A5069287021- Nanoparticle-Based Drug Delivery
- Ultrasound and Hyperthermia Applications
- Radiation Therapy and Dosimetry
- Characterization and Applications of Magnetic Nanoparticles
- Microfluidic and Bio-sensing Technologies
- Congenital Heart Disease Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Iron Metabolism and Disorders
- Pulmonary Hypertension Research and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Cancer Research and Treatments
- Forensic Toxicology and Drug Analysis
- Sarcoma Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Electromagnetic Fields and Biological Effects
- Ultrasound and Cavitation Phenomena
- Respiratory Support and Mechanisms
- scientometrics and bibliometrics research
- Adrenal and Paraganglionic Tumors
- Neurological Complications and Syndromes
- Magnetic properties of thin films
- Electrostatics and Colloid Interactions
- COVID-19 Clinical Research Studies
- Drug-Induced Adverse Reactions
- Asthma and respiratory diseases
Dartmouth College
2009-2025
Oregon Health & Science University
2022-2024
Stanford University
2017-2021
Stanford Medicine
2015-2020
Hanover College
2013
Dartmouth–Hitchcock Medical Center
2009
The activation of magnetic nanoparticles (mNPs) by an alternating field (AMF) is currently being explored as technique for targeted therapeutic heating tumors. Various types superparamagnetic and ferromagnetic particles, with different coatings targeting agents, allow tumor site type specificity. Magnetic nanoparticle hyperthermia also studied adjuvant to conventional chemotherapy radiation therapy. This review provides introduction some the relevant biology materials science involved in...
Recently, heat generated by iron oxide nanoparticles (IONPs) stimulated an alternating magnetic field (AMF) has shown promise in the treatment of cancer. To determine mechanism nanoparticle-induced cytotoxicity, physical association cancer cells and must be determined. We have used transmission electron microscopy (TEM) to define time dependent cellular uptake intratumorally administered dextran-coated, core-shell configuration IONP having a mean hydrodynamic diameter 100-130 nm murine...
Purpose: The purpose of this study was to examine the therapeutic effect magnetic nanoparticle hyperthermia (mNPH) combined with systemic cisplatin chemotherapy in a murine mammary adenocarcinoma model (MTGB).Materials and methods: An alternating field (35.8 kA/m at 165 kHz) used activate 110 nm hydroxyethyl starch-coated nanoparticles (mNP) thermal dose 60 min 43 °C. Intratumoral mNP were delivered 7.5 mg Fe/cm3 tumour (four equal quadrants). Intraperitoneal 5 mg/kg body weight administered...
Hyperthermia therapy for cancer treatment seeks to destroy tumors through heating alone or combined with other therapies at elevated temperatures between 41.8 and 48 °C. Various forms of cell death including apoptosis necrosis occur depending on temperature time. Effective tumoricidal effects can also be produced by inducing damage the tissue vasculature stroma; however, surrounding normal must spared a large extent. Magnetic nanoparticles have been under experimental investigation in recent...
Purpose: The purpose of this study was to compare the efficacy iron oxide/magnetic nanoparticle hyperthermia (mNPH) and 915 MHz microwave at same thermal dose in a mouse mammary adenocarcinoma model. Materials methods: A equivalent 60 min 43 °C (CEM60) delivered syngeneic flank tumour (MTGB) via mNPH or locally microwaves. generated with ferromagnetic, hydroxyethyl starch-coated magnetic nanoparticles. Following mNP delivery, mouse/tumour exposed an alternating field (AMF). treatment by...
Abstract Background Recent consternation over the number of unfilled Pediatric Anesthesiology fellowship positions in United States compelled us to assess change ratio fellows graduating anesthesiology residents 14‐year period between 2008 and 2022. We also sought report total trends annual applicants relative Accreditation Council for Graduate Medical Education (ACGME)‐accredited by specialty. Methods used publicly available resources, including ACGME Data Resource Books, National Resident...
Distinct magnetic nanoparticle designs can have unique spectral responses to an AC field in a technique called the spectroscopy of Brownian motion (MSB). The spectra particles been measured using desktop spectrometers and vivo measurements. If multiple particle types are present region interest, signatures allow for simultaneous quantification various particles. We demonstrate such potential experimentally with up three types. This ability concurrently detect will enable new biomedical applications.
Iron oxide nanoparticles present a promising alternative to conventional energy deposition-based tissue therapies. The success of such as therapeutic for diseases like cancer, however, depends heavily on the particles' ability localize tumor well provide minimal toxicity surrounding tissues and key organs those involved in reticuloendothelial system (RES). We here results long term clearance study where mice injected intravenously with 2 mg Fe 100 nm dextran-coated iron were sacrificed at 14...
This cross-sectional study examines the association between article citations, Altmetric attention scores, and cumulative page views of pediatric research articles from 4 high-impact medical journals.
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. While the primary risk factor for COPD cigarette smoke exposure, vitamin D deficiency has been epidemiologically implicated as in progressive development COPD-associated emphysema. Because difficulties inherent to studies involving multiple factors progression humans, we developed murine model which study separate combined effects exposure. During 16-week period, mice were exposed one four...
The success of magnetic nanoparticle (mNP)-based diagnostic and therapeutic techniques is dependent upon how the mNP are distributed in vivo. potential efficacy timing a given treatment or test largely determined by number nanoparticles each tissue microscopic compartment: e.g., intravascular extravascular spaces, interstitial space, cell surface cytoplasm. Techniques for monitoring these cell-level interactions generally require harvesting destruction tissues cells at time point interest....
USP18 (ubiquitin-specific protease 18) removes ubiquitin-like modifier interferon stimulated gene 15 (ISG15) from conjugated proteins. null mice in a FVB/N background develop tumors as early 2 months of age. These are leiomyosarcomas and thus represent new murine model for this disease. Heterozygous +/− were bred to generate wild-type, heterozygous homozygous cohorts. Tumors characterized immunohistochemically two cell lines derived independent tumors. Cell karyotyped their responses...
Advances in magnetic nanoparticle hyperthermia are opening new doors cancer therapy. As a standalone or adjuvant therapy this modality has the opportunity significantly advance thermal medicine. Major advantages of using magnetite (Fe<sub>3</sub>O<sub>4</sub>) nanoparticles their highly localized power deposition and fact that alternating fields (AMF) used to excite them can penetrate deeply into body without harmful effect. One limitation, however, which hinders technology, is problem...
Recent advances in nanotechnology have allowed for the effective use of iron oxide nanoparticles (IONPs) cancer imaging and therapy. When activated by an alternating magnetic field (AMF), intra-tumoral IONPs been at controlling tumor growth rodent models. To accurately plan assess IONP-based therapies clinical patients, noninvasive quantitative technique assessment IONP uptake biodistribution will be necessary. Proven techniques such as confocal, light electron microscopy, histochemical...
It is established that heat can enhance the effect of radiation cancer treatment. Due to ability localize thermal energy using nanoparticle hyperthermia, as opposed other, less targeted, hyperthermia modalities, it appears such enhancement could be accomplished without complications normally associated with systemic or regional hyperthermia. This study employs non-curative (suboptimal), doses and radiation, in an effort determine therapeutic potential for IONP radiation. Methods: MTG-B...
One of the greatest challenges nanoparticle cancer therapy is delivery adequate numbers nanoparticles to tumor site. Iron oxide (IONPs) have many favorable qualities, including their nontoxic composition, wide range diameters in which they can be produced, cell-specific cytotoxic heating that results from absorption energy a nontoxic, external alternating magnetic field (AMF), and variety functional coatings applied. Although IONPs delivered via an intra-tumoral injection some tumors,...
Hyperthermia, as an independent modality or in combination with standard cancer treatments such chemotherapy and radiation, has been established vitro vivo effective treatment. However, despite efforts over the past 25 years, therapies have never optimized widely-accepted clinically. Although methods continue to improve, conventionally-delivered heat (RF, ultrasound, microwave etc) can not be delivered a tumor selective manner. The development of antibody-targeted, even nontargeted,...
Magnetic nanoparticles excited by alternating magnetic fields (AMF) have demonstrated effective tumor-specific hyperthermia. This treatment is as a monotherapy well therapeutic adjuvant to chemotherapy and radiation. Iron oxide been shown, so far, be non-toxic, are the exciting AMF when used at moderate levels. Although higher levels of can more effective, depending on type iron use, these field strengths and/or frequencies induce normal tissue heating toxicity. Thus, use exhibiting...
The predicted success of nanoparticle based cancer therapy is due in part to the presence inherent leakiness tumor vascular barrier, so called enhanced permeability and retention (EPR) effect. Although EPR effect present varying degrees many tumors, it has not resulted consistent level nanoparticle-tumor uptake enhancement that was initially predicted. Magnetic/iron oxide nanoparticles (mNPs) have positive qualities, including their inert/nontoxic nature, ability be produced various sizes,...
Hyperthermia has been shown to be an effective radiosensitizer. Its utility as a clinical modality limited by minimally selective tumor sensitivity and the inability delivered in tumor-specific manner. Recent vivo studies (rodent human) have that cancer cell-specific cytotoxicity can effectively safely via iron oxide magnetic nanoparticles (mNP) appropriately matched noninvasive alternating field (AMF). To explore radiosensitization potential of mNP hyperthermia we used syngeneic mouse...