A5032450006- Metal complexes synthesis and properties
- DNA and Nucleic Acid Chemistry
- Click Chemistry and Applications
- Advanced biosensing and bioanalysis techniques
- Magnetism in coordination complexes
- Lanthanide and Transition Metal Complexes
- Photochemistry and Electron Transfer Studies
- Ferrocene Chemistry and Applications
- Electrochemical Analysis and Applications
- Porphyrin and Phthalocyanine Chemistry
- Organic Light-Emitting Diodes Research
- Organometallic Complex Synthesis and Catalysis
- Inorganic and Organometallic Chemistry
- Molecular Junctions and Nanostructures
- Synthesis and Biological Evaluation
- Photochromic and Fluorescence Chemistry
- Quantum Dots Synthesis And Properties
- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Metal-Catalyzed Oxygenation Mechanisms
- Radical Photochemical Reactions
- Advanced Photocatalysis Techniques
- CO2 Reduction Techniques and Catalysts
- TiO2 Photocatalysis and Solar Cells
- Spectroscopy and Quantum Chemical Studies
Université Libre de Bruxelles
2010-2022
Laboratoire de Chimie Organique
1981-2021
UCLouvain
2014
University of Oxford
2009
Centre National de la Recherche Scientifique
1985-2008
Université Joseph Fourier
2003-2008
Département de Chimie Moléculaire
2007
Institut National de Criminalistique et de Criminologie
2007
Softmat - Chimie des colloïdes, polymères & assemblages complexes
2006
Université Toulouse III - Paul Sabatier
2006
The spectroelectrochemical properties of a novel light switch for DNA, Ru(phen)2(PHEHAT)2+ (phen = 1,10-phenanthroline; PHEHAT 1,10-phenanthrolino[5,6-b]1,4,5,8,9,12-hexaazatriphenylene), are examined and compared to those Ru(phen)2(DPPZ)2+ (DPPZ dipyrido[3,2-a;2',3'-c]phenazine) Ru(phen)2(HAT)2+ (HAT 1,4,5,8,9,12-hexaazatriphenylene). excited luminesces in organic solvents but not water. It is shown that the orbitals involved absorption luminescence spectroscopy same as electrochemistry. In...
The lowest excited state of [Ru(TAP)2(dppz)]2+ (TAP = 1,4,5,8-tetraazaphenanthrene, dppz dipyrido[3,2-a:2′,3′-c]phenazine) 1 is strongly luminescent, even in water, and very oxidizing. Therefore it able to oxidise not only guanosine-5′-monophosphate (GMP), as demonstrated by laser flash photolysis, but also guanine-containing polynucleotides such calf thymus DNA [poly(dG–dC)]2. luminescence quenching was found be faster H2O than D2O, the back reaction, indicating that both processes probably...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRuthenium(II) Complexes with 1,4,5,8,9,12-Hexaazatriphenylene and 1,4,5,8-Tetraazaphenanthrene Ligands: Key Role Played by the Photoelectron Transfer in DNA Cleavage Adduct FormationJean-Paul Lecomte, Andree Kirsch-De Mesmaeker, Martin M. Feeney, John KellyCite this: Inorg. Chem. 1995, 34, 26, 6481–6491Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochemistry and absorption emission spectroscopy of new orthometalated complexes rhodium(III) iridium(III) with the ligands 1,4,5,8-tetraazaphenanthrene 1,4,5,8,9,12-hexaazatriphenyleneP. Didier, I. Ortmans, A. Kirsch-De Mesmaeker, R. J. WattsCite this: Inorg. Chem. 1993, 32, 23, 5239–5245Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November...
Abstract— The nature of the interaction in buffered aqueous solution several homo and heteroleptic ruthenium(II) polypyridyl complexes containing 2,2'‐bipyridine (bpy), 2,2'‐bipyrazine (bpz), 1,10‐phenanthroline (phen), 4,7‐diphenyl‐l,10‐phenanthroline (dip), 3,4,7,8‐tetramethyl‐l,10‐phenanthroline (tmp), 1,4,5,8‐tetraazaphenanthrene (tap), 1,4,5,8,9,12‐hexaazatriphenylene (hat) with calf thymus DNA poly(dA‐dT)‐poly(dA‐dT) (pdAT) has been investigated by steady‐state spectroscopy emission...
Quantum-chemical methods are applied to study the nature of excited states relevant in photophysical processes (absorption and emission) a series polyazaaromatic-ligand-based ruthenium(II) complexes. The electronic optical properties free polyazaaromatic ligands their corresponding complexes determined on basis correlated Hartree-Fock semiempirical approaches. While emission containing small-size ligands, such as 1,10-phenanthroline or 2,2'-bipyridine, arises from manifold metal-to-ligand...
Abstract— The luminescence quenching of ruthenium‐tris‐l,4,5,8‐tetraazaphenanthrene [Ru(tap) 3 2+ ] by nucleotides approaches the diffusion rate only with guanosine‐5′‐monophosphate (GMP), most reducing nucleotide, and leads to an electron transfer production monoreduced complex oxidized base. resulting deprotonated GMP(‐H)radical recombines according a bimolecular equimolar process. pH dependence decay transient reduced complex, in presence oxidant (oxygen or benzoquinone) indicates...
Near-UV or visible light irradiation of Ru(tap)2(bpy)2+ (1) (tap = 1,4,5,8-tetraazaphenanthrene; bpy 2,2'-bipyridyl) in the presence duplex DNA induces formation covalent adducts with guanine. The adduct has been isolated from photomodified as both its nucleotide and nucleobase derivatives by using a combination enzymatic acid hydrolytic procedures conjunction HPLC. Characterization electrospray mass spectrometry NMR spectroscopy shows that two isomeric are formed which exocyclic amino group...
The excited state of the 1,4,5,8-tetra-azaphenanthrene complex, [Ru(TAP)3]2+, which unlike [Ru(phen)3]2+(phen = 1,10-phenanthroline) or [Ru(bipy)3]2+(bipy 2,2′-bipyridyl) is strongly quenched upon binding to poly[d(G–C)], found be much more effective than either [Ru(phen)3]2+ [Ru(bipy)3]2+ in causing cleavage DNA backbone.
Abstract: In traditional scanning electron microscopy/energy dispersive X‐ray analysis of gunshot residue (GSR), one has to cope more and frequently with limitations this technique due the use lead‐free ammunition or lacking heavy metals. New methods for organic components common propellant powder stabilizers were developed based on liquid chromatography coupled tandem mass spectrometry (LC‐MS/MS). A multiple reactions monitoring method was created screening akardite II, ethylcentralite,...
Abstract Transient species formed by photoexcitation (400 nm) of [Ru(dppz)(tap) 2 ] 2+ ( 1 ) (dpp z =dipyrido[3,2‐ a :2′,3′‐ c ]phenazine; tap=1,4,5,8‐tetraazaphenanthrene) in aqueous solution and when intercalated into double‐stranded synthetic polynucleotide, [poly(dG‐dC)] , have been observed on picosecond timescale both visible transient absorption (allowing monitoring the metal complex intermediates) infrared (IR) spectroscopy direct study DNA nucleobases). By contrast with its behavior...
A study of the photophysical mechanisms controlling luminescence lifetimes a series RuII complexes based on same [Ru3+–hat˙–]* luminophore (hat = 1,4,5,8,9,12-hexaazatriphenylene), and extending from monometallic building blocks to polynuclear compounds, is presented, together with relevant spectroscopic redox data. The parameters which characterise these different mechanisms, i.e. radiative nonradiative deactivation rate constants 3MLCT (metal ligand charge transfer) state thermal...
A combination of synthetic methods involving mononuclear precursors predetermined chirality {Δ- or Λ-[Ru(pp)2(CO)2]2+; pp = 2,2'-bipyridine 1,10-phenanthroline} and chromatographic techniques has allowed the isolation meso (ΔΛ) rac (ΔΔ/ΛΛ) diastereoisomers dinuclear complexes [{Ru(pp)2}2(μ-HAT)]4+ {HAT 1,4,5,8,9,12-hexaazatriphenylene}. The enantiomers forms have been separated, characterization all species achieved by NMR CD studies. Additonally, homochiral (Δ3/Λ3) heterochiral (Δ2Λ/Λ2Δ)...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSynthesis and Characterization by Electrospray Mass Spectrometry of a Novel Dendritic Heptanuclear Complex Ruthenium(II)C. Moucheron, A. Kirsch-De Mesmaeker, Dupont-Gervais, E. Leize, Van DorsselaerView Author Information Université Libre de Bruxelles Service Chimie Organique Physique CP 160/08 50, Av. F. D. Roosevelt, B-1050 Brussels, Belgium Laboratoire Spectrométrie Masse Bio-Organique URA 31 CNRS, Louis Pasteur 1, rue Blaise Pascal,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Charge Transfer Luminescent Polymetallic Complexes of Rhodium(III), Iridium(III), and Ruthenium(II) with the Bridging Ligand 1,4,5,8,9,12-HexaazatriphenyleneI. Ortmans, P. Didier, A. Kirsch-De MesmaekerCite this: Inorg. Chem. 1995, 34, 14, 3695–3704Publication Date (Print):July 1, 1995Publication History Published online1 May 2002Published inissue 1 July...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRuthenium complexes with 1,4,5,8-tetraazaphenanthrene. Unusual photophysical behavior of the tris-homoleptic compoundA. Masschelein, L. Jacquet, A. Kirsch-De Mesmaeker, and J. NasielskiCite this: Inorg. Chem. 1990, 29, 4, 855–860Publication Date (Print):February 1, 1990Publication History Published online1 May 2002Published inissue 1 February 1990https://pubs.acs.org/doi/10.1021/ic00329a056https://doi.org/10.1021/ic00329a056research-articleACS...
A new DNA-binding molecule, Ru(tap)2POQ2+, in which a polypyridylruthenium(II) complex is linked to an aminochloroquinoline by flexible chain, has been prepared and characterised (tap = 1,4,5,8-tetraazaphenanthrene POQ corresponds 1,10-phenanthroline aliphatic chain). This regarded as bifunctional because it contains two moieties of different binding modes photoreactivities vs. DNA. The 1H NMR data this compound indicate the presence equilibrium between molecular species. spectroscopic...
Abstract Ruthenium(II) (Ru(II)) complexes are the focus of numerous research works with various applications mainly due to their attractive photophysical and photochemical properties. In biological areas, in particular, they developed as efficient photoprobes or photosensors molecules. More interestingly specific Ru(II) bearing π‐deficient ligands such TAP = 1,4,5,8‐tetraazaphenanthrene, bpz 2,2′‐bipyrazyl HAT 1,4,5,8,9,12‐hexaazatriphenylene exhibit interesting photoreactivity biomolecules...
Self-destruction: Attachment of a photoreactive RuII complex to guanine-containing oligonucleotide has led an innovative biomolecular tool for gene silencing studies. This conjugate can be selectively photo-cross-linked with its complementary strand but undergoes self-inhibition (or "seppuku") process in the presence noncomplementary target (see picture), which is attractive strategy avoid undesired secondary photoeffects. The design specific DNA or RNA damaging agents may achieved by...