A5040426315- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Genomics and Chromatin Dynamics
- PI3K/AKT/mTOR signaling in cancer
- Bioinformatics and Genomic Networks
- Cancer therapeutics and mechanisms
- RNA and protein synthesis mechanisms
- Gastric Cancer Management and Outcomes
- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Chemokine receptors and signaling
- Protein Degradation and Inhibitors
- Acute Lymphoblastic Leukemia research
- Pancreatic and Hepatic Oncology Research
- Acute Myeloid Leukemia Research
- Lung Cancer Research Studies
- Liver physiology and pathology
- Epigenetics and DNA Methylation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Research and Splicing
- Radiomics and Machine Learning in Medical Imaging
European Molecular Biology Laboratory
2021-2023
Institute of Oncology NN Petrov
2018-2022
European Molecular Biology Laboratory
2022
Heidelberg University
2022
Saint Petersburg State Pediatric Medical University
2018-2021
Research Medical Center
2020
Enhancers play a vital role in gene regulation and are critical mediating the impact of noncoding genetic variants associated with complex traits. Enhancer activity is cell-type-specific process regulated by transcription factors (TFs), epigenetic mechanisms variants. Despite strong mechanistic link between TFs enhancers, we currently lack framework for jointly analysing them regulatory networks (GRN). Equally important, an unbiased way assessing biological significance inferred GRNs since...
Abstract Among the biggest challenges in post-GWAS (genome-wide association studies) era is interpretation of disease-associated genetic variants non-coding genomic regions. Enhancers have emerged as key players mediating effect on complex traits and diseases. Their activity regulated by a combination transcription factors (TFs), epigenetic changes variants. Several approaches exist to link enhancers their target genes, others that infer TF-gene connections. However, we currently lack...
Abstract Background Despite the progress in development of next‐generation sequencing (NGS), diagnostic PCR assays remain to be utilized clinical routine due their simplicity and low cost. Tests for 5′‐/3′‐end mRNA unbalanced expression can used variant‐independent detection translocations, however, many technical aspects this methodology require additional investigations. Methods Known ALK / ROS1 fusions were analyzed 2009 EGFR mutation‐negative non‐small cell lung cancer (NSCLC) samples...
In contrast to other countries with predominantly white populations, Russian smoking-related lung cancers (LC) are mainly squamous cell carcinomas and approximately half adenocarcinomas (AdCa) not related tobacco consumption.Given that smoking significantly influences the probability of presence actionable mutations in LC, one would expect AdCa patients differ from populations distribution EGFR, ALK, KRAS BRAF mutations.Herein, 2,336 consecutive cases, including 1,203 known status, were...
Despite the unprecedented success in using immune checkpoint inhibitors treatment of lung cancer, melanoma, hypermutable tumors various localization, etc., a significant proportion patients receiving these drugs do not respond to treatment. Predictive markers routinely used selection for immunotherapy, particular, level expression PD -L1 and presence microsatellite instability, have certain limitations. Over past decade, many other biomarkers designed predict response immunotherapy been...
Abstract Somatic mutations in hematopoietic stem/progenitor cells (HSPCs) can lead to clonal hematopoiesis of indeterminate potential (CHIP), potentially progressing myelodysplastic syndromes (MDS). Here, we investigated how CHIP and MDS remodel the human bone marrow (BM) niche relative healthy elderly donors, using single cell anatomical analyses a large BM cohort. We found distinct inflammatory remodeling MDS. Furthermore, stromal compartment progressively lost its HSPC-supportive...
The mutation-based analysis of circulating tumor DNA (ctDNA) is a promising diagnostic tool for clinical oncology. However, it has low success rate because many cancer patients do not have detectable ctDNA in the bloodstream.To evaluate whether preoperative irradiation results transient increase plasma concentration due to induction apoptosis radiation-exposed cells.This study focused on with locally advanced rectal cancer, part their standard treatment plan. Nine subjects, whose tumors...
DNA from formalin-fixed paraffin-embedded (FFPE) tissues, which are frequently utilized in cancer research, is significantly affected by chemical degradation. It was suggested that approaches based on duplex sequencing can improve the accuracy of mutation detection FFPE-derived DNA. However, original method cannot be for analysis as FFPE contains an excessive number damaged bases, and these lesions converted to false double-strand nucleotide substitutions during polymerase-driven end repair...