A5039836204- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Cardiac Ischemia and Reperfusion
- Vestibular and auditory disorders
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Acute Kidney Injury Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Anesthesia and Sedative Agents
- Airway Management and Intubation Techniques
- Nitric Oxide and Endothelin Effects
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Connexins and lens biology
- Cardiovascular Function and Risk Factors
- Respiratory Support and Mechanisms
- Heart Failure Treatment and Management
- Cellular transport and secretion
- Hip and Femur Fractures
- Anesthesia and Neurotoxicity Research
- Circadian rhythm and melatonin
- Cardiac Valve Diseases and Treatments
- Intensive Care Unit Cognitive Disorders
- Thermal Regulation in Medicine
- Bat Biology and Ecology Studies
University Medical Center Groningen
2010-2024
University of Groningen
2008-2022
Dialyse Centrum Groningen
2009
Univé (Netherlands)
2000
Erasmus University Rotterdam
1988-1990
Leiden University
1983-1985
Postoperative renal function deterioration is a serious complication after cardiac surgery with cardiopulmonary bypass and associated increased in-hospital mortality. However, the long-term prognosis of patients postoperative not fully determined yet. Therefore, both mortality survival were studied in deterioration. Included 843 who underwent 1991. (increase serum creatinine first week at least 25%) occurred 145 (17.2%) patients. In these patients, was 14.5%, versus 1.1% without (P < 0.001)....
Background Cardiovascular instability after intravenous induction of anesthesia may be explained partly by direct negative inotropic effects. The influence etomidate, ketamine, midazolam, propofol, and thiopental on the contractility isolated human atrial tissue was determined. Effective concentrations were compared with those reported clinically. Methods Atrial obtained from 16 patients undergoing coronary bypass surgery. Each fragment divided into three strips, one anesthetic tested per...
Hibernation is an energy-conserving behavior consisting of periods inhibited metabolism (‘torpor’) with lowered body temperature. Torpor bouts are interspersed by arousal periods, in which increases and temperature returns to euthermia. In deep torpor, the typically decreases 2–10 °C, major physiological immunological changes occur. One these alterations constitutes almost complete depletion circulating lymphocytes that reversed rapidly upon arousal. Here we show torpor induces storage...
Abstract Critically ill patients constitute a highly heterogeneous population, with seemingly distinct having similar outcomes, and the same admission diagnosis opposite clinical trajectories. We aimed to develop machine learning methodology that identifies provides better characterization of patient clusters at high risk mortality kidney injury. analysed prospectively collected data including co-morbidities, examination, laboratory parameters from minimally-selected population 743 admitted...
A variety of perioperative risk factors are associated with postoperative mortality risk. However, the relative contribution routinely collected intraoperative clinical parameters to short-term and long-term remains understudied.To examine performance multiple machine learning models data from different periods predict 30-day, 1-year, 5-year investigate that contribute these predictions.In this prognostic study using prospectively data, prediction were developed for after cardiac surgery....
Abstract The vestibulocerebellar projection in the rabbit has been investigated by anterograde axonal transport of tritiated leucine, wheat germ‐agglutinated horseradish peroxidase, and Phaseolus vulgaris leucoagglutinin. Mossy fiber terminals originating from all vestibular nuclei, with exception lateral nucleus Deiters, were found bilaterally lobules X, IX, VIII caudal vermis, without a clear difference laterality. Most mossy vermis originated superior medial nuclei. Application different...
Abstract With the use of retrograde transport horseradish peroxidase we confirmed observation Yamamoto and Shimoyama ([1977] Neurosci Lett. 5 :279‐283) that Purkinje cells rabbit flocculus projecting to medial vestibular nucleus are located in two discrete zones, FZ II IV , alternate with other cell I III superior nucleus. The retrogradely labeled axons these collect four bundles occupy corresponding floccular white matter compartments, FC 1 –4 can be delineated acetylcholinesterase...
Perioperative acute myocardial infarction (AMI) is a serious complication of cardiac surgery, leading to increased morbidity and mortality (1). Currently, the diagnosis AMI based on changes in electrocardiogram release biochemical markers. However, are not sensitive specific, whereas creatine kinase MB (CKMB) specific (2). The new markers troponin I T discriminate between skeletal muscle damage (3)(4). Coronary artery bypass grafting (CABG) can be performed with or without (“off-pump”) use...
Although the centrifugal pump has been widely used as a nonpulsatile for cardiopulmonary bypass (CPB), little is known about its performance pulsatile CPB, especially on efficacy in producing hemodynamic energy and clinical effectiveness. We performed study to evaluate whether Rotaflow produces effective flow during CPB this setting clinically adult patients undergoing cardiac surgery. Thirty-two elective coronary artery grafting were randomly allocated perfusion group (n = 16) or 16). All...
Background: The inclusion of facial and bodily cues (clinical gestalt) in machine learning (ML) models improves the assessment patients' health status, as shown genetic syndromes acute coronary syndrome. It is unknown if clinical gestalt ML-based classification acutely ill patients. As previous research ML analysis medical images, simulated or augmented data may be used to assess usability gestalt. Objective: To whether a deep algorithm trained on dataset photographs reflecting patients can...