A5003846509- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Viral Infections and Outbreaks Research
- Diabetes Treatment and Management
- Viral Infections and Vectors
- Thyroid Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Viral gastroenteritis research and epidemiology
- Heart Rate Variability and Autonomic Control
- Obesity and Health Practices
- Digestive system and related health
- Transplantation: Methods and Outcomes
- Palliative and Oncologic Care
- Celiac Disease Research and Management
- COVID-19 Clinical Research Studies
- Tryptophan and brain disorders
- Organ Transplantation Techniques and Outcomes
- Blood Pressure and Hypertension Studies
- Bariatric Surgery and Outcomes
- Retinal Diseases and Treatments
- Metabolism, Diabetes, and Cancer
- Mesenchymal stem cell research
Universidade Federal do Rio de Janeiro
2013-2024
Universidade Estadual da Região Tocantina do Maranhão
2024
Hospital Universitário Clementino Fraga Filho
2011-2020
Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione
2009-2013
Hospital São Paulo
2012
Hospital do Rim e Hipertensão
2012
Secretaria Municipal de Saúde
2012
Instituto Nacional do Câncer
2004
Osaka University
1985-1986
The aim of this study is to evaluate the impact diabetes, hypertension, cardiovascular disease and use angiotensin converting enzyme inhibitors/angiotensin II receptor blockers (ACEI/ARB) with severity (invasive mechanical ventilation or intensive care unit admission O2 saturation < 90%) mortality COVID-19 cases.
Abstract Introduction The aim of this study was to evaluate the performance five general severity-of-illness scores (Acute Physiology and Chronic Health Evaluation II III-J, Simplified Acute Score II, Mortality Probability Models at admission 24 hours intensive care unit [ICU] stay), validate a specific score – ICU Cancer Model (CMM) in cancer patients requiring ICU. Methods A prospective observational cohort performed an oncological medical/surgical Brazilian centre. Data were collected...
OBJECTIVE: To evaluate the short term safety and potential therapeutic effect of allogenic adipose tissue-derived stromal/stem cells (ASCs) + cholecalciferol in patients with recent-onset T1D. METHODS: Prospective, phase II, open trial, pilot study which recent onset T1D received ASCs (1x106 cells/kg) 2000UI/day for 3 months (group 1) were compared to controls standard insulin therapy 2). Adverse events, C-peptide (CP), dose, HbA1c, time range (TIR), glucose variability (continuous...
Background There is a lack of information on the clinical and molecular presentation familial partial lipodystrophy (FPLD), rare genetic disorder characterized by subcutaneous fat loss. Objective This study aimed to provide comprehensive assessment clinical, metabolic, features FPLD in Brazilian population. Methods In multicenter cross-sectional investigation we evaluated patients with across five reference centers for lipodystrophies. Diagnosis was made evaluation confirmation. Data...
Newborn rats were inoculated intraperitoneally with haemorrhagic fever renal syndrome (HFRS)-related virus (B-1 strain), and isolation from their various organs was attempted between 1 25 weeks after inoculation. Virus could be isolated repeatedly lung, brain, spleen kidney also peripheral blood. When carried out on fractionated blood cells, associated mainly the macrophage fraction to a lesser extent granulocytes. replicated well in peritoneal exudate cells of normal it grew adherent...
Objective: Adipose tissue-derived stromal/stem cells (ASCs) and vitamin D have immunomodulatory actions that could be useful for type 1 diabetes (T1D). We aimed in this study to investigate the safety efficacy of ASCs + daily cholecalciferol (VIT D) 6 months patients with recent-onset T1D. Materials methods: In prospective, dual-center, open trial, recent onset T1D received one dose allogenic ASC (1 x 106 cells/kg) 2,000 UI/day (group 1). They were compared who chol-ecalciferol 2) standard...
Abstract Aims To investigate if thyroid‐stimulating hormone ( TSH ) levels are associated with any differences in glycaemic control or diabetes‐related complications individuals Type 1 diabetes. Methods This observational, cross‐sectional and multicentre study included patients diabetes for ≥ 5 years, a recent measurement without known previous thyroid disease. Patients were divided into three groups according to levels: 0.4–2.5 mU/l; 2.5–4.4 4.5 mU/l. Results We 1205 mean ± sd age of 23.8...
Binge eating disorder (BED) is the most prevalent in individuals with obesity. Its association factors that control hunger and satiety has not yet been elucidated. We evaluated whether levels of inflammatory markers, frequency psychiatric comorbidities, appetite-related hormones differ between obesity without BED.The Structured Clinical Interview for Diagnostic Statistical Manual Mental Disorders-5 - Clinician Version (SCID-5-CV), Eating Scale, Hospital Anxiety Depression Scale were 39...
Abstract Background Mesenchymal stem cell infusion and vitamin D supplementation may have immunomodulatory actions that could prolong the preservation of residual insulin secretion in patients with type 1 diabetes (T1D). Intervention these agents after onset T1D favor development a remission phase, potential clinical impact. We aimed to compare presence (CR), glycemic control daily requirement at 6, 12, 18, 24 36 months diagnosis using IDAA1c who received therapy adipose tissue-derived...
Summary Newborn (within 24 h after birth), 1-week-old and 6-week-old (adult) rats were inoculated with a Hantaan-related virus (B-1) attempts made to isolate the from various organs. Virus-specific antigens detected in organs of newborn rats. Moreover could be isolated almost all their even 25 weeks infection. In contrast, infected at 6 age but its concentration decreased progressively time. The levels haemagglutination-inhibiting (HI) neutralizing antibodies B-1 sera measured. adult rats,...
Summary Haemagglutinating (HA) antigens of four strains virus related to that causing haemorrhagic fever with renal syndrome (HFRS) were prepared from infected tissue culture fluids by ultracentrifugation. The titres the precipitated increased considerably acetone extraction and sonication. Acetone completely inactivated infectious in antigen preparations. pH-dependent, pH optima at 5.8. Good correlations observed human rat sera between obtained haemagglutination-inhibition (HI) test an...
HbA1c variability has been linked to retinopathy, renal disease and autonomic neuropathy in patients with type 1 diabetes mellitus (T1D) 2 (T2D). Although the same relationship demonstrated for diabetic peripheral (DPN) T2D, data T1D are still lacking.Patients older than 17 years of age ≥ 10 duration follow-up were included. All underwent nerve conduction studies neurological examination. Laboratorial was retrospectively extracted from chart review. Mean (mHbA1c) over calculated, as well...
To assess the frequency and potential influencing factors of remission phase (RP) in Type 1 Diabetes (T1D) as well associations between various criteria used for its definition.
To test the influence of oral fructose and glucose dose-response solutions in blood (BG), glucagon, triglycerides, uricaemia, malondialdehyde postprandial states type 1 diabetes mellitus (T1DM) patients.The study had a simple-blind, randomized, two-way crossover design which T1DM patients were selected to receive (75g sugars dissolved 200 mL mineral-water) two separate days, with 2-7 weeks washout period. In each day, samples drawn after 8h fasting at 180 min obtain glucose, uric acid,...
Zinc transporter 8 autoantibodies (ZnT8A) have been poorly studied in non-Caucasian individuals. We aimed to investigate the prevalence of ZnT8 patients with T1D and their first degree relatives (FDR) from a multiethnic population, as well its relation insulin (INS) or protein tyrosine phosphatase non-receptor 22 (PTPN22) gene polymorphisms.ZnT8A were analyzed sera (n = 72, mean age 30.3 ± 11.4 years) variable duration (15.7 11.8 FDR 78, 18.3 9.1 by triple mix Radioligand Binding Assay (RBA)...
To evaluate serum C-peptide in 88 patients from a multiethnic population with Type-1 diabetes and variable disease durations.Eighty-eight mean duration of 8.1 +7.6 years were included underwent measurement before after glucagon stimulation. Chi-squared Mann Whitney U-tests used to compare the variables between groups (all two-tailed, α = 0.05). Spearmans correlation coefficient was test association continuous variables. Logistic regression for multivariate analysis. Twenty-eight (31.8%)...
Objective Thyroid diseases are common in individuals with type 1 diabetes mellitus (T1DM) and should be investigated annually these individuals. The aim of this study was to evaluate the frequency thyroid first degree relatives (FDR) patients T1DM. Subjects methods Eighty (40 T1DM 40 FDR) were interviewed blood sampled for thyroid-stimulating hormone (TSH), free thyroxine (FT4) peroxidase (TPO) antibodies measurement. Autoantibodies against glutamic acid decarboxylase 65 (GAD65), islet...
Abstract Background Although it is well known in the literature that high triglyceride serum (TG) levels can jeopardize metabolic control, little about influence of low TG on type 1 diabetes patients (T1D). The aim this study to investigate distribution individuals with T1D and its relationship control. Findings We reviewed medical charts 180 T1D, who were classified groups according levels: 1) (below 50 mg/dL); 2) normal (50-150 3) (above 150 mg/dL). 21.1% (n = 38; group 1), 68.6% 123;...
To evaluate safety and therapeutic effect along 12 months of allogenic adipose tissue-derived stromal/stem cells (ASCs) transplantation with cholecalciferol (VITD) in patients recent-onset type 1 diabetes (T1D). Prospective, phase II, open trial, pilot study which recent onset T1D received ASCs (1xKgx106 cells) VITD 2000UI/day for (group 1) were compared to controls standard insulin therapy 2). Adverse events, C-peptide area under the curve (CPAUC), dose, HbA1c frequency FoxP3+ CD4+ or CD8+...