A5001102076- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Diet and metabolism studies
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Neuroblastoma Research and Treatments
- Pancreatitis Pathology and Treatment
- Gastrointestinal Tumor Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Microtubule and mitosis dynamics
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Genetic factors in colorectal cancer
- Congenital gastrointestinal and neural anomalies
- Epigenetics and DNA Methylation
- Peroxisome Proliferator-Activated Receptors
- Cholesterol and Lipid Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Pediatric Hepatobiliary Diseases and Treatments
- Potassium and Related Disorders
- Drug Transport and Resistance Mechanisms
- Cancer, Lipids, and Metabolism
- Intraperitoneal and Appendiceal Malignancies
University of California, Davis
2016-2025
UC Davis Comprehensive Cancer Center
2015-2025
University of California Davis Medical Center
2016-2024
United States University
2024
Harvard University
2023
UC Davis Health System
2019
Johns Hopkins University
2011-2016
Johns Hopkins Medicine
2012-2014
Cancer Research Center
2012
Stanford University
2010-2011
The nuclear receptors LXRα and LXRβ have been implicated in the control of lipogenesis cholesterol homeostasis. Ligand activation these vivoinduces expression LXR target gene SREBP-1c increases plasma triglyceride levels. Expression fatty acid synthase (FAS), a central enzyme de novo an established SREBP-1 pathway, is also induced by ligands. effects ligands on FAS proposed to be entirely secondary induction SREBP-1c. We demonstrate here that LXRs regulate through direct interaction with...
Defining the molecular genetic alterations underlying pancreatic cancer may provide unique therapeutic insight for this deadly disease. Toward goal, we report here an integrative DNA microarray and sequencing-based analysis of genomes. Notable among newly identified, genomic deletions, mutations, rearrangements recurrently targeted genes encoding components SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeling complex, including all three putative binding subunits (ARID1A, ARID1B,...
Idelalisib is a highly specific small-molecule phosphoinositide-3-kinase δ inhibitor that was recently approved by the Food and Drug Administration for treatment of chronic lymphocytic leukemia/small lymphoma follicular lymphoma. The known side effects idelalisib include severe diarrhea colitis. Here we report histologic findings in idelalisib-associated enterocolitis 11 patients with leukemia or receiving over 5-year period (2011 to 2015) at our institution. All were underwent colonoscopy...
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The recognition of mitogen-activated protein kinases (MAPKs) by their upstream activators, MAPK/ERK (MEKs), is crucial for the effective and accurate transmission many signals. We demonstrated previously that yeast MAPKs Kss1 Fus3 bind with high affinity to N terminus MEK Ste7, proposed a conserved motif in MAPK-docking site, mediates this interaction. Here we show corresponding sequences human MEK1 MEK2 are necessary sufficient direct binding ERK1 ERK2. Mutations MEK1, MEK2, or Ste7 altered...
Consumption of high fat diets (HFD) and the associated metabolic endotoxemia can initiate liver inflammation lipid deposition that with time progress to non-alcoholic fatty disease (NAFLD). We previously observed 14 weeks supplementation anthocyanidins cyanidin delphinidin mitigated HFD-induced insulin resistance, steatosis, oxidative stress. This work investigated if a 4-week mice cyanidin- delphinidin-rich extract (CDRE) could mitigate or reverse HFD (60% calories from lard fat)-induced...
We have identified 8 cases of gastritis characterized by the presence purple to black granular deposits in superficial mucosa associated with marked reactive epithelial changes. In each case, patient had taken OsmoPrep, a tablet form sodium phosphate used for bowel preparation just before upper endoscopy and undergone concurrent colonoscopy. Endoscopic findings ranged from normal gastric severe inflammation, congestion, friability. No other gastrointestinal sites were noted contain or show...
The Ki-67 index is an established prognostic factor in gastrointestinal neuroendocrine tumors (GI-NETs) and defines tumor grade. It currently estimated by microscopically examining tissue single-immunostained (SS) for counting the number of Ki-67-positive Ki-67-negative cells within a subjectively picked hot-spot. Intraobserver variability this procedure as well difficulty distinguishing from non-tumor can lead to inaccurate indices possibly incorrect grades. We introduce two computational...
Increased adiposity is a significant risk factor for pancreatic cancer development. Multiple preclinical studies have documented that high-fat, high calorie diets, rich in omega-6 fatty acids (FA) accelerate However, the effect of low sucrose diet (HFD), on carcinogenesis remains unclear. We evaluated impact HFD early-stage clinically relevant Kras
We discovered a nuclear receptor element in the FAS promoter consisting of an inverted repeat spaced by one nucleotide (IR-1) and located 21 bases downstream direct sequenced 4 nucleotides (DR-4) oxysterol liver X response element. An IR-1 is present promoters several genes bile acid lipid homeostasis binds farnesoid receptor/retinoid (FXR/RXR) heterodimers to mediate acid-dependent transcription. show that FXR/RXRalpha specifically activated approximately 10-fold addition synthetic FXR...
Liver X receptor (LXR) activates fatty acid synthase (FAS) gene expression through binding to a DR-4 element in the promoter. We show that distinct nuclear half-site 21 bases downstream of is also critical for response FAS LXR but not involved DNA. This specifically binds liver homologue-1 (LRH-1) vitro and vivo, we LRH-1 required maximal responsiveness endogenous as well from promoter reporter constructs. demonstrate stimulation blocked by addition small heterodimer partner (SHP) mRNA...
This study aimed to investigate radiomic features extracted from magnetic resonance imaging (MRI) scans performed before and after neoadjuvant chemoradiotherapy (nCRT) in predicting response of locally advanced rectal cancer (LARC).Thirty-nine patients who underwent nCRT for LARC were included, with 294 MRI that was (pre-CRT) 6 8 weeks completing (post-CRT). Based on tumor regression grade (TRG), 26 classified as having a histopathologic good (GR; TRG 0-1) 13 non-GR (TRG 2-3). Tumor...
Pancreatic ductal adenocarcinoma (PDAC) continues to be a major health problem. A ketogenic diet (KD), characterized by very low carbohydrate and high fat composition, has gained attention for its anti-tumor potential. We evaluated the effect mechanisms of feeding strict KD alone or in combination with gemcitabine autochthonous LSL-KrasG12D/+; LSL-Trp53 R172H/+; Pdx1-Cre (KPC) mouse model. For this purpose, both male female pancreatic tumor-bearing KPC mice were allocated control (CD; %kcal:...
Gastric cancer is the fifth leading cause of cancer-related deaths worldwide. Over 95% gastric cancers are adenocarcinomas, which typically classified based on anatomic location and histologic type. generally carries a poor prognosis because it often diagnosed at an advanced stage. Systemic therapy can provide palliation, improve survival, enhance quality life in patients with locally or metastatic disease. The implementation biomarker testing has had significant impact clinical practice...
In the clinical practice of pathology, trichrome stains are commonly used to highlight collagen and help evaluate fibrosis. Such do delineate deposits but not molecularly specific can suffer from staining inconsistencies. Moreover, performing histochemical stain evaluation requires preparation additional sections beyond original hematoxylin- eosin-stained slides, as well steps, which together add cost, time, workflow complications. We have developed a new microscopy approach, termed DUET...
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor response to systemic therapies, including immunotherapy. Given the immunotherapeutic potential of natural killer (NK) cells, we evaluated intratumoral NK cell infiltrates along cytotoxic T cells in PDAC determine their association patient outcomes.