A5051331502- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Neurogenesis and neuroplasticity mechanisms
- Receptor Mechanisms and Signaling
- Lipid Membrane Structure and Behavior
- Neural dynamics and brain function
- CRISPR and Genetic Engineering
- Protein Kinase Regulation and GTPase Signaling
- Metabolism, Diabetes, and Cancer
- Retinal Development and Disorders
- Immune Response and Inflammation
- Hemispheric Asymmetry in Neuroscience
- Advanced Neuroimaging Techniques and Applications
- Neonatal and fetal brain pathology
- Animal Behavior and Reproduction
- Congenital heart defects research
- Pluripotent Stem Cells Research
- Primate Behavior and Ecology
- Nuclear Receptors and Signaling
University of Illinois Urbana-Champaign
2021-2023
Washington University in St. Louis
2014-2018
Hiram College
2010
The relative contributions of glycolysis and oxidative phosphorylation to neuronal presynaptic energy demands are unclear. In rat hippocampal neurons, ATP production by either or alone sustained basal evoked synaptic transmission for up 20 min. However, combined inhibition both sources abolished transmission. Neither action potential propagation failure nor depressed Ca 2+ influx explained loss Rather, synthesis caused massive spontaneous vesicle exocytosis, followed arrested endocytosis,...
Abstract Astrocytes play active roles at synapses and can monitor, respond, adapt to local synaptic activity. While there is abundant evidence that astrocytes modulate excitatory transmission in the hippocampus, for astrocytic modulation of hippocampal inhibition remains more limited. Furthermore, better investigate modulating transmission, tools selectively activate native G protein signaling pathways with both spatial temporal precision are needed. Here, we utilized AAV8‐GFAP‐Optoα1AR‐eYFP...
Neuron–astrocyte interactions are critical for proper CNS development and function. Astrocytes secrete factors that pivotal synaptic function, neuronal metabolism, survival. Our understanding of this relationship, however, remains incomplete due to technical hurdles have prevented the removal astrocytes from circuits without changing other important conditions. Here we overcame obstacle by growing solitary rat hippocampal neurons on microcultures were comprised either an astrocyte bed...
Abstract The diet of capuchin monkeys consists largely fruits, but these commonly prey upon insects and other invertebrates as well vertebrates such lizards, birds, fish. Capturing small fast‐moving requires the ability to process complex visuospatial information motion detection, shape, pursuit. Here we report results an experimental investigation into whether capuchins display sex differences in capture efficiency, are associated with morphology regions corpus callosum (CC) involved...
Neurons require a nearly constant supply of ATP. Glucose is the predominant source brain ATP, but direct effects prolonged glucose deprivation on neuronal viability and function remain unclear. In sparse rat hippocampal microcultures, neurons were surprisingly resilient to 16 h removal in absence secondary excitotoxicity. Neuronal survival synaptic transmission unaffected by exogenous glucose. Inhibition lactate transport decreased microculture during concurrent deprivation, suggesting that...
Abstract Astrocytes play active roles at synapses and can monitor, respond, adapt to local synaptic activity. To investigate this relationship, more tools that selectively activate native G protein signaling pathways in astrocytes with both spatial temporal precision are needed. Here, we tested AAV8-GFAP-Optoα1AR-eYFP (Optoα1AR), a viral vector enable activation of q via light-sensitive α1-adrenergic receptors. determine if stimulating astrocytic Optoα1AR modulates hippocampal transmission,...