A5054682745- RNA and protein synthesis mechanisms
- Various Chemistry Research Topics
- Science Education and Pedagogy
- Folate and B Vitamins Research
- Innovative Teaching Methods
- Biochemical and Molecular Research
- Porphyrin Metabolism and Disorders
- RNA modifications and cancer
- Educational Strategies and Epistemologies
- Bacterial Genetics and Biotechnology
- Genomics and Phylogenetic Studies
- Mitochondrial Function and Pathology
- RNA Research and Splicing
- Chemical Safety and Risk Management
- Vitamin D Research Studies
- Advanced Breast Cancer Therapies
- Career Development and Diversity
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced Text Analysis Techniques
- Engineering Education and Pedagogy
- Cancer-related Molecular Pathways
- Innovative Teaching and Learning Methods
- Bacteriophages and microbial interactions
Wayne State University
2024
University of Michigan
2020-2024
Ann Arbor Center for Independent Living
2020
University of Michigan–Flint
2016-2018
Learning to reason through organic reaction mechanisms is challenging for students because of the volume reactions covered in introductory chemistry and complexity conceptual knowledge reasoning skills required develop meaningful understanding. However, understanding valuable they are useful predicting explaining outcomes. To identify features find pertinent when mechanisms, we have collected students’ written descriptions an acid-catalysed amide hydrolysis reaction. Students’ writing was...
Thermodynamics and kinetics are key topics in the chemistry curriculum that pose challenges to students across a range of educational levels. These struggles arise from complexity mixed representations inherent topics. Additionally, while thermodynamics related, struggle make conceptually correct connections, sometimes seeing them as two separate with no relation other times conflating their meanings explanatory powers. Herein we captured student conceptions about through Writing-to-Learn...
Students enroll in biochemistry courses for many reasons, whether it be to build a strong foundation content health science-related careers or better understand the world around them. Learning is enriched when students can identify relevance of content, such as through connecting course authentic applications. One way that make these connections by practicing science communication, an increasingly important skill master. Drawing upon advantages writing, we designed assignment tasked with...
Mitochondrial diseases linked to mutations in mitochondrial (mt) tRNA sequences are common. However, the contributions of these development is mostly unknown. Mutations may affect interactions with (mt)tRNA maturation enzymes or protein synthesis machinery leading dysfunction. In human mitochondria, most cases first step processing removal 5' leader precursor tRNAs (pre-tRNA) catalyzed by three-component enzyme, mtRNase P. Additionally, one component P, RNase P 1 (MRPP1), catalyzes...
Abstract Protein‐only RNase P (PRORP) is an essential enzyme responsible for the 5′ maturation of precursor tRNAs (pre‐tRNAs). PRORPs are classified into three categories with unique molecular architectures, although all classes share a mechanism and have similar active sites. Single subunit PRORPs, like those found in plants, multiple isoforms different localizations, substrate specificities, temperature sensitivities. Most recently, Arabidopsis thaliana PRORP2 was shown to interact TRM1A...
<h2>ABSTRACT</h2> tRNAs are typically transcribed with extended 5' and 3' ends that must be removed before they attain their active form. One of the first steps tRNA processing in nearly every organism is removal leader sequence by ribonuclease P (RNase P). Here, we investigate a newly discovered class RNase enzymes, Homologs <i>Aquifex</i> (HARPs). In contrast to other Ps, HARPs consist only metallonuclease domain lack substrate recognition domains essential classes enzymes. We determined...
Triple-negative breast cancer (TNBC) is a highly aggressive that disproportionately affects women with darker skin and often treated paclitaxel (PTX). Here, the effect of vitamin D on p53-positive DU4475 cells its ability to decrease IC50 PTX in these were investigated.The growth inhibitory effects plus overall TNBC cell viability was assessed using CellTiter-Glo®.Vitamin increased proliferation at low concentrations lowered PTX. However, it did not change MDA-MB-231 which remained largely...
With the highly interdisciplinary nature of biochemistry, and diverse range students taking introductory biochemistry courses, it can be difficult to incorporate authentic applications course content that appeal broadly students. However, is important engage students' learning at affective level. One mode achieve this goal by incorporating assignments support in identifying relevance skills they are learning. In study we incorporated an assignment placed role science communicators, where...
Abstract Cobalamin (vitamin B 12 ) and its derivatives play an essential role in biological methylation, with cobalamin-dependent methionine synthase (MS) serving as a canonical example. MS catalyzes multiple methyl transfers within single, dynamic multi-domain architecture that has proven challenging to study, hampering efforts elucidate catalytic mechanism(s). Utilizing thermostable homolog non-native cobalamin cofactors, we have captured crystal structures of transient conformational...
<title>Abstract</title> Cobalamin (vitamin B<sub>12</sub>) and its derivatives play an essential role in biological methylation, with cobalamin-dependent methionine synthase (MS) serving as a canonical example. MS catalyzes multiple methyl transfers within single, dynamic multi-domain architecture that has proven challenging to study, hampering efforts elucidate catalytic mechanism(s). Utilizing thermostable homolog non-native cobalamin cofactors, we have captured crystal structures of...