A5101742867- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Quantum Dots Synthesis And Properties
- Cancer Cells and Metastasis
- Iron Metabolism and Disorders
National Taiwan University
2015-2018
Cancer stem-like cells play a key role in tumor development, and these are relevant to the failure of conventional chemotherapy. To achieve favorable therapy for colorectal cancer, PEG-PCL-based nanoparticles, which possess good biological compatibility, were fabricated as nanocarriers topoisomerase inhibitor, SN-38. For cancer stem cell therapy, CD133 (prominin-1) is theoretical (CSLC) marker proposed therapeutic target. Cells with overexpression have demonstrated enhanced tumor-initiating...
Apoferritin (AF) is a natural nontoxic iron carrier and has hollow structure that can be used to deliver small molecules. The surface of AF many amine functional groups modified create targeted ligands. We loaded oxaliplatin onto AF, which was then as template conjugate with panitumumab via polyethylene glycol linker. oxaliplatin-loaded conjugated (AFPO) designed specifically target cell lines expressing epidermal growth factor receptor (EGFR). AFPO efficiently released suppressed tumor...
To track nanocarriers, many researches adopt nanocarriers labeled with radiotracers or encapsulating near-infrared fluorescence (NIRF) dye. In this study, novel amphiphilic copolymers, methoxy poly(ethylene glycol) (mPEG)-cyanine-poly(ε-caprolactone) (PCL) (mPEG-Cy-PCL) are synthesized. mPEG-Cy-PCL capable of performing NIRF imaging, photothermal therapy (PTT) on cancer cells and self-assembly nanocarriers. Cy-based micelles can encapsulate doxorubicin (Doxo@Cy-micelle) achieve image-guided...
Recently, nanoparticles (NPs) have been widely investigated for delivery of anticancer drugs. Here, a dual control drug-release modality was developed that uses naturally occurring protein apoferritin loaded with doxorubicin (DOX) and ADS-780 near-infrared (NIR) fluorescent dye-decorated NPs (ADNIR NPs). ADNIR act as grenade to detonate the targeted tumor site following laser irradiation (photothermal therapy, PTT) explode into cluster warheads (apoferritin-loaded DOX nanocages, AF-DOX NCs)...