A5055618035- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Additive Manufacturing and 3D Printing Technologies
- Muscle Physiology and Disorders
University of Virginia
2021
Charlottesville Medical Research
2021
Modern algorithms for biological segmentation can match inter-human agreement in annotation quality. This however is not a performance bound: hypothetical human-consensus could reduce error rates half. To obtain model that generalizes better we adapted the pretrained transformer backbone of foundation (SAM) to Cellpose framework. The resulting Cellpose-SAM substantially outperforms and approaches bound. We increase generalization further by making robust channel shuffling, cell size, shot...
Musculoskeletal tissue injuries, including volumetric muscle loss (VML), are commonplace and often lead to permanent disability deformation. Addressing this healthcare need, an advanced biomanufacturing platform, assembled cell-decorated collagen (AC-DC) bioprinting, is invented rapidly reproducibly create living biomaterial implants, using clinically relevant cells strong, microfluidic wet-extruded microfibers. Quantitative analysis shows that the directionality distribution of throughout...
Abstract Musculoskeletal tissue injuries, including the damage and rupture of ligaments tendons, volumetric muscle loss (VML), are exceptionally commonplace often lead to permanent disability deformation. We developed an advanced biomanufacturing platform producing cellularized collagen microfiber implants facilitate functional repair regeneration musculoskeletal soft tissues. This Assembled Cell-Decorated Collagen (AC-DC) bioprinting process rapidly reproducibly forms 3D using clinically...