A5066083180- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- SARS-CoV-2 detection and testing
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Bioinformatics and Genomic Networks
- Trypanosoma species research and implications
- Single-cell and spatial transcriptomics
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- COVID-19 epidemiological studies
- Research on Leishmaniasis Studies
- Animal Virus Infections Studies
European Molecular Biology Laboratory
2021-2024
Lebanese American University
2020-2022
Enhancers play a vital role in gene regulation and are critical mediating the impact of noncoding genetic variants associated with complex traits. Enhancer activity is cell-type-specific process regulated by transcription factors (TFs), epigenetic mechanisms variants. Despite strong mechanistic link between TFs enhancers, we currently lack framework for jointly analysing them regulatory networks (GRN). Equally important, an unbiased way assessing biological significance inferred GRNs since...
The Integrator complex attenuates gene expression via the premature termination of RNA polymerase II (RNAP2) at promoter-proximal pausing sites. It is required for stimulus response, cell differentiation, and neurodevelopment, but how gene-specific adaptive regulation by achieved remains unclear. Here, we identify two sites on human subunits 13/14 that serve as binding hubs sequence-specific transcription factors (TFs) other effector complexes. When attached to paused RNAP2, these are...
ABSTRACT The Integrator complex (INT) regulates gene expression via premature transcription termination of RNA polymerase II (RNAP2) at promoter-proximal pausing sites. This attenuation is required for cellular response to external stimuli, cell differentiation and neurodevelopment. How gene-specific regulation achieved by INT in an inducible manner remains unclear. Here, we identify two sites on subunits 13/14 that serve as direct binding hubs diverse sets sequence-specific factors (TFs)...
Leishmania tropica is one of the main causative agents cutaneous leishmaniasis (CL). Population structures L. appear to be genetically highly diverse. However, relationship between strains genomic diversity, protein coding gene evolution and biogeography are still poorly understood. In this study, we sequenced genomes three new clinical isolates, two derived from a recent outbreak CL in camps hosting Syrian refugees Lebanon historical isolate Azerbaijan further refine comparative genome...
Abstract Among the biggest challenges in post-GWAS (genome-wide association studies) era is interpretation of disease-associated genetic variants non-coding genomic regions. Enhancers have emerged as key players mediating effect on complex traits and diseases. Their activity regulated by a combination transcription factors (TFs), epigenetic changes variants. Several approaches exist to link enhancers their target genes, others that infer TF-gene connections. However, we currently lack...
The aim of this study was to characterize the transmission chains and clusters COVID-19 infection in Tunisia.
The world has been dealing with the SARS-COV-2 pandemic since December 2019 and a lot of effort focused on tracking spread virus by gathering information regarding testing statistics generating viral genomic sequences. Unfortunately, there is neither single comprehensive resource global historical data nor centralized database summary identified variants. We merged different pre-aggregated complemented them our manually extracted ones, which consist 6852 test from 76 countries/states...
Abstract The world has been dealing with the COVID-19 pandemic since December 2019 and a lot of effort focused on tracking spread virus by gathering information regarding testing statistics generating viral genomic sequences. Unfortunately, there is neither single comprehensive resource global historical data nor centralized database summary identified variants.We merged different pre-aggregated complemented them our manually extracted ones, which consist 6852 test from 76 countries/states...