A5079715270- Rheumatoid Arthritis Research and Therapies
- Cell Adhesion Molecules Research
- Chronic Lymphocytic Leukemia Research
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- Lymphoma Diagnosis and Treatment
- Orthopedic Infections and Treatments
- Systemic Sclerosis and Related Diseases
- Infective Endocarditis Diagnosis and Management
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune and Inflammatory Disorders Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Biosimilars and Bioanalytical Methods
- Inflammatory Myopathies and Dermatomyositis
- Hematological disorders and diagnostics
- Otitis Media and Relapsing Polychondritis
- Inflammasome and immune disorders
- Viral Infections and Immunology Research
- Protease and Inhibitor Mechanisms
- Osteoarthritis Treatment and Mechanisms
- Cancer Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Mycobacterium research and diagnosis
- Antimicrobial agents and applications
Turku University Hospital
2015-2024
University of Turku
2014-2024
Varsinais-Suomen Sairaanhoitopiiri
2021-2024
Center for Rheumatology
2020
Karolinska Institutet
2019
Pfizer (United States)
2015
AstraZeneca (United Kingdom)
2015
Helsinki University Hospital
1999
Herttoniemi Hospital
1999
University of Helsinki
1999
Because of the role tumor necrosis factor (TNF) in host defense, it was hypothesized that its inhibition might lead to an increased risk malignancies and infections. The objective our study assess incidence serious infections leading hospitalization among patients with rheumatoid arthritis (RA) receiving either TNF inhibitor or rituximab (RTX) therapy.The population identified from National Register for Biologic Treatment Finland hospital records Central Hospital conventional...
Objectives Diagnosing polymyalgia rheumatica (PMR) can be difficult as many conditions present with similar symptoms and findings. This study aimed to analyse how often the diagnosis of PMR changes during follow-up in a university hospital setting determine most common clinical initially misdiagnosed PMR.Method All patients new primary on at least one visit years 2016–2019 were identified from discharge register Turku University Hospital, Finland. A was confirmed if patient met five...
Efficacy of TNF inhibitors in the treatment RA assessed randomized controlled trials (RCTs) may not be fully comparable to routine care owing stringent inclusion criteria. The objective this study was observe effectiveness real-world patients and assess patients' potential eligibility for RCTs.RA starting a TNF-inhibitor between 2004 2014 were identified from National Register Biologic Treatment Finland, which is longitudinal observational cohort study. Effectiveness measured using ACR EULAR...
Patients receiving chemotherapy are prone to neutropoenic infections, presenting with non-specific symptoms such as a high fever and elevated inflammatory parameters. Large-vessel vasculitis (LVV) may have similar clinical presentation should be included in differential diagnostics. A few published case reports adverse event suggest causal association between LVV the use of granulocyte colony-stimulating factor (G-CSF) chemotherapy. Our objective was evaluate relationship LVV, G-CSF
Abstract Objective . To examine mutational activation of ras proto‐oncogenes in synovial tissue from patients with rheumatoid arthritis (RA) compared specimens osteoarthritis (OA) or other arthropathies. Synovial samples cadavers, without any signs joint disease, were used as control material. Methods Using a combination polymerase chain reaction (PCR) and automated sequencing the amplified PCR product, regions around codons 12, 13, 61 H‐, K‐, N‐ analyzed. Confirmation mutations was based on...
Objective: A systematic review found that an average of 27% rheumatoid arthritis (RA) patients using tumour necrosis factor (TNF) inhibitors discontinue their treatment within 1 year. The aim this study was to assess drug survival on TNF among with RA.Methods: Patients were identified from the National Register for Biologic Treatment in Finland (ROB-FIN), which is a longitudinal cohort established monitor effectiveness and safety biologic drugs rheumatic diseases. Inclusion limited...
In patients with axial spondyloarthritis (axSpA) initiating their first tumor necrosis factor alpha-inhibitor (TNFi), we aimed to identify common baseline predictors of Ankylosing Spondylitis Disease Activity Score (ASDAS-CRP) inactive disease (primary objective) and clinically important improvement (CII) at 6 months, drug retention 12-months across 15 European registries.Baseline demographic clinical characteristics were collected. Outcomes investigated per registry in pooled data using...
Purpose . This study evaluated the potential of 68 Ga-citrate positron emission tomography/computed tomography (PET/CT) for detection infectious foci in patients with Staphylococcus aureus bacteraemia by comparing it 2-[ 18 F]fluoro-2-deoxy-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>D</mml:mi></mml:mrow></mml:math>-glucose ( F-FDG) PET/CT. Methods. Four admitted to hospital due S. underwent both F-FDG and whole-body PET/CT scans detect foci. Results....
Frequent monitoring of patients with early rheumatoid arthritis (RA) is required for achieving good outcomes. This study was undertaken to investigate the influence text message (SMS)-enhanced on RA outcomes.We randomized 166 early, disease-modifying antirheumatic drug-naive receive SMS-enhanced follow-up or routine care. All attended visits at 0, 3, and 6 months, a visit 12 months. Treatment physicians' discretion. The intervention included 13 SMSs during weeks 0-24 questions concerning...
Abstract We report the extent, specific sites and structural requirements of joint inflammation related citrullination in extracellular proteins. A total 40 synovial fluid samples derived from chronically inflamed human joints were analysed by heparin-agarose fractionation LC-MS/MS. Citrullination 55 arginines proteins was detected. Importantly, 20% have a characterized function to hallmarks destructive inflammation. E.g. four arginine residues, shown here be citrullinated, are also affected...
Sialic acid–binding immunoglubulinlike lectin 9 (Siglec-9) is a ligand of vascular adhesion protein 1. A <sup>68</sup>Ga-labeled peptide Siglec-9, <sup>68</sup>Ga-DOTA-Siglec-9, holds promise as novel PET tracer for imaging inflammation. This first-in-humans study investigated the safety, tolerability, biodistribution, and radiation dosimetry this radiopharmaceutical. <b>Methods:</b> Six healthy men underwent dynamic whole-body PET/CT. Serial venous blood samples were drawn from 1 to 240 min...
The diagnosis of cardiac implantable electronic device (CIED) infection is challenging because its variable presentations. We studied the value 2-[18F]fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in detection CIED infection. Thirty patients with suspected underwent 18F-FDG-PET/CT. control group was ten asymptomatic who cancer-related 18F-FDG-PET/CT evaluated visually, semiquantitatively as maximum standardized uptake (SUVmax) and...
Mice heterozygous for the Del1 transgene locus with a short deletion mutation in type II collagen gene develop early-onset degenerative changes knee joints that progress to end-stage osteoarthritis by age of 12-15 months. This study focuses on expression and distribution syndecan-1, cell-surface heparan sulfate proteoglycan, during development osteoarthritic cartilage degeneration, better understand its role this disease.Northern analyses total RNA extracted from transgenic mice their...
To evaluate the performance of biological drugs in psoriatic arthritis (PsA) a routine care setting, using Finnish national register treatment (ROB-FIN).Patients with PsA who started therapy infliximab or etanercept between June 2000 and February 2006 (n = 127) were followed for up to 24 months. Response was evaluated American College Rheumatology response criteria including individual measures.Significantly diminished values swollen tender joints, patient's global pain assessments, doctor's...
To demonstrate the expression of laminins (Lns) and their integrin (Int) receptors in different synovial samples membrane-like interface tissues from well fixed aseptically loosened total hip replacement (THR), potential role Ln-Int interaction production collagenases cytokines.Immunohistochemical staining was done to detect distribution EHS Ln, Ln alpha2, alpha3, alpha5, beta1, beta2 chains Int alpha1, alpha6, beta4 subunits samples. Double immunofluorescence labelling used find...
We describe a case of postpericardiotomy syndrome imaged by positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) and computed (CT). A 53-year-old woman had surgical aortic valve replacement mechanical prosthesis due to severe regurgitation. Within 1 month surgery, she was diagnosed inflammatory pericarditis …
Objective: To assess what proportion of patients with disease-modifying anti-rheumatic drug (DMARD)-naïve early rheumatoid arthritis (ERA) reach 28-joint Disease Activity Score (DAS28) remission over 1 year, and variability across clinics in Finland.Method: Patients DMARD-naïve newly diagnosed inflammatory were recruited. The three variables (DAS28-3) was compared sites. Repeated measures analysed using a mixed models approach appropriate distribution link function.Results: In total, 611...
18 F-Fluorodeoxyglucose positron-emission tomography ( F-FDG-PET) with computed (CT) is effective for diagnosing large vessel vasculitis, but its usefulness in accurately suspected, unselected vasculitis remains unknown. We evaluated the feasibility of F-FDG-PET/CT real-life cohort patients suspicion vasculitis. The effect dose and timing glucocorticoid (GC) medication on imaging findings were special interest. 82 suspected by whole-body F-FDG-PET/CT. GC treatment as prednisolone equivalent...
Objective. Increased atherosclerosis in RA is not fully explained by the ordinary risk factors, but it may be related to vascular inflammation. The aim of this study was investigate degree carotid artery inflammation drug-naive patients with early before and after DMARD triple therapy. Methods. Fifteen non-diabetic recently diagnosed [age 51 (16) years, 6 males] were examined at 2 4 weeks initiation combination therapy MTX, SSZ, HCQ ⩽10 mg/day oral prednisolone. Eight healthy males aged 49...