A5058588599- Metal-Organic Frameworks: Synthesis and Applications
- Anesthesia and Neurotoxicity Research
- Covalent Organic Framework Applications
- Intensive Care Unit Cognitive Disorders
- Polyoxometalates: Synthesis and Applications
- Microstructure and mechanical properties
- Anesthesia and Sedative Agents
- Metallurgy and Material Forming
- Civil and Geotechnical Engineering Research
- Asymmetric Hydrogenation and Catalysis
- Supramolecular Chemistry and Complexes
- Crystallography and molecular interactions
- Aluminum Alloys Composites Properties
- Luminescence and Fluorescent Materials
- Microstructure and Mechanical Properties of Steels
- Electrochemical Analysis and Applications
- Simulation and Modeling Applications
- Shape Memory Alloy Transformations
- Metal and Thin Film Mechanics
- Titanium Alloys Microstructure and Properties
- Cardiac Ischemia and Reperfusion
- Geomechanics and Mining Engineering
- Bacteriophages and microbial interactions
- Antibiotic Resistance in Bacteria
- Plant-based Medicinal Research
Peking University People's Hospital
2024-2025
Shanghai Jiao Tong University
2012-2025
Shanghai Ninth People's Hospital
2019-2025
Peking University
2014-2025
Chengdu University of Traditional Chinese Medicine
2011-2024
Wuhan University
2024
Renmin Hospital of Wuhan University
2024
Cardiovascular Institute Hospital
2024
Ruijin Hospital
2022-2023
Shanghai First People's Hospital
2020-2022
Separation of racemic mixtures is great importance and interest in chemistry pharmacology. Porous materials including metal–organic frameworks (MOFs) have been widely explored as chiral stationary phases (CSPs) resolution. However, it remains a challenge to develop new CSPs for reversed-phase high-performance liquid chromatography (RP-HPLC), which the most popular chromatographic mode accounts over 90% all separations. Here we demonstrated first time that highly stable Zr-based MOFs can be...
Abstract The search for porous materials with strong Brønsted acid sites challenging reactions has long been of significant interest, but it remains a formidable synthetic challenge. Here we demonstrate cage extension strategy to construct chiral permanent hydrogen-bonded frameworks groups heterogeneous asymmetric catalysis. We report the synthesis two octahedral coordination cages using enantiopure 4,4’,6,6’-tetra(benzoate) ligand 1,1’-spirobiindane-7,7’-phosphoric and Ni 4 /Co - p tert...
Interlocked molecular assemblies constitute a captivating ensemble of chemical topologies, comprising two or more separate components that exhibit remarkably intricate structures. The interlocked are typically identical, and heterointerlocked systems comprise structurally distinct remain unexplored. Here, we demonstrate metal-templated synthesis can be exploited to afford not only homointerlocked cage but also cage. Treatment carboxylated 2,9-dimethyl-1,10-phenanthroline (dmp) Cu(I) bis-dmp...
Heterogeneous Brønsted acid catalysts featuring high porosity, crystallinity, and stability have been of great interest for both fundamental studies practical applications, but synthetically, they still face a formidable challenge. Here, we illustrated ligand design strategy directly installing chiral phosphoric into highly stable Zr-MOFs by sterically protecting them from coordinating with metal ions. A pair porous Zr(IV)-MOFs the framework formula [Zr6O4(OH)8(H2O)4(L)2] were prepared...
A key challenge in heterogeneous catalysis is the design and synthesis of catalysts featuring high catalytic activity, selectivity, recyclability. Here we demonstrate that high-performance asymmetric can be engineered from a metal–organic framework (MOF) platform by using ligand strategy. Three porous chiral MOFs with formula [Mn2L(H2O)2] are prepared enantiopure phosphono-carboxylate ligands 1,1′-biphenol functionalized 3,5-bis(trifluoromethyl)-, bismethyl-, bisfluoro-phenyl substituents at...
The design and development of robust porous supported catalysts with high activity selectivity is extremely significant but very challenging for eco-friendly synthesis fine chemicals pharmaceuticals. We report here the highly stable chiral Zr(IV)-based MOFs different topologies to support Ir complexes demonstrate their network structures-dependent asymmetric catalytic performance. Guided by modulated isoreticular expansion strategy, five Zr-MOFs a flu or ith topology are constructed from...
Metal-organic polyhedra featuring non-Archimedean/Platonic architectures with multiple kinds of vertices have aroused great attention for their fascinating structures and properties but are yet challenging to achieve. Here, we report a combinatorial strategy make such nonclassic polyhedral cages by combining kinetically labile metal ions non-planar organic linkers instead the usual only inert centers planar ligands. This facilitates synthesis an enantiopure twisted tetra(3-pyridyl)-based...
Graphene oxide (GO) possessing plenty of hydroxyls and carboxyls is often used in the field biomedicine. To improve its water solubility biocompatibility, 6-armed poly(ethylene glycol) (PEG) was bonded on surface GO sheets via a facile amidation process to form universal drug delivery platform (GO-PEG10K-6arm) with 200 nm size favor enhanced permeability retention effect. Herein, we prepared stable biocompatible GO-PEG10K-6arm under mild conditions characterized chemical structure...
Open AccessCCS ChemistryCOMMUNICATION1 Apr 2022Boosting Enantioselectivity of Chiral Molecular Catalysts with Supramolecular Metal–Organic Cages Dandan Chu, Wei Gong, Hong Jiang, Xianhui Tang, Yong Cui and Yan Liu Chu School Chemistry Chemical Engineering, Frontiers Science Center for Transformative Molecules, State Key Laboratory Metal Matrix Composites, Shanghai Jiao Tong University, 200240 , Gong Jiang Tang *Corresponding author: E-mail Address: [email protected]...
The neurofilament protein light chain (NEFL) is a potential biomarker of neurodegenerative diseases, and interleukin-6 (IL-6) also closely related to neuroinflammation. Especially, NEFL IL-6 are the two most low-abundance known markers neurological making their detection very important for early diagnosis prognosis prediction such kinds diseases. Nevertheless, quantitative low concentrations in serum remains quite difficult, especially point-of-care test (POCT). Herein, we developed...
Open AccessCCS ChemistryRESEARCH ARTICLES2 Sep 2022Planar Chiral [2.2]Paracyclophane-Based Zr(IV) Metal–Organic Frameworks Hong Jiang, Wenqiang Zhang, Bang Hou, Yan Liu and Yong Cui Jiang School of Chemistry Chemical Engineering, Frontiers Science Center for Transformative Molecules, State Key Laboratory Metal Matrix Composites, Shanghai Jiao Tong University, 200240 , Zhang Hou *Corresponding author: E-mail Address: [email protected] https://doi.org/10.31635/ccschem.022.202202285...
Despite existing treatments of generalized myasthenia gravis (gMG), there remains a need for more effective therapies with fewer side effects. Telitacicept, targeting B lymphocyte stimulator (BLyS) and proliferation-inducing ligand (APRIL), emerges as potential novel therapy gMG. In our study, four patients gMG to standard underwent an 8-week course telitacicept monotherapy. Post-treatment, all exhibited satisfactory improvements. The Myasthenia Gravis Foundation America Quantitative...
Determining the crystal structures of covalent organic frameworks (COFs) with atomic precision is pivotal for uncovering their properties and optimizing functionalities. However, synthesis high-quality single crystals COFs suitable X-ray diffraction analysis, especially chiral (CCOFs), remains a formidable challenge. In this work, we report two three-dimensional (3D) CCOFs synthesized via imine condensation tetrahedral tetraamine tetraaldehydes derived from optically active 1,1′-biphenol...
Guided by the coordination-driven self-assembly, four metal–organic cages (MOCs) with <italic>D</italic><sub>2</sub> or <italic>D</italic><sub>4h</sub> symmetry are synthesized and can be efficient catalysts for photocatalytic [2 + 2] cycloaddition reaction.
Abstract Chiral imidodiphosphates (IDPs) have emerged as strong Brønsted acid catalysts for many enantioselective processes. However, the dynamic transformation between O,O ‐ syn and anti conformers typically results in low enantioselectivity. Here we demonstrate that topologies of metal‐organic frameworks (MOFs) can be exploited to control IDP conformations local chiral microenvironments catalysis. Two porous Dy‐MOFs with different are obtained from an enantiopure 1,1′‐biphenol IDP‐based...
Abstract Background The endotracheal tube (ETT) is an essential medical device to secure the airway patency in patients undergoing mechanical ventilation or general anesthesia. However, long-term intubation eventually leads complete occlusion, ETTs potentiate biofilm-related infections, such as ventilator-associated pneumonia. are mainly composed of polyvinyl chloride (PVC), which adheres microorganisms form biofilms. Thus, a simple and efficient method was developed fabricate...
We reported here the self-assembly of two supramolecular structures based on similar trimeric Zn(II) units that are built from novel 2-substituted 8-hydroxyquinoline ligands and coordination ions. The aggregation behavior zinc salt ligand in solution was investigated by a variety techniques, including (1)H NMR, UV-vis photoluminescence (PL). In solid state, can be controlled substituted groups (-NO(2) -F) via intermolecular interaction, such as π···π stacking, C-H···O, C-F···F-C...
Two chiral tubular supramolecular polymers with amplified CPL that can be rationalized by single-crystal X-ray structures are demonstrated.