Osman H. Yilmaz
A5100714760- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Viral-associated cancers and disorders
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Advanced biosensing and bioanalysis techniques
- Studies on Chitinases and Chitosanases
- Animal Virus Infections Studies
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Extracellular vesicles in disease
- T-cell and Retrovirus Studies
- Chromosomal and Genetic Variations
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Medical Imaging and Pathology Studies
- Galectins and Cancer Biology
- Ovarian function and disorders
- Circular RNAs in diseases
Beth Israel Deaconess Medical Center
2023-2025
Harvard University
2023-2025
Boston University
2024
Hadassah Medical Center
2023
University of Pittsburgh Medical Center
2023
Massachusetts General Hospital
2023
Brigham and Women's Hospital
2023
Massachusetts Institute of Technology
2023
Orient-Institut Istanbul
2016
Bezmiâlem Vakıf Üniversitesi
2015-2016
Abstract Improved biomarkers are needed for early cancer detection, risk stratification, treatment selection, and monitoring response. Although proteins can be useful blood-based biomarkers, many have limited sensitivity or specificity these applications. Long INterspersed Element-1 (LINE-1) open reading frame 1 protein (ORF1p) is a transposable element overexpressed in carcinomas high-risk precursors during carcinogenesis with negligible expression normal tissues, suggesting ORF1p could...
Aims WNT signalling pathway dysregulation is often a critical early component in colorectal neoplasia, particularly the chromosomal instability pathway. Using two reporters, LGR5 and AXIN2 , we sought to assess whether these polyps demonstrate predictable expression patterns if show diagnostic value. Methods We evaluated 23 adenomas (TA), sessile serrated lesions (SSLs), 14 SSL with dysplasia 38 traditional (TSA). Chromogenic situ hybridisation stains (ISH) for were performed. Reactivity was...
The cholangioblastic variant of intrahepatic cholangiocarcinoma is a distinctive neoplasm that typically affects young women without underlying liver disease. Morphologically, it demonstrates solid, trabecular, and tubulocystic architecture, biphasic small cell-large cell cytology, immunoreactivity for inhibin, neuroendocrine markers, biliary but not hepatocellular markers. In 2021, our group identified characteristic NIPBL::NACC1 gene fusion in cholangiocarcinoma, since then ~20 genetically...
We sought to assess the expression of human leukocyte antigen (HLA) proteins and β2-microglobulin (B2M) in tumor cells relationship with immune microenvironment outcome colorectal cancer (CRC).
Leukotrienes, one of the mediators inflammation in asthma, have a strong bronchoconstrictive effect. L-carnitine has been reported to influence respiratory functions. It also that inhibits leukotriene synthesis. To evaluate effects on oxygen saturation, urine E4 levels and lung histopathology murine model high IgE responder BALB/c mice (n = 24) were systemically sensitized ovalbumin chronically challenged with low particle mass concentrations aerosolized ovalbumin, then they divided into 3...
Distinguishing colon carcinoma that is surrounded by well-circumscribed lymphoid tissue from adenomas involving lymphoglandular complexes can be difficult. We assessed a multi-institutional international cohort of 20 colorectal carcinomas with associated prominent infiltrates, which we referred to as complex-like (LGCC). collected clinical and endoscopic features, including lesion size, appearance, location, procedure, follow-up, AJCC stage, mismatch repair status. recorded the presence...
To determine the efficacy of montelukast in comparison with cabergoline prevention ovarian hyperstimulation syndrome (OHSS) rats.An experimental OHSS model was formed 35 female Wistar rats. Rats (22 days old) were randomized into 5 groups, each containing 7 animals. The control group received no therapy; mild administered pregnant mare serum gonadotropin (PMSG) 10 IU for 4 days, hCG on 5th day; severe PMSG 30 day group: mg/kg/day and cabergollne 100 microg/kg/day via oral gavage 6 (days...
Mycobacterial spindle cell pseudotumors (MSPs) are a rare and diagnostically challenging manifestation of non-tuberculous mycobacterial (NTM) infections. Proper recognition these is important because they treatable benign. In this study, we evaluated the morphologic patterns MSPs to improve their pathologic identification. Clinical features 14 were analyzed. Histologic factors included architectural growth pattern spindled or epithelioid macrophages, granulomas location within lesion,...
<p>Calibration curves for “3rd Generation” Simoa assays.</p>
<p>Additional second-generation ORF1p Simoa assay measurements in healthy and cancer patients.</p>
<p>Assay validation for second-generation ORF1p Simoa assays.</p>
<p>Kaplan-Meier Survival Analysis by ORF1p.</p>
<p>Assay validation for second-generation ORF1p Simoa assays.</p>
<p>Screening of multimeric nanobodies for ORF1p detection with Simoa.</p>
<p>Circulating ORF1p levels in patients with IPMN</p>
<p>Circulating ORF1p levels in lung cancer patient cohort</p>
<p>Screening of newly developed monoclonal antibody candidates.</p>
<p>Additional second-generation ORF1p Simoa assay measurements in healthy and cancer patients.</p>
<p>Second round of screening newly developed monoclonal antibody and dimeric nanobody reagent pairs in patient plasma.</p>
<div>Abstract<p>Improved biomarkers are needed for early cancer detection, risk stratification, treatment selection, and monitoring response. Although proteins can be useful blood-based biomarkers, many have limited sensitivity or specificity these applications. Long INterspersed Element-1 (LINE-1) open reading frame 1 protein (ORF1p) is a transposable element overexpressed in carcinomas high-risk precursors during carcinogenesis with negligible expression normal tissues,...
<p>(obtained from Drapkin Lab at the University of Pennsylvania).Circulating CA125 and HE4 levels, as measured by Simoa, in ovarian cancer patient cohort.</p>