A5020583135- Viral gastroenteritis research and epidemiology
- Clostridium difficile and Clostridium perfringens research
- Antibiotic Resistance in Bacteria
- Prion Diseases and Protein Misfolding
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Trace Elements in Health
- Salmonella and Campylobacter epidemiology
- Escherichia coli research studies
- SARS-CoV-2 detection and testing
- Infection Control in Healthcare
- SARS-CoV-2 and COVID-19 Research
- Gut microbiota and health
- Pharmaceutical and Antibiotic Environmental Impacts
- Amino Acid Enzymes and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Prostate Cancer Diagnosis and Treatment
- Bacterial biofilms and quorum sensing
- Microbial infections and disease research
- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Bacteriophages and microbial interactions
- Infectious Encephalopathies and Encephalitis
Universidad de Zaragoza
2016-2024
Centro de Investigación y Tecnología Agroalimentaria de Aragón
2016-2023
Instituto de Investigación Sanitaria Aragón
2022
Metronidazole was until recently used as a first-line treatment for potentially life-threatening Clostridioides difficile (CD) infection. Although cases of metronidazole resistance have been documented, no clear mechanism or role plasmids in antimicrobial has described CD. Here, we report genome sequences seven susceptible and sixteen resistant CD isolates from human animal sources, including patient with recurrent infection by PCR ribotype (RT) 020 strain, which developed to over the course...
To determine the presence of Clostridium difficile on fattening pig farms in north-eastern Spain.Twenty-seven were sampled. Pools faecal samples (n = 210), intestinal content from common farm pest species 95) and environment-related 93) collected. Isolates tested for toxin genes C. difficile, typed by PCR-ribotyping toxinotyping. The minimal inhibitory concentrations six antimicrobial agents determined using Etest. Thirty-four isolates obtained 12 farms, 30 (88·2%) had genes. Seven ribotypes...
Farmed minks have been reported to be highly susceptible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and may represent a risk humans. In this study, we describe the first outbreak of SARS-CoV-2 occurred on mink farm in Spain, between June July 2020, involving 92,700 animals. The started shortly after some workers became seropositive for SARS-CoV-2. Minks showed no clinical signs compatible with infection throughout outbreak. Samples from 98 were collected histopathological,...
Escherichia coli ( E. ) is a pathogen frequently isolated in cases of urinary tract infections (UTIs) both humans and dogs evidence exists that are reservoirs for human infections. In addition, associated to increasing antimicrobial resistance rates. This study focuses on the analysis presence selected virulence genes isolates from Spanish dog population suffering UTI. collection showed an extremely high level phenotypic 1st–3rd generation cephalosporins, followed by penicillins,...
The carriage of two important pathogens pigs, that is enterotoxigenic Escherichia coli (ETEC) and Clostridioides difficile, was investigated in 104 cloacal samples from wild griffon vultures (Gyps fulvus) fed on pig carcasses at supplementary feeding stations (SFS), along with their level antimicrobial resistance (AMR). E. isolated 90 (86.5%) samples, but no ETEC detected, likely because fimbriae confer the species specificity pathogen. Resistance to least one agent detected 89.9% isolates,...
The emergence of bovine spongiform encephalopathy (BSE) prions from atypical scrapie has been recently observed upon experimental transmission to rodent and swine models. This study aimed assess whether the inoculation could induce BSE-like disease in cattle. Four calves were intracerebrally challenged with scrapie. Animals euthanized without clinical signs prion tested negative for PrPSc accumulation by immunohistochemistry western blotting. However, an seeding activity was detected during...
Abstract The aim of this study was to estimate the prevalence antimicrobial resistance (AMR) in Escherichia coli from a dog population Spain and assess specific virulence factors. Susceptibility 22 antimicrobials tested along with production extended-spectrum β-lactamases (ESBLs) AmpC faecal isolates 100 dogs. Virulence-related genes associated attaching effacing E. ( eae , Stx1 Stx2 ) extraintestinal pathogenic – ExPEC papC hlyA cnf1 were detected by PCR. At least one kind AMR observed 73%...
Nowadays, there is a great concern about the prevalence of multidrug resistant Enterococcus spp. and Enterobacteriaceae in food-producing animals. The aim this work was to evaluate effect oxytetracycline or enrofloxacin treatment on vancomycin-resistant enterococci (VRE), extended spectrum β-lactamase (ESBL) carbapenemase-producing pigs. A total 26 piglets were received distributed three groups. Group 1 treated with (N = 12), group 2 10) 3 did not receive any (control group) 4). higher...
Clostridium difficile (C. difficile) is a major nosocomial infectious agent in hospitals. Previous studies have addressed the high proportion of infection episodes that are overlooked health care facilities.the main aim this study was to characterize C. clinical cases occurred secondary hospital during five-month period.for purpose, total 137 stool samples from same number patients with diarrhea were analyzed for presence by culture techniques. An enzyme immunoassay (EIA) test detection and...
Current diagnostic methods for prion diseases only work in late stages of the disease when neurodegeneration is irreversible. Therefore, biomarkers that can detect before onset clinical symptoms are necessary. High-throughput discovery proteomics great interest search such molecules. Here we used mass spectrometry to analyse cerebrospinal fluid proteome an animal disease: preclinical and sheep affected with natural scrapie, healthy sheep. Interestingly, found 46 proteins stage were...
Abstract Background Metronidazole is used to treat mild- moderate Clostridioides difficile infections (CDI). No clear mechanism for metronidazole resistance has been described C. . A patient treated in the Leiden University Medical Center suffered from recurrent CDI caused by a PCR ribotype (RT) 020 strain which developed (MIC = 8 mg/L). Resistance also seen animal isolates, predominantly of RT010. Methods Six susceptible and 12 resistant isolates human origin, including were analyzed whole...
Scrapie, a naturally occurring prion disease affecting goats and sheep, comprises classical atypical forms, with scrapie being the archetype of transmissible spongiform encephalopathies. This review explores challenges diagnosis utility various biomarkers their potential implications for human diseases. Understanding these in context may enable earlier humans, which is crucial effective intervention. Research on bridges gap between veterinary medicine, offering hope early detection improved...
Enterococcus hirae is a zoonotic species that causes opportunistic infections in both humans and animals can be transmitted by contact with or through contaminated food. The aim of this study was to investigate the importance E. broilers endocarditis, as well antimicrobial resistance patterns genetic relatedness isolates. A total 477 three- five-week-old were studied during five fattening periods on farm mortality due endocarditis. Endocarditis observed 27 chickens (5.66%), samples taken for...