The main objective of this research was to carry out an experimental study, triple-blind, on the possible immunophysiological effects a nutritional supplement (synbiotic, Gasteel Plus®, Heel España S.A.U.), containing mixture probiotic strains, such as Bifidobacterium lactis CBP-001010, Lactobacillus rhamnosus CNCM I-4036, and longum ES1, well prebiotic fructooligosaccharides, both professional athletes sedentary people. some inflammatory/immune (IL-1β, IL-10, immunoglobulin A) stress...

Fibromyalgia (FM) and chronic fatigue syndrome (CFS) are two medical conditions in which pain, fatigue, immune/inflammatory dysregulation, as well various mental health disorders predominate the diagnosis, without evidence of a clear consensus on treatment FM CFS. The main aim this research was to analyse possible effects synbiotic (Synbiotic, Gasteel Plus® (Heel España S.A.U.), through study pro-inflammatory/anti-inflammatory cytokines (IL-8/IL-10) neuroendocrine biomarkers (cortisol DHEA),...

Objectives: Balneotherapy with mud application (mud therapy) is a common hydrothermal intervention for the treatment and rehabilitation of elderly patients osteoarthritis, leading to anti-inflammatory effects. The main purpose this investigation was study role regulatory T cells in these second objective assess whether neutrophil-mediated innate response affected by effects.Methods: Thirty-six knee osteoarthritis underwent 10-day cycle balneotherapy at spa center. They received daily...

To analyse the relationship between health-related quality of life (HRQoL) and sociodemographic clinical factors in patients with diabetes mellitus, also comparing Spanish population-based reference values.Cross-sectional descriptive-analytical observational study through nonprobability sampling on diabetic from San Roque Primary Health Centre (Badajoz, Spain), using a questionnaire regarding care data, SF-36 Duke-UNC questionnaires, history data.Sixty (55% women) fundamentally type 2 mean...

Although osteoarthritis (OA) has predominantly been considered a noninflammatory degenerative arthropathy, there is growing evidence that various inflammatory and immunological processes might contribute to the onset, progression, burden of disease.The purpose present investigation was study systemic stress responses innate response mediated by neutrophils in OA patients.A group patients diagnosed with primary according American College Rheumatology criteria control age-matched healthy...

Although the predominant symptom in fibromyalgia (FM) is muscle pain, and fatigue chronic syndrome (CFS), differential diagnosis very difficult. This research investigates psychoneuroimmunoendocrine disorders of FM patients ascertains whether a previous CFS affected them. Through accelerometry objective parameters, physical activity/sedentarism levels relation to are studied, as well perceived stress, anxiety, pain correspond biomarkers, all these with respect reference group (RG) women...

Macrophages are crucial in the inflammation associated with obesity. Exercise is main non-pharmacological strategy against obesity, not only for improving metabolic impairment, but also because of its anti-inflammatory effects, particularly those mediated by β2 adrenergic receptors (β2-AR). Nevertheless, these effects could immunocompromise innate response pathogen challenge. Thus, objective this work was to evaluate effect and exercise condition, on regulation function macrophages. High fat...

Obesity has reached global epidemic proportions, and even though its effects are well-documented, studying the interactions among all influencing factors is crucial for a better understanding of physiopathology. In high-fat-diet-induced obesity animal model using C57BL/6J mice, behavioural responses were assessed through battery tests, while stress biomarkers systemic inflammatory cytokines measured an Enzyme-Linked ImmunoSorbent Assay Bio-Plex Multiplex System. The peritoneal macrophage...

Osteoarthritis (OA) is a common chronic condition that causes pain and disability, particularly in the elderly, resulting significant limitations on mobility overall quality of life. Balneotherapy using peloids (mud therapy) an effective, non-pharmacological treatment for OA improves symptoms function. This pilot study aimed to assess whether controlled-matured peloid, supplemented with rosmarinic acid (RosA), could enhance clinical outcomes, functional status, immune response patients. The...

Anomalous immune/inflammatory responses in obesity take place along with alterations the neuroendocrine and dysregulation immune/stress feedback mechanisms. Exercise is a potential anti-inflammatory strategy this context, but influence of exercise on β2 adrenergic regulation monocyte-mediated inflammatory response remains completely unknown. The first objective study was to analyze effect profile phenotype monocytes from obese lean animals, second aim determine whether could affect...

Analizar la relación entre calidad de vida relacionada con salud (CVRS) y variables sociodemográficas clínicas pacientes diagnosticados diabetes mellitus, comparando además los valores referencia para población española. Estudio descriptivo-analítico observacional trasversal por muestreo no probabilístico intencional en mellitus del Centro Salud San Roque (Badajoz, España), usando cuestionarios datos sociodemográficos cuidado diabetes, SF-36 Duke-UNC, historia clínica. Se estudiaron 60 (55%...

Fibromyalgia (FM) and Chronic Fatigue Syndrome (CFS) are two diseases that frequently codiagnosed present many similarities, such as poor tolerance to physical exercise. Although exercise is recommended in their daily routine improve quality of life, little known about how CFS codiagnosis affects that. Using scientifically validated questionnaires, we evaluated the psychological state life patients with FM (n = 70) habitual (HPE) reported by only (FM-only n 38) or (FM + CFS, 32) influences...

Obesity is a chronic low-grade inflammatory condition, and β2-adrenergic agonists as well exercise have been proposed anti-inflammatory strategies in obesity, so it critical to accurately determine the effects of stimulation, especially when combined with other non-pharmacological therapies. The aim this investigation was effect activation on profile phenotype macrophages, whether these could be affected by obesity condition. High-fat diet-induced obese lean C57BL/6J mice were allocated...