNF1A mutations patients with suggestive clinical characteristics from Brazilian population, as well investigate if MODY probability calculator (MPC) could help their selection. Subjects and methods Inclusion criteria were DM diagnosed before 35 years; body mass index < 30 kg/m2; negative autoantibodies; family history two more generations. sequenced 27 seven...
Embora existam recomendações especificas envolvendo o tratamento das dislipidemias em pacientes com alto risco, estas dificilmente são seguidas adequadamente. O objetivo deste estudo é investigar fatores de risco cardiovascular acompanhados ambulatorialmente no Brasil e Venezuela. Os prontuários 412 foram selecionados 4 instituições. divididos conforme a utilização hipolipemiantes. Pacientes sem hipolipemiantes apresentavam níveis mais elevados colesterol total (p< 0,001), LDL 0,001) HDL...
Determine the prevalence of celiac disease in children and adolescents with type 1 diabetes mellitus (DM1) attendance Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione (IEDE).Blood samples were analyzed 120 DM1 from IEDE Clinic for IgA antitissue-transglutaminase antibody dosage seric IgA. Those positive serology guided upper endoscopy small-bowel biopsy to confirm disease.The was 3 patients. The confirmatory all patients, leading a 2.5% studied group.The is increased when...
Zinc transporter 8 autoantibodies (ZnT8A) have been poorly studied in non-Caucasian individuals. We aimed to investigate the prevalence of ZnT8 patients with T1D and their first degree relatives (FDR) from a multiethnic population, as well its relation insulin (INS) or protein tyrosine phosphatase non-receptor 22 (PTPN22) gene polymorphisms.ZnT8A were analyzed sera (n = 72, mean age 30.3 ± 11.4 years) variable duration (15.7 11.8 FDR 78, 18.3 9.1 by triple mix Radioligand Binding Assay (RBA)...
To evaluate serum C-peptide in 88 patients from a multiethnic population with Type-1 diabetes and variable disease durations.Eighty-eight mean duration of 8.1 +7.6 years were included underwent measurement before after glucagon stimulation. Chi-squared Mann Whitney U-tests used to compare the variables between groups (all two-tailed, α = 0.05). Spearmans correlation coefficient was test association continuous variables. Logistic regression for multivariate analysis. Twenty-eight (31.8%)...
Bei der Bildung Nitrite im Speichel dürfte es sich lediglich um durch Oxydase hervorgerufene chemische Vorgänge handeln, wobei Ammonverbindungen teilweise in salpetrigsaure Salze übergeführt werden. Der umkehrbare Prozeß wäre auf den Einfluß Bakterien zurückzuführen. Erwähnt sei noch, daß auch die Art Nahrung Menge Nitritbildung ohne Bedeutung ist. da, wie diesbezügliche Versuche zeigten. Mengen vor und nach Nahrungsaufnahme vorhandenen salpetrigsauren einen kaum nennenswerten Unterschied...
To evaluate the prevalence of pancreatic auto-antibodies (PAb) as well its relationship with HLA DR B1 and PTPN22 polymorphisms in first degree relatives (FDR) Brazilian patients Type 1 diabetes (T1D) multiethnic background.FDR T1D were interviewed blood was sampled for PAb measurement, DRB1 genotyping. Genotyping also performed index cases.In FDR (n=78), 16.7% presented at least one PAb. These individuals had a higher DRB1* 03 than others (p=0.03), without differences While genetic profile...
Patients with type 1 diabetes (T1D) may exhibit some residual insulin secretion for many years after their diagnosis. This has been associated a more favorable prognosis.To analyze in individuals T1D using C-peptide (CP) response to glucagon and comparing patients recent onset (<5 - Group 1) long-standing disease (>5 -Group 2).Subjects had blood sampled before (fasting) 6 minutes infusion CP, HbA1c anti-GAD measurement.Forty-three were evaluated, 22 21 2. Preserved (CP >1.5 ng/mL) was...
The aim of this study was to evaluate if GADA+ and detectable CP had any influence in other autoimmune diseases, glycemic control, risks retinopathy diabetes mellitus type 1 (T1DM) lasting longer than 3 years duration.Fifty T1DM subjects were interviewed, performed fundoscopic examination, measured before after glucagon, HbA1C, GADA.GADA+ (n = 17) a higher frequency diseases when compared GADA (p 0.02). Detectable also associated with prevalence these 0.03), although, not influenced by...