A5076419899- Nanoparticle-Based Drug Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Traditional and Medicinal Uses of Annonaceae
- Berberine and alkaloids research
- PARP inhibition in cancer therapy
- Insect and Arachnid Ecology and Behavior
- RNA Interference and Gene Delivery
- Quantum Dots Synthesis And Properties
- Radiomics and Machine Learning in Medical Imaging
- Cephalopods and Marine Biology
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanocluster Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Neurobiology and Insect Physiology Research
- Genetic factors in colorectal cancer
- Botanical Research and Chemistry
National Taiwan University
2015-2020
Institute of Physics, Academia Sinica
2010-2012
Cancer stem-like cells play a key role in tumor development, and these are relevant to the failure of conventional chemotherapy. To achieve favorable therapy for colorectal cancer, PEG-PCL-based nanoparticles, which possess good biological compatibility, were fabricated as nanocarriers topoisomerase inhibitor, SN-38. For cancer stem cell therapy, CD133 (prominin-1) is theoretical (CSLC) marker proposed therapeutic target. Cells with overexpression have demonstrated enhanced tumor-initiating...
In the present study, we utilize a poly[2-(N,N-dimethylamino)ethyl methacrylate]-poly(ε-caprolactone) (PDMA-PCL) micellar template-based gold nanoshell as nanocarrier of platinum-based chemotherapeutic drug, dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt). The nanoshells not only function drug delivery platform but also provide remarkable photothermal effect, resulting in synergistically combined chemo-photothermal therapy. With positively charged outstretched hydrophilic PDMA...
// Ying-Hsia Shih 1, 2 , Cheng-Liang Peng Shin-Yu Lee 1 Ping-Fang Chiang Cheng-Jung Yao 5 Wuu-Jyh Lin Tsai-Yueh Luo 2, 4 Ming-Jium Shieh 3 Institute of Biomedical Engineering, College Medicine and National Taiwan University, Nuclear Energy Research, Atomic Council, Taoyuan, Department Oncology, University Hospital Medicine, Radiological Science, Central Division Gastroenterology, Internal Wan Fang Hospital, Taipei Medical Taipei, Correspondence to: Shieh, e-mail: soloman@ntu.edu.tw Luo,...
Resistance of cancer stem cells to radiotherapy remains a major obstacle successful management. Prominin-1 (PROM1) is cell marker. Nanoparticle (NP) chemotherapeutics preferentially accumulate in tumors and are able target stem-like through cell-specific ligands, making them uniquely suited as radiosensitizers for chemoradiation therapy. Using biocompatible apoferritin NP, PROM1-targeted NP carrying irinotecan (PROM1-NP) engineered. The synergistic effect the irradiation evaluated...
Abstract Combined chemo‐photothermotherapy is a novel strategy to improve the therapeutic outcome of cancer treatment by synergistic effects both photothermal therapy (PTT) and chemotherapy. Here, multifunctional gold nanoshells (GNS) that are synthesized using 7‐ethyl‐10‐hydroxycamptothecin (SN‐38)‐loaded micellar template presented. The surface positively charged SN‐38‐encapsulated poly[2‐( N,N ‐dimethylamino)ethyl methacrylate]–poly(ε‐caprolactone) (PDMA–PCL) micelles decorated with layer...
Abstract The pharaoh cuttlefish, Sepia pharaonis , is an important cephalopod fishery species in southeastern Asia, with understudied reproductive physiology. present study aimed to investigate the cellular characteristics of epithelial cells found nidamental glands (NGs) and accessory NGs (ANGs), as well structural connections between these two mature female S. . A histological analysis revealed types NGs: Alcian blue‐positive, PAS‐negative mucosubstance‐secreting eosinophilic, PAS‐positive...
Drug delivery systems combined multimodal therapy strategies are very promising in cancer theranostic applications. In this work, a new drug-delivery vehicles based on human serum albumin (HSA)-coated gold nanorods (GNR/PSS/HSA NPs) was developed. The success of coating verified by transmission electron microscopy (TEM), zeta potential and fourier transform infrared spectroscopy (FTIR). Furthermore, it is demonstrated that doxorubicin (DOX) successfully loaded among multilayered the...
Combined photothermo-chemotherapy is a new strategy for cancer treatment which improves the therapeutic outcome by synergistic effects of both therapies. Here, we presented multifunctional gold nanoshell that exhibited excellent photothermal conversion and delivered hydrophobic chemotherapy drug, SN-38. The positively charged SN-38-loaded PDMA-PCL micelles were decorated with layer in situ reduction chloroauric acid on surface micelles. Scanning transmission electron microscopy images proved...
Gold nanorod's exceptional light to heat transduction is a robust phonomenon that has been extensively verified. The phenomenon trait from which many novel applications across disciplines have proposed. In this investigation, the feasibility of utilizing harvested such photothermal method combat cancer presented. Using non-invasive laser methods, an in vivo study conducted on mouse ear tumors administered with gold nanorods (Au NRs). An emphasis placed monitoring tumor developments after...
P. Californicum (Papaveraceae), fire poppy, is traditionally used against pain. The seed pods were found to contain glycosides of 14-methylnormorphine and papaverine. major alkaloid, ignimorphinan C67H80O19N2, a mixture sterol glycoside dimers second most abundant ignipapaverine C44H55O10N, A possible 2-methoxy-7-hydroxy-6-Omethyl- 7,8-dihydronormorphine-14-carbinol was found. Other compounds myricetin, malvidin-3-Oglucuronide kaempferol acetate. Keywords: Californicum, papaveraceae,...