A5018235434- Insect Pest Control Strategies
- Research on Leishmaniasis Studies
- Parasitic Infections and Diagnostics
- Trypanosoma species research and implications
- Coccidia and coccidiosis research
- Amoebic Infections and Treatments
- Phytochemical compounds biological activities
- Parasite Biology and Host Interactions
- Reproductive tract infections research
- Insect and Pesticide Research
- Essential Oils and Antimicrobial Activity
- Helminth infection and control
- Traditional and Medicinal Uses of Annonaceae
- Bioactive Natural Diterpenoids Research
- Microbial infections and disease research
- Natural product bioactivities and synthesis
- Parasites and Host Interactions
- Pesticide Residue Analysis and Safety
- Plant-based Medicinal Research
- Vector-Borne Animal Diseases
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Herbal Medicine Research Studies
- Protist diversity and phylogeny
- Bioactive Compounds and Antitumor Agents
- Plant Parasitism and Resistance
Universidad Autónoma de Madrid
2013-2023
National Institute of Engineering, Technology and Innovation
2006
Instituto de Productos Naturales y Agrobiología
2005
Hospital Universitario De Cabueñes
2004
Universidad de Las Palmas de Gran Canaria
2003
Universidad Complutense de Madrid
1992-1997
Consejo Superior de Investigaciones Científicas
1997
Rega Institute for Medical Research
1996
Artemisia absinthium is an aromatic and medicinal plant of ethnopharmacological interest it has been widely studied. The use A. based on the collection wild populations can result in variable compositions extracts essential oils (EOs). aim this paper identification active components vapour pressure (VP) EO from a selected cultivated Spanish population (T2-11) against two parasitic protozoa with different metabolic pathways: Trypanosoma cruzi Trichomonas vaginalis. VP showed activity both...
Five annonaceous acetogenins, rolliniastatin-1 (1), rolliniastatin-2 (2), laherradurin (3), squamocin (4), annonacin (5), and rotenone as a reference, differing in their NADH oxidase inhibition activity, have been evaluated for antifeedant, insecticidal, trypanocidal cytotoxic effects on insect, mammalian tumor cells. All the test compounds were toxic to Leptinotarsa decemlineata, demonstrated selective cytotoxicity insect Sf9 cells panel of cell lines with multidrug-resistant SW480...
Ten indole alkaloids were isolated from Geissospermum reticulatum, seven (1–7) the leaves and three (8–10) bark. Seven aspidospermatan-type (1–3, 5–9), including four (5–8) with a 1-oxa-3-cyclopentene group in their molecule, which we named geissospermidine subtype. Compounds 1–3, 5–8, 10 had not been reported previously as natural products, while 4 9 known O-demethylaspidospermine flavopereirine. Their structures determined by spectroscopic techniques 1D 2D NMR experiments (COSY, NOESY,...
Here, we describe the synthesis, bioactivity screening, and structure−activity relationships of various synthetic triterpenoids prepared from cork processing byproducts friedelin (1) 3-hydroxyfriedel-3-en-2-one (2) via oxidative procedures. The synthesis compounds 2α-trimethylsiloxyfriedelan-3-one (17), friedelin-2,3-lactone (18), friedelin-3-oxime (19), friedelin-3,4-lactam (20) is also described. We have studied insecticidal phytotoxic potential these compounds, their selective cytotoxic...
Biological parameters of five Trypanosoma cruzi strains from different sources were determined in order to know the laboratory behaviour natural populations. The evaluated growth kinetics epimastigotes, differentiation into metacyclic forms, infectivity mammalian cells grown vitro and parasite susceptibility nifurtimox, benznidazole gentian violet. Differences transformation metacyclic, percentage infected as well number amastigotes per cell observed among strains. Regarding pharmacological...
Given the importance of genus Artemisia as a source valuable natural products, rare plant pedemontana subspecies assoana, endemic to Iberian Peninsula, has been experimentally cultivated in greenhouse and aeroponically, produce biomass for essential oil (EO) extraction. The chemical composition EOs was analyzed, their protection (insects: Spodoptera littoralis, Rhopalosiphum padi, Myzus persicae; plants: Lactuca sativa Lolium perenne; fungi: Aspergillus niger; nematode: Meloidogyne javanica)...
The in vitro activity on Leishmania infantum promastigotes and Trypanosoma cruzi epimastigotes of 25 semisynthetic terpenoid derivatives has been evaluated. These compounds were obtained through chemical modifications the major components Euphorbia resinifera (α-euphol α-euphorbol) officinarum (obtusifoliol 31-norlanosterol). Leishmaniasis Chagas´ disease are worldwide health problems. drugs choice for their treatment still problematic both cases, therefore there is an urgent need to...
Cantharidin (CTD) is a toxic monoterpene produced by blister beetles (Fam. Meloidae) as chemical defense against predators. Although CTD highly poisonous to many predator species, some have evolved the ability feed on Meloidae, or otherwise beneficially use beetles. Great Bustards, Otis tarda, eat CTD-containing Berberomeloe majalis beetles, and it has been hypothesized that beetle consumption these birds reduces parasite load (a case of self-medication). We examined this hypothesis testing...
Trichomonas gallinae is a flagellated protozoan that parasitizes the upper digestive tract of various bird species and causes avian trichomonosis. The emergence resistant strains to standard treatment, based on nitroimidazoles, increases need find alternative therapies. In this study, 36 essential oils (EOs) from Lamiaceae Asteraceae plant families were tested against T. trophozoites using 3-(4,5-dimethylthiazol-2-yl-)-2,5-dipheniltetrazolium bromide (MTT) reduction assay. Among them, EOs...
Five oxindole alkaloids, three plumerane-type subtype haplophitine, and one aspidospermatane-type alkaloid, tubotaiwine, were isolated from the medicinal plants Aspidosperma rigidum A. schultesii. One compound was identified as transoid conformer of 18-oxo-O-methylaspidoalbine which not previously described. The antiparasitic activity all compounds against Trypanosoma cruzi Leishmania infantum their non-specific cytotoxicity mammalian cells also determined.
Twenty-seven diterpenes, including abietanes, labdanes, abeoabietanes, halimanes, and pimaranes, have been evaluated against epimastigote intracellular amastigote forms of Trypanosoma cruzi also LC5 NCTC cell lines. Royleanones (3, 4, 5) a further abietane (12), obtained by purification Plectranthus spp. extracts, were the most active compounds on epimastigotes, showing IC50 values similar (1.73 µg/mL, 12) or even lower (0.39, 0.99, 1.20 3, 5 respectively) than positive control nifurtimox...