A5040024539- Chronic Kidney Disease and Diabetes
- Cardiovascular Health and Disease Prevention
- Immunotherapy and Immune Responses
- Antiplatelet Therapy and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Education, Healthcare and Sociology Research
- Monoclonal and Polyclonal Antibodies Research
- Social and Educational Sciences
- Family and Disability Support Research
- Renal Diseases and Glomerulopathies
- Peptidase Inhibition and Analysis
- Adolescent and Pediatric Healthcare
- Clinical practice guidelines implementation
- Educational Assessment and Improvement
- Heparin-Induced Thrombocytopenia and Thrombosis
- Diabetes Management and Research
- RNA Interference and Gene Delivery
- Down syndrome and intellectual disability research
- Dialysis and Renal Disease Management
- Lipoproteins and Cardiovascular Health
- Adipokines, Inflammation, and Metabolic Diseases
- Education, Leadership, and Health Research
- Venous Thromboembolism Diagnosis and Management
Steno Diabetes Centers
2022-2024
German Rheumatism Research Centre
2015-2021
Charité - Universitätsmedizin Berlin
2015-2021
Aarhus University Hospital
2016
University College South Denmark
2014
Background Diabetic kidney disease is a major cause of morbidity and mortality. Dysregulated turnover collagen type III associated with development fibrosis. We investigated whether degradation product (C3M) was risk marker for progression chronic (CKD), occurrence cardiovascular (CVD), mortality during follow up in people 2 diabetes (T2D) microalbuminuria. Moreover, we C3M correlated markers inflammation endothelial dysfunction at baseline. Methods measured serum (sC3M) urine (uC3M) 200...
Abstract Introduction: Health related quality of life (HRQOL) is markedly reduced in hemodialysis patients compared to the general population. We investigated course self‐reported HRQOL over time and association with selected factors, focusing on changes glomerular filtration rate (GFR). Methods: Eighty‐two newly started from SAFIR cohort filled out Kidney Disease Quality Life Short Form Version 1.3 (KDQOL‐SF TM ) questionnaire at baseline, 6 12 months. The study was a randomized,...
This study focuses on the contributions of a community and campus based day programme to quality life participants with severe level intellectual disability from perspective parents staff. Qualitative interviews were carried out staff explore contribution that two programmes had participants' in 6 months since began. Schalock Keith's Quality Life Questionnaire was administered supplement qualitative data. Results indicated contributed more over preceding than programme. revealed new-found...
Peptide-based therapy is a promising strategy for antigen-specific immunosuppression to treat or even heal autoimmune diseases with significantly reduced adverse effects compared conventional therapies. However, there has been no major success due the drawbacks of native peptides, i.e., limited bioavailability. Considering importance and limitations peptide-based therapies treatment diseases, we designed constructed oligoglycerol (OG)- polyglycerol (PG)-based peptide conjugates. They were...
Therapeutic treatment options for chronic autoimmune disorders such as multiple sclerosis (MS) rely largely on the use of non-specific immunosuppressive drugs, which are not able to cure disease. Presently, approaches induce antigen-specific tolerance a therapeutic approach; example, by peptide-based tolerogenic 'inverse' vaccines have regained great interest. We previously shown that coupling peptides carriers can enhance their capacity regulatory T cells in vivo.In this present study, we...
Abstract The treatment of autoimmune disorders such as multiple sclerosis (MS) so far relies largely on the use non-specific immunosuppressive drugs, which are not able to cure disease. Presently, approaches induce antigen-specific tolerance e.g. by peptide-based tolerogenic “inverse” vaccines regain interest. We previously have shown that coupling peptides carriers can enhance their capacity regulatory T cells in vivo . here investigated an experimental encephalomyelitis (EAE) model for...
Abstract Background: Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory biomarker strongly linked with cardiovascular disease in diabetes. By investigating its association platelet aggregation levels and carotid plaque thickness, we can potentially improve the characterization of pathophysiology type 1 (T1D) 2 diabetes (T2D). Methods: SuPAR was measured post-hoc plasma collected two cross-sectional studies including 1) individuals T1D 2) T2D without known disease....