A5040215407- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Pancreatitis Pathology and Treatment
- Tea Polyphenols and Effects
- Diet, Metabolism, and Disease
- Gut microbiota and health
- Cancer Mechanisms and Therapy
- Cancer-related Molecular Pathways
- Nutrition, Genetics, and Disease
University of California, Davis
2020-2024
Increased adiposity is a significant risk factor for pancreatic cancer development. Multiple preclinical studies have documented that high-fat, high calorie diets, rich in omega-6 fatty acids (FA) accelerate However, the effect of low sucrose diet (HFD), on carcinogenesis remains unclear. We evaluated impact HFD early-stage clinically relevant Kras
Although body fatness is a recognized risk factor for pancreatic ductal adenocarcinoma (PDAC), the underlying mechanisms of how fat composition affects carcinogenesis are poorly understood. High-fat diets (HFDs) can disrupt intestinal barrier function, potentially accelerating carcinogenesis. Omega-3 (ω-3) polyunsaturated fatty acids (FAs) have anti-inflammatory properties and help preserve integrity.
Pancreatic cancer is one of the deadliest cancers, with a 5 year survival rate around 10% globally. Although obesity modifiable risk factor for this cancer, role high-fat diet (HFD) intake in pancreatic carcinogenesis, effects dietary modification from an HFD to low-fat diet, and underlying molecular mechanisms action are poorly defined. To contribute understanding these relationships, we assessed global gene expression modulations using LSL-KrasG12D/+p48Cre/+ (KC) mouse model. Five-week-old...
Abstract Increased adiposity represents a modifiable risk factor of pancreatic cancer. Multiple preclinical studies have shown that high-fat and high-sugar diets on the acceleration carcinogenesis, in context obesity. However, impact resembling omega-6 to omega-3 fatty acid (FA) ratio Western-style diet, remains unclear. Furthermore, role mesenteric adipose tissue (MAT) carcinogenesis is poorly characterized. Thus, we aimed determine diet with 9 parts FA each FA, early stages genetically...
Abstract Background: Pancreatic cancer is the 3rd leading cause of cancer-related deaths in USA. Given limited clinical benefit current treatments, pancreatic prevention appears as a key approach to lowering mortality and suffering caused by this disease. A modifiable risk factor for diet. Previous studies have indicated that high fat diets, but also sugar accelerate carcinogenesis. Although link between increased body fatness apparent, specific role played different dietary fats remains...