A5082005073- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Air Quality and Health Impacts
- Global Cancer Incidence and Screening
- Radiation Dose and Imaging
- Carcinogens and Genotoxicity Assessment
- Pesticide Exposure and Toxicity
- Epigenetics and DNA Methylation
- Neuroblastoma Research and Treatments
- Health, Environment, Cognitive Aging
- Radioactivity and Radon Measurements
- Prenatal Screening and Diagnostics
- Lymphoma Diagnosis and Treatment
- Ethics and Legal Issues in Pediatric Healthcare
- Noise Effects and Management
- Climate Change and Health Impacts
- Radiation Therapy and Dosimetry
- Glioma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Economic and Financial Impacts of Cancer
- Health, Medicine and Society
- Chromatin Remodeling and Cancer
- Neonatal Health and Biochemistry
- HIV/AIDS drug development and treatment
- Urban Transport and Accessibility
Inserm
2015-2024
Université Paris Cité
2016-2024
Centre de Recherche Épidémiologie et Statistique
2016-2024
Sorbonne Paris Cité
2016-2024
Hôpital Paul-Brousse
2020-2024
Assistance Publique – Hôpitaux de Paris
2016-2024
Centre de recherche en Epidémiologie et Santé des Populations
2020-2024
Sorbonne Université
2016-2024
Université Sorbonne Paris Nord
2023-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2023
This paper reports the latest survival data for French childhood cancer patients at national level. Data from two National Registries of Childhood Cancer (Haematopoietic Malignancies and Solid Tumours) were used to describe outcomes 15,479 children diagnosed with between 2000 2008 in mainland France. The overall was 91.7% 1 year, 86.9% 2 years 81.6% 5 years. Relative did not differ even infants. Survival lower among infants lymphoblastic leukaemia astrocytoma, but higher neuroblastoma. For...
Childhood leukemia may be associated with traffic-related environmental exposure to benzene, and additional data are needed. The Géolocalisation des Cancers Pédiatriques (GEOCAP) Study, a nationwide French case-control study, was designed avoid selection bias due differential participation misclassification. study compared the 2,760 childhood cases diagnosed in France between 2002 2007 (including 2,275 of acute lymphoblastic (ALL) 418 myeloblastic (AML)) 30,000 contemporaneous child...
Background:Exposures to high-dose ionizing radiation and rate are established risk factors for childhood acute leukemia (AL). The of AL following exposure lower doses due natural background (NBR) has yet be conclusively determined.Methods:AL cases diagnosed over 1990–2009 (9,056 cases) were identified their municipality residence at diagnosis collected by the National Registry Childhood Cancers. Geocap study, which included 2,763 in 2002–2007 30,000 population controls, was used...
Socio-economic status is related to many life style and environmental factors, some of which have been suggested influence the risk childhood cancer. Studies requiring subject participation are usually hampered by selection more educated parents. To prevent such bias, we used unselected nationwide Geographical Information System (GIS)-based registry data, investigate socio-economic disparities on cancer.The Geocap study included all French residents diagnosed with cancer aged up 15 years...
Evaluation of long-term tolerance to antiretroviral exposure during pregnancy is required. An increased risk cancer has been suggested in children exposed utero didanosine.Updated evaluation incidence uninfected nucleos(t)ide reverse transcriptase inhibitors (NRTIs) the French perinatal study born HIV+ mothers, by cross-checking with National Cancer Registry. Associations between and NRTIs were evaluated univariate survival analysis Cox proportional hazard models. Standardized ratios (SIR)...
Background : GEM ® Premier™ 4000 (Instrumentation Laboratory), a new blood gas/CO-Oximeter/hematocrit/electrolyte/glucose/lactate analyzer was evaluated. The only reagents required were disposable cartridges (GEM PAK comprise all components necessary for analysis, including quality controls). Methods evaluation performed in two laboratories according to the Valtec protocol guidelines. Analytical performances (imprecision at three levels, linearity, inaccuracy by method comparison using...
Pesticide exposures are suspected of being a risk factor for several childhood cancers, particularly acute leukemia (AL). Most the evidence is based on self-reported parental domestic use pesticides, but some studies have also addressed associations with agricultural pesticides near place residence.
All nucleoside analogues for treating HIV infection, due to their capacity integrate into and alter human DNA, are experimentally genotoxic some extent. The long‐term oncogenic risk after in utero exposure remains be determined. Cancer incidence uninfected children exposed nucleos(t)ide reverse transcriptase inhibitors (NRTIs) was evaluated, by cross‐checking against the National Registry, French perinatal study of born + mothers. Twenty‐one cancers were identified 15,163 (median age: 9.9...
Abstract Few studies have investigated the seasonal patterns of embryonal tumours. Based on data from French National Registry Childhood Cancers, present study aimed to investigate variations in tumour incidence rates by month birth and diagnosis. The included 6635 primary cases diagnosed before age 15 years over period 2000‐2015 mainland France. Assuming monthly were homogeneous 2000‐2015, we used a Poisson regression model test for overall heterogeneity standardised ratios (SIRs) or scan...
Context and objective.To meet the needs of epidemiological studies exploring impact pesticide exposure in agricultural environment on health, we developed a method to create multi-source crop map for metropolitan France.This was then applied GEOCAP-Agri project risk cancer children.Method.We integrated three data sources -Corine land cover, graphic parcel register, information from BD TOPO ® about vineyards orchards -into geographic system (GIS).The resulting refined by removing...
Abstract Background Domestic and parental occupational pesticide exposures are suspected of involvement in the occurrence childhood acute leukaemia (AL), but role exposure to agricultural activities is little known. In a previous ecological study conducted France, we observed an increase lymphoblastic (ALL) incidence rate with increasing viticulture density municipalities residence at diagnosis. Objectives This aimed test hypothesis that residential proximity croplands birth increases risk...
L'exposition à la pollution de l'air liée au trafic routier est suspectée d'augmenter le risque leucémie aiguë (LA) chez l'enfant. Nous avons testé cette hypothèse l'échelle France métropolitaine, en ciblant fenêtre d'exposition périnatale. L'étude cas-témoins GEOCAP inclut 581 cas LA lymphoblastique (LAL), 136 myéloïde (LAM), nés et diagnostiqués 2010-2015 (Registre national des cancers l'enfant), 11 908 témoins représentatifs naissances domiciliées métropolitaine sur période. La longueur...