Microfabrication of dissolvable, swellable, and biodegradable polymeric microneedle arrays (MNs) were extensively investigated based in a nano sensitive fabrication style known as micromilling that is then combined with conventional micromolding technique. The aim this study was to describe the polymer selection, optimize formulation compounding parameters for various MNs. Inverse replication micromilled master MNs reproduced polydimethylsiloxane (PDMS), where solid out plane subsequently...

Mammalian Timeless is a multifunctional protein that performs essential roles in the circadian clock, chromosome cohesion, DNA replication fork protection, and replication/DNA damage checkpoint pathways. The human exists tight complex with smaller called Tipin (Timeless-interacting protein). Here we investigated mechanism by which Timeless-Tipin functions as mediator ATR-Chk1 pathway. We find specifically mediates Chk1 phosphorylation ATR response to stress through interaction of 34-kDa...

Purpose: To determine the effect of extremely low frequency (<300 Hz) electromagnetic fields (ELF-EMF) on growth rate Gram-positive and Gram-negative bacteria to any morphological changes that might have been caused by ELF-EMF. Materials methods: Six bacterial strains, three were subjected 50 Hz, 0.5 mT ELF-EMF for 6 h. after application, exposed 3 h collected, transferred fresh medium cultured without field application another 4 Growth-rate was determined optical density (OD) measurements...

Background The "poke and release" strategy for the delivery of macromolecules using polymeric microneedle (MN) is great importance because it eliminates reuse, risks biohazardous sharps cross contamination, requires no special disposal mechanism. main objective this study was determination stability bovine serum albumin (BSA) that transported across human skin via sodium alginate (SA) arrays (MNs) SA needle free patches two different analytical methods. Methodology Findings capability...

Abstract This study aimed to determine the effect of extremely low‐frequency electromagnetic fields (ELF‐EMF) on physiological response phagocytes an infectious agent. THP‐1 cells (human monocytic leukemia cell line) were cultured and 50 Hz, 1 mT EMF was applied for 4–6 h induced with Staphylococcus aureus or interferon gamma/lipopolysaccharide (IFγ/LPS). Alterations in nitric oxide (NO), inducible synthase (iNOS) levels, heat shock protein 70 levels (hsp70), cGMP caspase‐9 activation,...

The time-course of ELF-EMF application to biological systems is thought be an important parameter determining the physiological outcome. This study investigated effect on differentiation K562 cells at different time courses. (50 Hz, 5 mT, 1 h) was applied two time-courses; first onset hemin induction for h, and second, daily h four days. While single exposure resulted in a decrease differentiation, everyday caused increase differentiation. co-stressors, magnesium, heat-shock also determined...

Quercetin is one of the most abundant dietary flavonoids widely present in many fruits and vegetables. Previous vitro studies has shown that quercetin acts as an antioxidant anti-inflammatory agent it potent anticarcinogenic properties apoptosis inducer. In this study we examined apoptotic effects on K562 erythroleukemia cell line. cells were induced to undergo by hydrogen peroxide. Cell viability level assessed annexin V PI staining methods using flow cytometry. Viability was increased low...

To determine role of human leukocyte antigen (HLA)-G, CD8, CD16, CD56, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α for recurrent miscarriages in feto-maternal interface.Chorion decidua samples were obtained from 11 women with unwanted pregnancies (healthy pregnancy, HP) 10 missed abortion diagnosis after at least two pregnancy losses (recurrent miscarriage, RM). In addition, endometrial tissues non-pregnant (NonP). The expressions markers evaluated using the Western blot analysis....

This study examined the incidence rates of cancer cases (averages for 2006-2010) and relationships with environmental radioactivity levels. Soil water samples were collected from provincial district centers Van city outdoor gamma doses determined using a portable scintillation detector. Gross alpha beta, (226)Ra, (232)Th, (40)K activities measured in both tap soil samples. Although high stomach esophagus cancers have been reported previously underlying reasons not hitherto defined....

Aim: As to clinical examinations, predisposition aggression and aggressive behavior among drivers are very high in Turkey. For this reason, direct correlation between the noise pollution general psychological symptoms with quality of life public transport were investigated survey. Material Methods: Bus varying bus brands (F, O P which has different levels) subjected study. SCL-90-R SF-36 questionnaire used assess presence severity psychiatric life. Sound level meter (Smart Sensor AR844)...

Introduction Noise is defined as unwanted sounds and can cause psychological symptoms such anxiety, restlessness, irritability, sleep disturbances difficulty concentrating. Transportation noise represents a large majority of external that affects people in cities. Professional drivers are the highest risk group. Aim The aim this study to investigate correlation between pollution and, general symptoms, quality life public transport drivers. Material methods Bus varying bus brands (F, O P)...

To determine the efficacy of montelukast in comparison with cabergoline prevention ovarian hyperstimulation syndrome (OHSS) rats.An experimental OHSS model was formed 35 female Wistar rats. Rats (22 days old) were randomized into 5 groups, each containing 7 animals. The control group received no therapy; mild administered pregnant mare serum gonadotropin (PMSG) 10 IU for 4 days, hCG on 5th day; severe PMSG 30 day group: mg/kg/day and cabergollne 100 microg/kg/day via oral gavage 6 (days...

Objective: Diabetes mellitus (DM) is a group of metabolic diseases with high blood glucose, which cause the damage and dysfunction some organ systems. Although various oral drugs are used to treat DM, they do not prevent development of&nbsp;DM related such as nephropathy retinopathy glucose dependent vascular diseases. Thus novel strategies for prevention treatment DM urgently needed. This research aimed reveal effects Thymus Vulgaris Lamiaceae (TVL) Thymbra Spicata (TSL) on damaging DM....

To evaluate the potential effect of bisphosphonates on bone mineral density (BMD) in patients who are treated with anti-androgen drugs and radiotherapy for metastatic prostate cancer.The data 31 cancer were during a 1-year period retrospectively reviewed. Patients divided 2 groups, which 17 group 1 zoledronic acid (4 mg/month, intravenous) 14 did not receive acid. BMD was measured before treatment at end 1st year by dual energy X-ray absorptiometry. Statistical analyses performed T test.Mean...

Aim: Diabetes mellitus (DM) is a metabolic disease due to increased blood glucose, with multiple organ involvement. Although various oral drugs are used treat DM, they do not prevent the development of DM related diseases such as cognitive disorder, neuropathy and vascular diseases. Thus novel strategies for prevention treatment urgently needed. This research aimed reveal effects Thymus Vulgaris Lamiaceae (TVL) Thymbra Spicata (TSL) on damaging DM. Materials Methods: Therefore, prepared TVL...

To evaluate the results of various types radiofrequency ablation (RFA) treatment renal tumors in patients with excessive anesthetic and surgical risk.Data for RFA performed high risk were retrospectively evaluated. Other applications no and/or excluded. was by ultrasound or CT guided percutaneous (USG/CT-PRFA) retroperitoneally transperitoneally laparoscopic (R/T-LRFA) techniques under general local anethesia. Follow-up data enhanced MRI after 1, 3 6 months analysed twelve applications.The...

Objectives: Regional studies of diabetes mellitus (DM) are important to determine effective environmental factors in the development DM and defining strategy against these factors. This study aims define frequency prevalence province Van city, distribution according age groups, socio-economical, geographical metabolic over development. Material methods: included 191 male 209 female totals 400 person aged year 16 years or over. Blood-Glucose levels persons were measured with Accu-check...

Aim: Diabetes mellitus (DM) is a metabolic disease due to increased blood glucose, with multiple organ involvement. Although various oral drugs are used treat DM, they do not prevent the development of DM related diseases such as cognitive disorder, neuropathy and vascular diseases. Thus novel strategies for prevention treatment urgently needed. This research aimed reveal effects Thymus Vulgaris Lamiaceae (TVL) Thymbra Spicata (TSL) on damaging DM. Materials Methods: Therefore, prepared TVL...

Amaç: Diabetes mellitus kan glukoz düzeyinin artmasına bağlı olarak ortaya çıkan metabolik bir hastalıktır.Bu hastalığa yanında serum parametrelerinde de değişimler gözlenebilmektedir.Bu hastalığın tedavisinde bilinen ilaçların dışında geleneksel bitkisel tedaviler kullanılmaktadır