A5080879913- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Essential Oils and Antimicrobial Activity
- RNA Interference and Gene Delivery
- Bioactive Compounds and Antitumor Agents
- Photochromic and Fluorescence Chemistry
- Natural product bioactivities and synthesis
- Metal complexes synthesis and properties
- Molecular Junctions and Nanostructures
- Acne and Rosacea Treatments and Effects
- Nail Diseases and Treatments
- Pharmacological Effects of Natural Compounds
- Cancer therapeutics and mechanisms
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Dermatology and Skin Diseases
- Berberine and alkaloids research
- Insect Resistance and Genetics
- Traditional and Medicinal Uses of Annonaceae
- Natural Antidiabetic Agents Studies
- Cell death mechanisms and regulation
- Pharmacological Effects of Medicinal Plants
- Phytochemistry and Biological Activities
- Antifungal resistance and susceptibility
- Cancer Research and Treatments
Translational Health Science and Technology Institute
2021
The University of Texas at Arlington
2021
Vyome Biosciences (India)
2016-2020
University of Massachusetts Amherst
2010-2013
Université Joseph Fourier
2004-2011
Centre National de la Recherche Scientifique
2004-2011
Département de Chimie Moléculaire
2011
University of Calcutta
2010
Jawaharlal Nehru Centre for Advanced Scientific Research
2008
Indian Institute of Science Bangalore
2004-2008
Dengue virus is the flavivirus that causes dengue fever, hemorrhagic disease, and shock syndrome, which are currently increasing in incidence worldwide. protease (NS2B-NS3pro) essential for infection thus a target of therapeutic interest. To date, attention has focused on developing active-site inhibitors NS2B-NS3pro. The flat charged nature NS2B-NS3pro active site may contribute to difficulties suggests strategy identifying allosteric sites be useful. We report an approach allowed us scan...
Abstract Ruthenium(II) (Ru(II)) complexes are the focus of numerous research works with various applications mainly due to their attractive photophysical and photochemical properties. In biological areas, in particular, they developed as efficient photoprobes or photosensors molecules. More interestingly specific Ru(II) bearing π‐deficient ligands such TAP = 1,4,5,8‐tetraazaphenanthrene, bpz 2,2′‐bipyrazyl HAT 1,4,5,8,9,12‐hexaazatriphenylene exhibit interesting photoreactivity biomolecules...
Antimicrobials from natural sources have gained immense importance in recent times to combat the global challenge of antibiotic resistance. Essential oils are implicated antimicrobial action against several species. Here, we screened nine commercially available essential for their activity organisms associated with skin, scalp and nail infections mainly Propionibacterium acnes, Malassezia spp., Candida albicans Trichophyton spp. Among oils, Boswellia serrata oil demonstrated superior all...
The prevalence of drug-resistant pathogenic fungi is a major global health challenge. There an urgent need for novel drugs that can exert potent antifungal activity and overcome resistance. Newly discovered anti-fungal properties existing compounds potentially offer rapid solution to address this persistent threat. We rationalized structures which disrupt the fungal cell membrane could above unmet need. As fatty acids underpin formation stability membranes, we used computational simulations...
Here, we present the synthesis, photochemical, and DNA binding properties of three photoisomerizable azobenzene−distamycin conjugates in which two distamycin units were linked via electron-rich alkoxy or electron-withdrawing carboxamido moieties with azobenzene core. Like parent A, these molecules also demonstrated AT-specific binding. Duplex abilities found to depend upon nature length spacer, location protonatable residues, isomeric state conjugate. The changes duplex efficiency individual...
The use of DNA networks as templates for forming nanoarrays metallic centres shows an exciting potential to generate addressable nanostructures. Inorganic units can be photoactive, electroactive and/or possess magnetic and catalytic properties adopt different spatial arrangements due their varied coordination nature. All these influence both the structure function passive scaffolds provide nanostructures a new platform materials in emerging technologies, such nanotechnology, biosensing or...
We describe here a short and efficient synthetic route for incorporating terpyridine based metal complexes at the 3′-extremity of both single bis-oligonucleotide (bis-ODN) stretches to form novel complex–ODN conjugates. All stranded mono bis-ODN tethered respective duplex ODNs were characterized by circular dichroism spectroscopy UV-Vis melting experiments. Duplexes formed these hybrid complex–DNA conjugates showed around 4–5 °C stabilization with respect unmodified duplexes. Moreover...
Selected sequences of oligodeoxyribonucleotides (ODNs) have been conjugated efficiently with distamycin-based peptides containing reactive cysteine and oxyamine functionalities at the C-terminus. The conjugation was performed easily within 30−60 min, using individual modified oligonucleotide stretches having 5'-d(GCTTTTTTCG)-3', 5'-d(GCTATATACG)-3', 5'-AGCGCGCGCA-3'. Two types linkages were used for making covalent connection: (i) a five-membered thiazolidine ring (ii) an oxime. These...
Abstract The photoreactivity of new Ru II ‐oligonucleotide conjugates is investigated in the presence their complementary strands. goal to determine origins different effects parameters that control photocrosslinking process two Therefore, compounds, either [Ru(tap) 3 ] 2+ or 2 phen] (tap = 1,4,5,8‐tetraazaphenanthrene, phen 1,10‐phenanthroline) with oxidation powers, were tethered linkers 5′‐ 3′‐phosphate end probe strand before hybridization strand. These systems studied by time‐resolved...
We report gas-phase electronic structure calculations on helical peptides that act as scaffolds for imidazole-based hydrogen-bonding networks (proton wires). have modeled various 21-residue polyalanine substituted at regular intervals with histidines (imidazole-bearing amino acids), using a hybrid approach semiempirical method (AM1) peptide and density functional theory (B3LYP) proton wires. computed energy landscapes including barriers Grotthuss-shuttling-type motions though wires supported...
Distamycin-based tetrapeptide (1) was covalently tethered to both ends of the central dihydroxyazobenzene moiety at either 2,2' or 4,4' positions. This afforded two isomeric, distamycin-azobenzene-distamycin systems, 2 (para) and 3 (ortho), them being photoisomerizable. Illumination these conjugates in solution approximately 360 nm induced photoisomerization time course process followed by UV/Vis (1)H NMR spectroscopy. The kinetics thermal reversion various temperatures cis trans isomers...
Caspases comprise a family of dimeric cysteine proteases that control apoptotic programmed cell death and are therefore critical in both organismal development disease. Specific inhibition individual caspases has been repeatedly attempted, but not yet attained. Caspase-9 is an upstream or initiator caspase regulated differently from all other caspases, as interaction with natural inhibitor X-linked apoptosis protein (XIAP)-baculovirus inhibitory repeat 3 (BIR3) occurs at the dimer interface...
An efficient surface anchoring strategy of tolylterpyridine-tagged DNA single strands (ssDNA-ttpy) synthesized on gold electrodes is reported. The method based exchange reactions between Fe(II)bis-terpyridine complexed SAMs and ssDNA-ttpy, allows hybrydization the cDNA strands. Moreover, by using low-current focused ion beam lithography, micropatterned arrays are obtained, homogeneously covered with ssDNA-ttpy. adsorption kinetics as well its hybridization efficiency, was monitored in situ...
Abstract New triterpenoid (I), named reissantiadiol, is isolated among known compounds from the stems of reissantia grahamii.
Abstract Review: 37 refs.
Triple-negative breast cancer (TNBC) is the most malignant subtype of with high heterogeneity, rapid progression, and paucity treatment options. The effective chemotherapeutic drug used to treat TNBC doxorubicin (Doxo) which an anthracycline antibiotic. However, Doxo alters cytosolic calcium dynamics leading drug-resistance condition. aim this study capture alterations in activity various channels pumps during their consequences on that ultimately result resistance.In present study, a...