A5002932105- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Dialysis and Renal Disease Management
- Membrane-based Ion Separation Techniques
- Membrane Separation Technologies
- Heart Failure Treatment and Management
- Renal function and acid-base balance
- Hemodynamic Monitoring and Therapy
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Electrolyte and hormonal disorders
- Chronic Kidney Disease and Diabetes
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Nanopore and Nanochannel Transport Studies
- Vitamin K Research Studies
- Potassium and Related Disorders
- Cerebrovascular and Carotid Artery Diseases
- Muscle and Compartmental Disorders
- Pharmacological Effects and Toxicity Studies
- Pregnancy and Medication Impact
- Cardiac Structural Anomalies and Repair
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Heart Rate Variability and Autonomic Control
Aarhus University Hospital
2015-2025
Aarhus University
2013-2025
University of Oxford
2019-2022
Nanyang Technological University
2021-2022
Aalborg University Hospital
2015
Pfizer (France)
2004
Background: Renal denervation (RDN), treating resistant hypertension, has, in open trial design, been shown to lower blood pressure (BP) dramatically, but this was primarily with respect office BP. Method: We conducted a SHAM-controlled, double-blind, randomized, single-center establish efficacy data based on 24-h ambulatory BP measurements (ABPM). Inclusion criteria were daytime systolic ABPM at least 145 mmHg following 1 month of stable medication and 2 weeks compliance registration. All...
Arterial calcification is associated with cardiovascular mortality in dialysis patients. Active matrix Gla protein (MGP) a vitamin K-dependent inhibitor of arterial calcification. Elevated plasma concentrations inactive MGP, i.e. dephosphorylated-uncarboxylated MGP (dp-ucMGP), are prevalent inactivity might contribute to We investigated whether K supplementation had an effect on chronic patients.In 2-year, double-blind, placebo-controlled intervention trial, 48 patients were randomized...
Background Estimated pulse wave velocity (ePWV) calculated by equations using age and blood pressure has been suggested as a new marker of mortality cardiovascular risk. However, the prognostic potential ePWV during long‐term follow‐up in patients with symptoms stable angina remains unknown. Methods Results In this study, was 25 066 without diabetes, previous myocardial infarction (MI), stroke, heart failure, or valvular disease (mean 63.7±10.5 years, 58% male) pectoris undergoing elective...
Osmotically assisted reverse osmosis (OARO) has shown great potential for low-cost and energy-efficient brine management. However, its performance can be significantly limited by membrane fouling. Here, we performed the first time a comprehensive study on OARO fouling, explored associated fouling mechanisms, evaluated reversibility via simple physical cleaning strategies. First, internal at draw (permeate) side was to insignificant. Flux behavior in short-term operation correlated both...
In this case report, a 72-year-old male haemodialysis patient with severe chronic kidney disease-associated pruritus (CKD-aP) was given difelikefalin (DFK) 50 μg × 3/week after unsuccessful standard therapy including fatty cream, steroids, antihistamines, gabapentinoids, and UV-light. CKD-aP verified by dermatologist before DFK given. After three weeks, had improved markedly. The worst itch numeric rate scale (range: 0-10) dropped to 0 from 7-8 prior DFK. caused drowsiness which disappeared...
The SphygmoCor is used for noninvasive assessment of ascending aortic blood pressure (BP). However, the validity transfer function has not been tested in an exclusively type 2 diabetic patient sample. Calibration with systolic (SBP) and diastolic (DBP) brachial BP previously associated substantial imprecision central estimates. We hypothesized that different calibration strategies might improve accuracy estimated BPs.In 34 patients diabetes we SBP DBP using device compared these data...
Central blood pressure (BP) can be assessed noninvasively based on radial tonometry and may potentially a better predictor of clinical outcome than brachial BP. However, the validity obtained estimates has never been examined in patients with chronic kidney disease (CKD). Here we compared invasive aortic systolic BP (SBP) estimated central SBP by artery influence renal function arterial stiffness this relationship. We evaluated 83 stage 3 to 5 CKD (mean glomerular filtration rate [eGFR] 30...
Central blood pressure (BP) has attracted increasing interest because of a potential superiority over brachial BP in predicting cardiovascular morbidity and mortality. Several devices estimating central noninvasively are now available. The aim our study was to determine the validity Arteriograph, cuff-based, oscillometric device, patients with type 2 diabetes. We measured invasively compared it Arteriograph-estimated values 22 diabetic referred elective coronary angiography. difference...
THE duration of life after an acute coronary-artery occlusion has long been regarded as brief, and it is only in recent years that the more optimistic viewpoint pronounced 1912 by Herrick1 justified. In increasing numbers, cases have reported survivals for seventeen, twenty-four even forty years.2 3 4 5 As explanation this change prognosis, suggested5 myocardial infarction being diagnosed mild atypical forms would dismissed ago so-called "acute indigestion" or never brought to attention a...
Background The present study investigated whether changes in gene expression the right ventricle following pulmonary hypertension can be attributed to hypoxia or pressure loading. Methodology/Principal Findings To distinguish from pressure-induced alterations, a group of rats underwent banding trunk (PTB), sham operation, were exposed normoxia chronic, hypobaric hypoxia. Pressure measurements performed and was analyzed by Affymetrix GeneChip, selected genes confirmed quantitative PCR...
It was hypothesized that dysregulation of renal epithelial sodium channel (ENaC) subunits and/or 11beta-hydroxysteroid dehydrogenase (11betaHSD2) may play a role in the increased retention liver cirrhosis (LC). Experimental LC induced rats by CCl(4) (1 ml/kg, intraperitoneally, twice week) for 12 wk (protocol 1) or 11 2). In both protocols, one group with showed significantly decreased urinary excretion and Na/K ratio (group A), whereas second exhibited normal B) compared controls, even...
It has been documented that preservation of residual renal function in dialysis patients improves quality life as well survival. Clinical trials on strategies to preserve are clearly lacking. While waiting for more results from clinical trials, will benefit clinicians being aware available knowledge. The aim this review was offer an update current evidence assisting doctors practice.
Objectives: To investigate, whether renal denervation (RDN) improves arterial stiffness, central blood pressure (C-BP) and heart rate variability (HRV) in patients with treatment resistant hypertension.Methods: ReSET was a randomized, sham-controlled, double-blinded trial (NCT01459900). RDN performed by single experienced operator using the Medtronic unipolar Symplicity FlexTM catheter. C-BP, carotid-femoral pulse wave velocity (PWV), HRV were obtained at baseline after six months...
Abstract Introduction: Health related quality of life (HRQOL) is markedly reduced in hemodialysis patients compared to the general population. We investigated course self‐reported HRQOL over time and association with selected factors, focusing on changes glomerular filtration rate (GFR). Methods: Eighty‐two newly started from SAFIR cohort filled out Kidney Disease Quality Life Short Form Version 1.3 (KDQOL‐SF TM ) questionnaire at baseline, 6 12 months. The study was a randomized,...