David A. Wilkie

ORCID: 0000-0002-4237-0371
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About
Contact & Profiles
Research Areas
  • Intraocular Surgery and Lenses
  • Glaucoma and retinal disorders
  • Ocular Surface and Contact Lens
  • Ocular Infections and Treatments
  • Corneal Surgery and Treatments
  • Corneal surgery and disorders
  • Veterinary Oncology Research
  • Traffic Prediction and Management Techniques
  • Traffic control and management
  • Veterinary Equine Medical Research
  • Ocular Oncology and Treatments
  • Connexins and lens biology
  • Retinal and Macular Surgery
  • Heat Transfer and Optimization
  • Ocular Disorders and Treatments
  • Transportation Planning and Optimization
  • Evacuation and Crowd Dynamics
  • Retinal Diseases and Treatments
  • Heat Transfer Mechanisms
  • Human Mobility and Location-Based Analysis
  • Traumatic Ocular and Foreign Body Injuries
  • Infectious Diseases and Mycology
  • Meteorological Phenomena and Simulations
  • Cancer and Skin Lesions
  • Retinal Development and Disorders

Allergy Therapeutics (United Kingdom)
2024

The Ohio State University
2011-2020

Sellafield (United Kingdom)
1967-2019

United Kingdom Atomic Energy Authority
1968-2019

Ricardo AEA (United Kingdom)
1967-2019

University of North Carolina at Chapel Hill
2009-2017

Heriot-Watt University
2016

University of North Carolina Wilmington
2015

WiLAN (Canada)
2014

In-Q-Tel
2014

The advances in mobile computing and social networking services enable people to probe the dynamics of a city. In this paper, we address problem detecting describing traffic anomalies using crowd sensing with two forms data, human mobility media. Traffic are caused by accidents, control, protests, sport events, celebrations, disasters other events. Unlike existing traffic-anomaly-detection methods, identify according drivers' routing behavior on an urban road network. Here, detected anomaly...

10.1145/2525314.2525343 article EN 2013-11-05

Ultraviolet radiation (UVR) is a risk factor for the development of ocular disease in humans, including acute photokeratitis, chronic corneal spheroidal degeneration, and cataract formation. This report describes lesions seen 21 mice chronically exposed to UVR as part skin carcinogenicity study. All globes were affected varying degrees. The primary lesion, not previously reported UVR-exposed mice, was marked loss keratocytes relative age-matched controls. Secondary included stromal thinning,...

10.1080/01926230701584197 article EN Toxicologic Pathology 2007-10-01

We address the problem of real-time navigation in dynamic environments for car-like robots. present an approach to identify controls that will lead a collision with moving obstacle at some point future. Our generalizes concept velocity obstacles, which have been used among and takes into account constraints robot. use this formulation find allow free environments. Finally, we demonstrate performance our algorithm on simulated robot obstacles.

10.1109/iros.2009.5354175 article EN 2011 IEEE/RSJ International Conference on Intelligent Robots and Systems 2009-10-01

We introduce a novel, online method to predict pedestrian trajectories using agent-based velocity-space reasoning for improved human–robot interaction and collision-free navigation. Our formulation uses velocity obstacles model the trajectory of each moving in robot’s environment improves motion by adaptively learning relevant parameters based on sensor data. The resulting agent is computed statistical inferencing techniques, including combination ensemble Kalman filters maximum-likelihood...

10.1177/0278364914555543 article EN The International Journal of Robotics Research 2014-12-09

To determine the long-term efficacy, complications, and duration of effect a cyclosporine (CsA) suprachoroidal implant (CSI) in horses with equine recurrent uveitis (ERU).Horses ERU were treated 6-mm diameter, 25 mg, reservoir matrix CsA deep sclera adjacent to space. Horses follow-up >1 year examined for frequency episodes, vision at last recheck.Data from 151 eyes 133 USA Europe that had devices implanted reviewed. Follow-up time ranged 13 85 months after surgery, mean median 28.9 26.3...

10.1111/j.1463-5224.2010.00807.x article EN Veterinary Ophthalmology 2010-09-02

Urban transportation is increasingly studied due to its complexity and economic importance. It also a major component of urban energy use pollution. The importance this topic will only increase as urbanization continues around the world. A less researched aspect refueling behavior drivers. In paper, we propose step toward real-time sensing citywide petrol consumption. We reported trajectories from fleet GPS-equipped taxicabs detect gas station visits, measure time spent, estimate overall...

10.1145/2493432.2493448 article EN 2013-09-08

This paper presents LQG-Obstacles, a new concept that combines linear-quadratic feedback control of mobile robots with guaranteed avoidance collisions obstacles. Our approach generalizes the Velocity Obstacles [3] to any robotic system linear Gaussian dynamics model. We integrate Kalman filter for state estimation and an LQR controller into closed-loop model which higher-level objective is "control input". then define LQG-Obstacle as set objectives result in collision high probability....

10.1109/icra.2012.6224648 article EN 2012-05-01

Abstract We present a novel method for the synthesis and animation of realistic traffic flows on large‐scale road networks. Our technique is based continuum model flow we extend to correctly handle lane changes merges, as well behaviors due in speed limit. demonstrate how our can be applied many vehicles network at interactive rates show that simulate believable publicly‐available, real‐world data. furthermore scalability this many‐core systems.

10.1111/j.1467-8659.2009.01613.x article EN Computer Graphics Forum 2010-05-01

We present a novel, real-time algorithm for modeling large-scale, realistic traffic using hybrid model of both continuum and agent-based methods simulation. simulate individual vehicles in regions interest state-of-the-art models driver behavior, use faster flow the remainder road network. Our key contributions are efficient techniques dynamic coupling discrete vehicle simulation with aggregated behavior demonstrate flexibility scalability our interactive visual technique on extensive...

10.1145/2024156.2024169 article EN 2011-12-12

SUMMARY Intraocular pressure ( iop ) was measured, using applanation tonometry, in both eyes of 20 horses after topical application 0.5% proparacaine to the cornea. Ultrasonic pachymetry used measure central, mid-peripheral, and peripheral corneal thickness ct all 4 quadrants 25 horses. All measurements were repeated auriculopalpebral nerve block, sedation by iv administration xylazine, or combination block sedation. Mean anesthesia cornea 20.6 ± 4.7 mm Hg for left eye 20.35 3.7 right eye....

10.2460/ajvr.1995.56.02.155 article EN American Journal of Veterinary Research 1995-02-01

To determine the feasibility, safety, and effectiveness of an episcleral or deep scleral lamellar sustained release cyclosporine (CsA) device in a naturally occurring animal model uveitis.A two-compartment perfusion chamber was used to assess vitro human equine permeability fluorescein, dexamethasone-fluorescein, CsA. A biodegradable, matrix-reservoir CsA implant designed, rates were determined vitro. Tissue levels measured eyes with implant. Horses recurrent uveitis (ERU) received implants...

10.1167/iovs.05-1540 article EN Investigative Ophthalmology & Visual Science 2006-05-24

SUMMARY Effects of topical administration a single dose timolol maleate on intraocular pressure ( iop ) and pupil diameter were evaluated in normotensive eyes 11 clinically normal dogs over 12 hours (7:00 am to 7:00 pm ). Mean (± sem was 15.5 1.1) mm Hg diurnal fluctuation observed, with the highest seen morning. 8.5 0.3) mm. Topical treatment 0.5% resulted reduction treated nontreated eyes. eye 2.5 Hg, 16.1%, maximal 3.7 Hg. 1.4 9.0%. The had reduced at 30 minutes after treatment, which...

10.2460/ajvr.1991.52.03.432 article EN American Journal of Veterinary Research 1991-03-01

There exists a vast amount of geographic information system (GIS) data that model road networks around the world as polylines with attributes. In this form, are insufficient for applications such simulation and 3D visualization-tools which will grow in power demand sensor become more pervasive governments try to optimize their existing physical infrastructure. paper, we propose an efficient method enhancing map from GIS database create geometrically topologically consistent be used real-time...

10.1109/tvcg.2011.116 article EN IEEE Transactions on Visualization and Computer Graphics 2011-06-28

We present a novel, real-time algorithm for modeling large-scale, realistic traffic using hybrid model of both continuum and agent-based methods simulation. simulate individual vehicles in regions interest state-of-the-art models driver behavior, use faster flow the remainder road network. Our key contributions are efficient techniques dynamic coupling discrete vehicle simulation with aggregated behavior demonstrate flexibility scalability our interactive visual technique on extensive...

10.1145/2070781.2024169 article EN ACM Transactions on Graphics 2011-11-30

Urban transportation is an important factor in energy consumption and pollution, of increasing concern due to its complexity economic significance. Its importance will only increase as urbanization continues around the world. In this article, we explore drivers’ refueling behavior urban areas. Compared questionnaire-based methods past, propose a complete data-driven system that pushes towards real-time sensing individual citywide petrol consumption. Our provides following: detection events...

10.1145/2644828 article EN ACM Transactions on Intelligent Systems and Technology 2015-04-21

'Virtualized traffic' reconstructs and displays continuous traffic flows from discrete spatio-temporal sensor data or procedurally generated control input to enhance a sense of immersion in dynamic virtual environment. In this paper, we introduce fast technique reconstruct in-road measurements for interactive 3D visual applications. Our algorithm estimates the full state flow sparse (or procedural input) using statistical inference method continuum model. This estimated then drives an...

10.1145/2461912.2462021 article EN ACM Transactions on Graphics 2013-07-16

10.2307/2347954 article EN Journal of the Royal Statistical Society Series C (Applied Statistics) 1983-01-01

To describe the clinical presentation and surgical outcome of diabetic canine patients with cataracts preoperative spontaneous lens capsule rupture.A total 20 dogs 40 eyes were included in retrospective evaluation. The patients' ages ranged from 5 to 14 years (mean 8.5 years).All had diabetes mellitus, duration since diagnosis ranging 30 240 days 123 days). Cataracts bilateral noted have been present for 14-112 39 Of affected cataracts, a rupture prior surgery. capsular was diagnosed on...

10.1111/j.1463-5224.2006.00490.x article EN Veterinary Ophthalmology 2006-08-25

Traffic congestion is a perpetual challenge in metropolitan areas around the world. The ability to understand traffic dynamics thus critical effective control and management. However, estimation of conditions over large-scale road network has proven be challenging task for two reasons: first, are intrinsically stochastic; second, availability quality data vary great extent. Traditional monitoring systems that exist mostly on major roads highways insufficient recover an entire network. Recent...

10.1109/mits.2017.2709804 article EN IEEE Intelligent Transportation Systems Magazine 2017-01-01

Records of 147 dogs with cataracts and that had an ultrasonographic examination their eyes were reviewed. Ultrasonography was performed, using a real-time mechanical sector scanner (7.5 or 10.0 MHz transducer), after topical anesthesia the cornea. Vitreous degeneration diagnosed in 23% examined. Retinal detachment detected 11% all eyes, but 4% immature cataracts, 6.5% mature 19% hypermature cataracts. In 66% cataract only abnormality found. retinal most often observed cataract, uncommon...

10.2460/javma.1993.203.06.0838 article EN Journal of the American Veterinary Medical Association 1993-09-15

Abstract Objective —To determine effects of topical antimicrobial and antimicrobial-corticosteroid preparations on the ocular flora horses. Animals —40 Procedure —One eye was treated 3 times daily for 2 weeks with one following ointments: 1) neomycinbacitracin- polymyxin B, 2) 0.6% prednisolone-0.3% gentamicin, 3) neomycin-polymyxin B-0.05% dexamethasone, or 4) (artificial tears) control. Contralateral eyes control served as untreated eyes. Corneal conjunctival specimens bacterial fungal...

10.2460/ajvr.2005.66.800 article EN American Journal of Veterinary Research 2005-05-01
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