A5047638254- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Pneumonia and Respiratory Infections
- Tuberculosis Research and Epidemiology
- Antibiotic Use and Resistance
- Vibrio bacteria research studies
- DNA and Nucleic Acid Chemistry
- Phenothiazines and Benzothiazines Synthesis and Activities
- Collagen: Extraction and Characterization
- Pharmacogenetics and Drug Metabolism
- RNA Interference and Gene Delivery
- Mentoring and Academic Development
- Hemoglobinopathies and Related Disorders
- Pharmaceutical and Antibiotic Environmental Impacts
- HIV/AIDS drug development and treatment
- Eosinophilic Disorders and Syndromes
- Advanced biosensing and bioanalysis techniques
- Malaria Research and Control
- Health and Medical Research Impacts
- Leprosy Research and Treatment
- Cancer therapeutics and mechanisms
- Evolution and Genetic Dynamics
- Proteoglycans and glycosaminoglycans research
- Protein Kinase Regulation and GTPase Signaling
- Cancer Treatment and Pharmacology
University of North Carolina at Chapel Hill
2017-2024
Ionis Pharmaceuticals (United States)
2022-2023
University at Buffalo, State University of New York
2016-2018
ABSTRACT Safe and effective therapies are urgently needed to treat polymyxin-resistant KPC-producing Klebsiella pneumoniae infections suppress the emergence of resistance. We investigated pharmacodynamics polymyxin B, rifampin, meropenem alone as B-based double triple combinations against K. isolates. The rates extents killing with B (1 128 mg/liter), rifampin (2 16 (10 120 mg/liter) were evaluated B-susceptible (PB s ) B-resistant r clinical isolates using 48-h static time-kill studies....
Transthyretin-mediated amyloidosis is a progressive and fatal disease caused by the build-up of misfolded transthyretin (TTR) protein. Eplontersen triantennary N-acetyl galactosamine (GalNAc3)-conjugated antisense oligonucleotide targeting TTR messenger ribonucleic acid (mRNA) to inhibit production both variant wild-type TTR. We aimed develop population pharmacokinetic/pharmacodynamic (PK/PD) model for eplontersen evaluate impact covariates on exposure response.Plasma serum concentration...
ZTI-01 (fosfomycin for injection) is a broad-spectrum antibiotic with novel mechanism of action and currently under development in the United States treatment complicated urinary tract infections. Globally, fosfomycin polymyxin B are increasingly being used to treat multidrug-resistant Gram-negative The objectives were evaluate pharmacodynamic activity alone combination against KPC-producing Klebsiella pneumoniae assess rate extent emergence resistance different regimens. Two clinical...
The multidrug resistance profiles of Klebsiella pneumoniae carbapenemase (KPC) producers have led to increased clinical polymyxin use. Combination therapy with polymyxins may improve treatment outcomes, but it is uncertain which combinations are most effective. Clinical successes intravenous minocycline-based combination treatments been reported for infections caused by carbapenemase-producing bacteria. objective this study was evaluate the in vitro activity B and minocycline against six...
The emergence of highly resistant bacteria is a serious threat to global public health. host immune response vital for clearing from the infected host; however, current drug development paradigm does not take host-pathogen interactions into consideration. Here, we used systems-based approach develop quantitative, mechanism-based disease progression model describe bacterial dynamics, response, and lung injury in an immunocompetent rat pneumonia model. Previously, Long-Evans rats were with...
Mounting antimicrobial resistance to carbapenemase‐producing Klebsiella pneumoniae (CPKP) highlights the need optimize currently available treatment options. The objective of this study was explore alternative dosing strategies that limit emergence preserve utility last‐line antibiotics by: (i) evaluating pharmacodynamic (PD) killing activity simulated humanized exposures monotherapy and two‐drug three‐drug combinations against CPKP bacterial isolates with different mechanisms; (ii)...
Cartilage proteoglycan aggregates are separated from collagen and other non-proteoglycan protein by preparative rate zonal sedimentation under associative conditions. Dissociative produces sedimented of lower content with a corresponding increase in the amount less sedimentable protein-rich proteoglycan. An extensive number sequential sedimentations discloses that proceess disaggregation involves separation proteoglycans varying continuously composition no apparent discontinuities...