A5025833037- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Neurological disorders and treatments
- Antioxidant Activity and Oxidative Stress
- Cholinesterase and Neurodegenerative Diseases
- Asthma and respiratory diseases
- NF-κB Signaling Pathways
- Neurological diseases and metabolism
- Genomics, phytochemicals, and oxidative stress
- Retinal Development and Disorders
- Aluminum toxicity and tolerance in plants and animals
- Genetic Neurodegenerative Diseases
- Cell Adhesion Molecules Research
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Ubiquitin and proteasome pathways
Emory University
2013-2015
Hampton University
2013
University of Pennsylvania
2007-2010
In response to oxidative stress, the nuclear factor E2-related 2 (Nrf2) transcription translocates from cytoplasm into nucleus and transactivates expression of genes with antioxidant activity. Despite this cellular mechanism, damage is abundant in Alzheimer Parkinson disease (AD PD). To investigate mechanisms by which Nrf2 activity may be aberrant or insufficient neurodegenerative conditions, we assessed localization affected brain regions AD, Lewy body variant AD (LBVAD), PD. By...
Abstract A variety of mutations in the gene encoding DJ‐1 protein cause autosomal recessive early‐onset parkinsonism. Recently, a novel pathogenic homozygous missense mutation resulting L10P amino acid substitution was reported. In separate study, deletion residue P158 also reported to be causative disease. The specific effects and P158DEL on function have not been studied. Here, proteins were assessed for stability, dimerization, solubility, subcellular localization, protective comparison...
Parkinson's disease (PD) is the most common neurodegenerative movement disorder. A pathological hallmark of PD presence intraneuronal inclusions composed fibrillized α-synuclein (α-syn) in affected brain regions. Mutations gene, PARK7, which encodes DJ-1, can cause autosomal recessive early-onset PD. Although DJ-1 has been shown to be involved diverse biological processes, several vitro studies suggest that it inhibit formation and protect against effects α-syn aggregation. We previously...
Various mutations in the PARK2 gene which encodes protein, parkin, are causal of a disease entity-termed autosomal recessive juvenile parkinsonism. Parkin can function as an E3 ubiquitin-protein ligase, mediating ubiquitination specific targeted proteins and resulting proteasomal degradation. is thought to lead parkinsonism consequence loss its function. In this study, immunoblot analyses brain extracts from Balb/c, C57BL/6, C3H, 129S mouse strains demonstrated significant variations...