A5066276412- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Cutaneous lymphoproliferative disorders research
- Skin Protection and Aging
- Tumors and Oncological Cases
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Cancer and Skin Lesions
- Acute Ischemic Stroke Management
- Occupational exposure and asthma
- S100 Proteins and Annexins
- Chronic Lymphocytic Leukemia Research
- Infectious Diseases and Mycology
- Medicinal Plants and Neuroprotection
- Neuropeptides and Animal Physiology
- Intramuscular injections and effects
- Retinoids in leukemia and cellular processes
- TGF-β signaling in diseases
- Dermatology and Skin Diseases
- Acute Lymphoblastic Leukemia research
- Medical Case Reports and Studies
- Connective tissue disorders research
- Cancer, Stress, Anesthesia, and Immune Response
- Urban Green Space and Health
- Hypertrophic osteoarthropathy and related conditions
Royal Victoria Hospital
1992-2021
University of Ulster
1992-2021
Belfast Health and Social Care Trust
2014-2021
Royal Victoria Eye and Ear Hospital
1994-2017
Royal Victoria Hospital
2003-2013
Queen's University Belfast
2004-2007
Belfast City Hospital
1996
Royal College of Surgeons in Ireland
1994
Royal Belfast Hospital for Sick Children
1992
Queens University
1991
Plain language summary available online The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for management cutaneous squamous cell carcinoma (cSCC). document aims presented as a detailed review with highlighted practical use in primary, secondary and tertiary care, clinic appropriate skin cancer multidisciplinary team (MDT) meetings (see section 3.0). These may be either local MDTs (LSMDTs) or specialist (SSMDTs), depending on clinicopathological...
Abstract. A radioimmunoassay has been developed and used to measure serum neurone specific enolase (NSE) concentrations in 24 patients, following cerebral infarction. significant correlation between infarct volume maximum NSE concentration was observed ( P = 0·047). Serum also assayed at times 24, 48, 72 96 h post ictus. At a existed levels 0·012), appeared be approaching statistical significance 48 =0·067). No h. In addition of were compared clinical outcome as determined by the Glasgow...
The incidence of skin cancer, both melanoma and nonmelanoma cancer (NMSC), is rising throughout the world. evaluation trends in will allow better planning future development services.Using data collected from Northern Ireland Cancer Registry (NICR), three major cutaneous cancers, basal cell carcinoma (BCC), squamous (SCC) malignant (MM), was determined workload associated with their management assessed.The records patients a first diagnosis BCC, SCC or MM occurring between 1993 2002 were...
Background Beta-blockers have potential antiangiogenic and antimigratory activity. Studies demonstrated a survival benefit in patients with malignant melanoma treated beta-blockers. Objectives To investigate the association between postdiagnostic beta-blocker usage risk of melanoma-specific mortality population-based cohort melanoma. Methods Patients incident diagnosed 1998 2010 were identified within U.K. Clinical Practice Research Datalink confirmed using cancer registry data. death...
278 consecutive patients with suspected contact dermatitis were patch tested the European standard series and gold sodium thiosulfate (0.5% pet.): 13 (4.6%) had a positive allergic response to (GST). All of these female, mean age 37 years. The most frequent site eczema in was head neck (62%). A seborrhoeic distribution common. 46% involvement limbs, 15% perianal or perivulval rash. duration this group 15.8 months. 54% also nickel. Biopsy test reactions GST consistent dermatitis.
Among all 14 500 incident cases of basal cell carcinoma (BCC), 6405 squamous carcinomas (SCC) and 1839 melanomas reported to the Northern Ireland Cancer Registry between 1993 2002, compared with general population, risk new primaries after BCC or SCC was increased by 9 57%, respectively. The subsequent cancer, overall, more than double melanoma.
Follow-up of patients after treatment basal cell carcinoma (BCC) allows for monitoring recurrence and detection new tumours, but adds a significant burden to outpatient clinics. At the skin tumour clinic in dermatology department, Royal Hospitals, Belfast, all are reviewed 2 years surgical excision low-risk primary BCC.An audit was undertaken determine quality data set recorded relating prognostic factors BCCs rate number tumours detected completeness follow-up by patients.Patients who had...
Malignant melanoma is a skin tumour typified by high mortality rates when not diagnosed and excised in its earliest stages. Preoperative diagnostic accuracy may be improved through the development of computerised systems which accurately quantify features indicative this cancer. One such feature boundary contour asymmetry, typically measured across lesion's major minor axes symmetry. In paper techniques for detection lesion asymmetry are discussed, viability integrating Fourier descriptors...
<h3>Abstract</h3> Spinocerebellar Ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disease caused by abnormal expansion of the polyglutamine (polyQ) repeats in ATAXIN1 (ATXN1) protein. Patients with SCA1 suffer from progressive motor and cognitive impairments, without any modifying treatments available. Although mutant ATXN1 expressed throughout brain, cerebellum undergoes most severe degeneration. It remains unclear why particularly vulnerable SCA1. A majority previous...
Two studies were undertaken of patients with dermatological disorders who attended the Accident and Emergency (A&E) Department Royal Belfast Hospital for Sick Children during 1990-1991. The aims to review diagnostic accuracy assess benefits an open-access consultant dermatology clinic. A retrospective survey 14,340 new attendances at A&E department over a 7-month period found that 540 these (4%) had primary disorder. In 26% no diagnosis been made although only 10% referred specialist...
Osteoporosis has been observed with chronic hypervitaminosis A, leading some authors to hypothesize that systemic retinoids may have an effect on bone mineral density. Two previous small studies identified osteoporosis in patients who received long-term therapy etretinate. Etretinate now superceeded by acitretin clinical use. We hypothesized density is lower taking than control cases had never taken acitretin. Thirty Caucasian receiving for a median of 3.6 years variety dermatoses were...
The incidence of cutaneous malignant melanoma has been rising steadily in Caucasian populations for several decades, with a doubling time 10-14 years. An increase about 5% per year reported most since the early 1960s.This study was designed to determine changing primary Northern Ireland and examine changes survival rates from two 5-year periods, 1984-88 1994-98.One thousand three hundred twenty-six patients invasive were included study.The age standardized rate rose 4.3 100,000 population...
Pyoderma gangrenosum (PG) is a painful chronic ulcerative skin disorder often occurring in association with systemic disease. It typically affects the lower limbs, but may also involve other sites, or sometimes develop after trauma of surgical procedures. We report case woman rheumatoid arthritis who developed disfiguring and severe PG right breast, rare site, following biopsy for benign breast lesion, was subsequently successfully treated low-dose cyclosporin A.
Sunbathing and other types of exposure to ultraviolet radiation are the major preventable risk factors for skin cancer. Due continued increase in incidence melanoma Northern Ireland, we have conducted a questionnaire survey an attempt gather information about sunbathing habits forms light amongst Ireland population.The aim this study was examine test-retest reliability used large-scale cross-sectional population pertaining habits, use sun screen, types, frequencies sunburn assess responses...
Malignant melanoma is the deadliest form of skin cancer and must be diagnosed excised during its earliest stages. The development computerised systems which accurately quantify features representative this aims to assist diagnosis improve preoperative diagnostic accuracy. One clinical feature suggestive malignancy asymmetry, considers lesion shape, colour distribution texture. In paper techniques for detection asymmetry are evaluated a new method visually displaying quantifying proposed....
The keratinocyte expression of class II MHC antigens HLA‐DR, DP and DQ was studied in 20 long‐lasting allergic patch test reactions 17 normal tests reactions. No significicant difference the these 2 groups detected. 1 allergen responsible for majority immunological mechanisms which may contribute to are discussed with reference HLA‐DR Keratinocytes.
Two patients with severe disabling psoriasis were treated methotrexate (MTX). As a short course of treatment was envisaged, pretreatment liver biopsy not performed. Although both developed similarly abnormal levels hepatic enzymes after low cumulative doses MTX (440 and 450mg), subsequent biopsies revealed contrasting findings. In one patient the histological features normal. However, in second, there fibrosis, absence led to problems interpretation these histologivcal is by far most...
We previously showed the median duration of positive patch test reactions to nickel sulfate(5% pet) was 9 days, and defined as long‐lasting (LLAPTR) 14.3% that persisted for 17 Days or longer. The pathomechanisms LLAPTR are unclear, but may involve either localized antigen persistence abnormal down regulation cellular immune response. In this study, we compared (a) concentration (b) immunocytochemical nature local reaction, between biopsies from ( n = 8) normally resolving allergic lest...