A5048275840- Galectins and Cancer Biology
- Peptidase Inhibition and Analysis
- Toxin Mechanisms and Immunotoxins
- Nitric Oxide and Endothelin Effects
- Signaling Pathways in Disease
- Antifungal resistance and susceptibility
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Fungal Infections and Studies
University of Gothenburg
2017-2023
Neutrophils have the ability to capture and kill microbes extracellularly through formation of neutrophil extracellular traps (NETs). These are DNA protein structures that neutrophils release believed function as a defense mechanism against microbes. The classic NET process, triggered by, e.g., bacteria, fungi, or by direct stimulation kinase C phorbol myristate acetate, is an active process takes several hours relies on production reactive oxygen species (ROS) further modified...
Abstract Galectin-3 is an endogenous β-galactoside-binding lectin comprising a carbohydrate recognition domain (CRD) linked to collagen-like N-domain. Both domains are required for galectin-3 induce cellular effects; C-terminal fragment of galectin-3, galectin-3C, containing the CRD but lacking N-domain, binds cell surface glycoconjugates does not effects since cross-linking promoted by N-domain thought be required. Instead, galectin-3C proposed antagonize competing binding sites. The aim...
ABSTRACT Staphylococcus aureus is a major cause of skin and soft tissue infection. The bacterium expresses four proteases that are emerging as virulence factors: aureolysin (Aur), V8 protease (SspA), staphopain A (ScpA), B (SspB). We hypothesized human galectin-3, β-galactoside-binding lectin involved in immune regulation antimicrobial defense, target for these proteolysis galectin-3 novel evasion mechanism. Indeed, supernatants from laboratory strains clinical isolates S. caused...
Abstract Among the responders to microbial invasion, neutrophils represent earliest and perhaps most important immune cells that contribute host defense with primary role kill invading microbes using a plethora of stored anti-microbial molecules. One such process is production reactive oxygen species (ROS) by neutrophil enzyme complex NADPH-oxidase, which can be assembled active either extracellularly or intracellularly in phagosomes (during phagocytosis) and/or granules (in absence...