A5003987902- Retinal Development and Disorders
- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- Intraoperative Neuromonitoring and Anesthetic Effects
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Simulation Techniques and Applications
- Photoreceptor and optogenetics research
- Advanced Queuing Theory Analysis
- Ocular and Laser Science Research
- Visual perception and processing mechanisms
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Intracranial Aneurysms: Treatment and Complications
- Circadian rhythm and melatonin
- Bayesian Methods and Mixture Models
- Retinal and Macular Surgery
- Neurobiology and Insect Physiology Research
- Scheduling and Optimization Algorithms
- Probability and Risk Models
- Optical Imaging and Spectroscopy Techniques
- Statistical Distribution Estimation and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Measurement and Metrology Techniques
- Ophthalmology and Visual Impairment Studies
University of Maryland, Baltimore
2012-2024
Woods Hole Oceanographic Institution
2023
Ljubljana University Medical Centre
2015
University of Maryland Medical Center
2001-2014
University of Baltimore
1998-2008
University of Illinois Urbana-Champaign
1991-2005
University of Mary
2004
Ophthalmology Associates (United States)
2003
Newcastle University
1997-2002
AT&T (United States)
2002
Vocalisation rates were measured from North Atlantic right whales (Eubalaena glacialis) in spring 1999-2000 the Great South Channel and off Cape Cod, USA, summer Bay of Fundy, Canada. Vocalisations classed as either ‘moans’, ‘low-frequency (LF) calls’ or ‘gunshots’. Towed hydrophone recordings (36.1 hours) made 21 encounters where loose aggregations within about 1,000m. Recordings also using acoustic tags attached by suction cups to ten different (29.5 hours). Tags recorded depth data. Moan...
<b>Objective: </b> To determine the sources of vigabatrin-associated visual disturbances in patients treated for epilepsy. <b>Background: Vigabatrin is an extremely effective antiepileptic drug that selectively increases brain gamma-aminobutyric acid (GABA). Several recently developed constricted fields during vigabatrin treatment United Kingdom, indicating possibility GABA-associated retinal dysfunction. <b>Methods: Patients with symptoms chronically at our center underwent evoked...
One approach to the moment-matching problem for phase distributions restrict selection an appropriate subset of distributions. We investigate use mixtures Erlang common order match moments feasible with support on . show that, except special cases, first κ (finite) any nondegenerate distribution can be matched by a mixture (sufficiently high) order. Moreover, we that κ-tuple n-stage or fewer The three-moment-matching is considered in detail. set pairs second and third standardized...
Anterior ischemic optic neuropathy (AION) is caused by sudden loss of vascular supply to retinal ganglion cell (RGC) axons in the anterior portion nerve and a major cause dysfunction. There has been no easily obtainable animal model this disorder. The current study was conducted design novel rodent AION (rAION), enable more detailed disease.A photoembolic stroke developed that directly analogous human AION. Using histologic, electrophysiological, molecular- biological methods, early changes...
Vigabatrin is an antiepileptic drug that, although relatively well tolerated, associated with visual field constriction and other disturbances of unclear origin.We performed a complete neuroophthalmologic examination electrophysiologic studies on 39 patients receiving vigabatrin 11 control patients.Nearly 50% had constricted fields compared patients. Some the also reduced acuity abnormal color vision. In addition, most electroretinographic results, severity which correlated strongly degree...
Electroretinograms (ERGs) were measured in 15 patients with central retinal vein occlusion (CRVO). Seven of the had neovascularization iris (NVI) at time testing, and two developed NVI within one month testing; six did not have or any other form (NV) no longer considered to be risk for NV from their present occlusion. The ERGs recorded as a function stimulus intensity 30-Hz flickering stimulus. A Naka-Rushton-type was fit b-wave amplitudes, intensity, evaluate changes ERG amplitude...
To determine if visual function loss from vigabatrin use recovers after the drug is discontinued.Vigabatrin an effective antiepileptic drug, but it known to cause a variety of changes in function, including reductions field, acuity, color vision, and electroretinogram (ERG) electro-oculogram amplitudes. It not whether these are reversible.Measurements static kinetic fields, ERG were recorded while patients taking again 13 who had discontinued because lack efficacy or field. Most been off for...
Type 2 diabetes develops spontaneously in obese aging rhesus monkeys (Macaca mulatta). This study investigates the association between polymorphonuclear leukocytes and development of retinopathy. Blood pressure plasma glucose levels were determined 15 diabetic 6 nondiabetic monkeys. The total cholesterol, LDL HDL triglycerides just before start animal’s final decline elective necropsy. Retinas incubated for ADPase (labels viable retinal blood vessels) nonspecific esterase neutrophils)...
Nonarteritic anterior ischemic optic neuropathy (NAION) is an nerve (ON) stroke and a leading cause of sudden ON-related vision loss. A primate (p)NAION model crucial to further understanding the clinical disorder can provide information regarding pathophysiology other central nervous system (CNS) axonopathies. In current study, NAION was developed, short-and long-term responses this condition were characterized.pNAION induced with novel photoembolic mechanism. Short-and evaluated by...
The International Society for Clinical Electrophysiology of Vision (ISCEV) standard full-field electroretinography (ERG) describes a minimum protocol clinical testing but encourages more extensive where appropriate. This ISCEV extended an extension the ERG standard, in which methods to record and evaluate growth dark-adapted (DA) b-wave with increasing stimulus energy are described. flashes span range that includes weakest flash required generate reliable DA maximal amplitude....
We present a nonlinear programming (NLP) approach to the problem of matching three moments phase distributions. first discuss formulation and implementation general NLP then consider problems for searching over two families distributions: mixtures Erlang distributions real-parametered continuous Coxian Restricting search select from subset allows us greatly simplify problem, resulting in more efficient predictable procedures. Conversely, restriction also reduces variety algorithm can select....
Until recently, color vision in the peripheral field has been thought to be substantially less developed than central field. Although exact dimensions vary from study study, most estimates of chromatic perception place limit trichromatic at no more 30 degrees fixation; visual is completely blind about 50 eccentricity. Within last 10 years, an increased understanding changing spatial scale led researchers reevaluate what believed function. We now know that virtually every measure can improved...
Leber congenital amaurosis (LCA) is a retinal dystrophy characterized by severe visual loss in infancy and nystagmus. Although most often inherited an autosomal recessive fashion, rare individuals with mutations the cone-rod homeobox gene, CRX, have dominant disease. CRX critical for photoreceptor development acts synergistically leucine-zipper transcription factor, NRL. We report on phenotype of two LCA due to novel, de novo mutations, c.G264T(p.K88N) c.413delT(p.I138fs48), that reduce...
Introduction Polyamidoamine dendrimer nanoparticles (~ 4 nanometers) are inert polymers that can be linked to biologically active compounds. These dendrimers selectively target and accumulate in inflammatory cells upon systemic administration. Dendrimer-linked compounds enable sustained release of therapeutic directly at the site damage. The purpose this study was determine if used optic nerve (ON) ischemic lesion our rodent nonhuman primate models nonarteritic anterior neuropathy (NAION), a...
We study density-function shapes of distributions selected by phase-distribution-selection methods developed in Johnson and Taaffe [2, 3]. In [2], analytic results for matching three moments to mixtures two Erlang common order are presented. [3], nonlinear programming (not necessarily the same order), real-parametered Coxian with support on (0, ∞), phase ∞). this paper, we investigate effect restricting selection above subsets distributions. also illustrate how use 3] changes shapes.
Because of their denseness and tractability, phase (PH) distributions are widely used in probabilistic modeling. However, full exploitation the favorable properties PH requires ability to specify PH-distribution parameters obtain adequate distribution approximations. We combine nonlinear-programming techniques heuristics select mixtures Erlang (a subset family) approximate non-PH distributions. Heuristics number mixed order each distribution, both which have an important effect on range that...
Cross-sectional psychophysical and electrophysiologic studies of aging indicate that visual function declines only slightly or not at all until age 50–60, which time the decline in rapidly accelerates. This accelerated loss may reflect an increased rate natural cellular degradation, it proportion subclinical pathology presumed normal older population. paper provides a critical review changes occur with age. The results this have implications for both definition age-matched control groups...