A5007589401- Polyamine Metabolism and Applications
- Autophagy in Disease and Therapy
- Cannabis and Cannabinoid Research
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Reproductive biology and impacts on aquatic species
- Advanced Glycation End Products research
- Sperm and Testicular Function
- Photochromic and Fluorescence Chemistry
- Luminescence and Fluorescent Materials
- Bladder and Urothelial Cancer Treatments
- Kruppel-like factors research
- Pharmacological Effects of Natural Compounds
- Animal Genetics and Reproduction
- GABA and Rice Research
- Trace Elements in Health
- Probiotics and Fermented Foods
- Biopolymer Synthesis and Applications
- Reproductive Biology and Fertility
- Polydiacetylene-based materials and applications
- Aquaculture disease management and microbiota
- Genomics, phytochemicals, and oxidative stress
- Amino Acid Enzymes and Metabolism
Sichuan Agricultural University
2023-2025
Ministry of Agriculture and Rural Affairs
2023
Soochow University
2019
Spermidine have been reported a role in antioxidative, antiaging, and antiinflammatory. Oxidative stress causes granulosa cell (GC) apoptosis, follicular atresia, impairs poultry reproductive functions. Studies found that autophagy is the protective mechanism against antioxidant apoptosis cells. However, relationship between spermidine-induced autophagy, oxidative stress, goose GCs remains unclear. In this study, we investigated to mediate spermidine effects on alleviation of GCs. Follicular...
Spermidine is a naturally occurring polyamine compound that has many biological functions, such as inducing autophagy and anti-inflammatory anti-aging effects. can affect follicular development thus protect ovarian function. In this study, ICR mice were fed exogenous spermidine drinking water for three months to explore the regulation of function by spermidine. The results showed number atretic follicles in ovaries spermidine-treated was significantly lower than control group. Antioxidant...
Introduction Intestinal health is very important to the of livestock and poultry, even a major determining factor in performance poultry production. Spermidine type polyamine that commonly found variety foods, can resist oxidative stress, promote cell proliferation regulate intestinal flora. Methods In this study, we explored effects spermidine on under physiological states or stress conditions by irrigation with intraperitoneal injection 3-Nitropropionic acid (3-NPA) Sichuan white goose....
Abstract Copper exposure poses potential detrimental effects on both public and ecosystem health. Spermidine, an antioxidant, has shown promise in reducing oxidative stress inflammation within the liver. However, its specific role mitigating copper‐induced hepatic cuproptosis disturbances copper metabolism remains unexplored. Consequently, this research aims to investigate examine impact of spermidine related metabolism. In study, we established a model liver toxicity by feeding C57BL/6 mice...
Spermidine is a class of biologically active organic small molecules that play an important role in maintaining intestinal homeostasis. The specific objective this study was to explore the effects spermidine on morphology, metabolites, and microbial diversity mice. We showed 0.3 mmol/L significantly promoted growth ileal villi (p < 0.05), 3.0 increased body weight mice jejunum 0.05). 16S rDNA sequencing results indicated affected balance flora by increasing abundance Lactic acid bacteria...
Abstract Autophagy can inhibit ovarian senescence induced by oxidative stress and regulate follicle development atresia, but its mechanism is still unclear. Exogenous spermidine induce autophagy scavenge reactive oxygen species (ROS). In this experiment, in Sichuan white geese ovaries follicular granulosa cells (GCs) was caused 3-nitropropionic acid (3-NPA) added to explore the effect of exogenous inducing inhibiting vivo vitro. Research results showed that putrescine, spermine contents...
Oxidative stress is the major culprits responsible for ovarian dysfunction by damaging granulosa cells (GCs). Ferritin heavy chain (FHC) may participate in regulation of function mediating GCs apoptosis. However, specific regulatory FHC follicular remains unclear. Here, 3-nitropropionic acid (3-NPA) was utilized to establish an oxidative model Sichuan white geese. To explore effects on and apoptosis primary geese interfering or overexpressing gene. After transfection siRNA-FHC 60 h,...
Azobenzene (Azo) units were successfully introduced into perylene bisimide (PBI) structures in order to realize the photocontrolling of morphology supramolecular assembly PBI by a photoisomerization process. A total three Azo-functionalized derivatives (PBI1, PBI2, and PBI3) with different alkyl chain lengths designed synthesized imidization 3,4,9,10-perylene tetracarboxylic dianhydride corresponding amines. The these compounds characterized proton nuclear magnetic resonance (1H NMR)...
Wheat germ is known for its antioxidant, anti-inflammatory, and disease resistance properties in animals. However, effect on the gut of Sichuan white geese remains unclear.
To investigate the relationship between polyamine metabolism and reproductive hormones in ovarian follicles of Sichuan white geese, content levels gene expression related to metabolism, steroidogenesis steroid hormone receptors were detected by HPLC, ELISA RT-qPCR. The results showed that overall trend spermidine spermine first increased then decreased with increasing follicle size, highest F3 F5 (P < 0.05). Levels putrescine estradiol-17β (E2) hierarchical significantly lower than...