A5015199718- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Palliative Care and End-of-Life Issues
- Renal and Vascular Pathologies
- Renal function and acid-base balance
- MRI in cancer diagnosis
- Liver Disease Diagnosis and Treatment
- Patient Dignity and Privacy
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Organ Donation and Transplantation
- Birth, Development, and Health
- Alcohol Consumption and Health Effects
- Apelin-related biomedical research
- Thermoregulation and physiological responses
- Patient-Provider Communication in Healthcare
- Medical and Health Sciences Research
- Tuberous Sclerosis Complex Research
- Hemodynamic Monitoring and Therapy
- Healthcare Decision-Making and Restraints
- Angiogenesis and VEGF in Cancer
- Peroxisome Proliferator-Activated Receptors
- Genetic and Kidney Cyst Diseases
- Cannabis and Cannabinoid Research
- Chronic Kidney Disease and Diabetes
Aarhus University Hospital
2015-2025
Aarhus University
2014-2025
Purpose Determine the reproducibility of renal artery blood flow (RABF) and blood‐oxygenation level dependent (R 2 *) in patients with chronic kidney disease (CKD) healthy controls. Materials Methods RABF R * were measured 11 CKD 9 controls twice 1‐ to 2‐week interval. cortex medulla determined after breathing atmospheric air 100% oxygen. Reproducibility was evaluated by coefficients variation (CV), limits agreements intra‐class coefficient calculated variance components maximum likelihood...
Central blood pressure (BP) can be assessed noninvasively based on radial tonometry and may potentially a better predictor of clinical outcome than brachial BP. However, the validity obtained estimates has never been examined in patients with chronic kidney disease (CKD). Here we compared invasive aortic systolic BP (SBP) estimated central SBP by artery influence renal function arterial stiffness this relationship. We evaluated 83 stage 3 to 5 CKD (mean glomerular filtration rate [eGFR] 30...
Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent hereditary and the fourth most common cause of failure. Patients may be aware their condition from an early age or discover it unexpectedly, with varying levels familial knowledge about disease. This chronic presents significant challenges for healthcare professionals. The study aimed to investigate how people ADPKD experience participation in dedicated clinic support needs managing everyday life. Methods: A...
Abstract Aim To investigate the decisional needs in Denmark of people with kidney failure, relatives, and health professionals when planning end‐of‐life care. Design A qualitative interview study. Methods Individual semi‐structured interviews were carried out relatives from November 2021 to June 2022. Malterud's systematic text condensation was used analyse transcripts. Results total 13 patients, 10 12 interviewed. Overall, four concepts agreed on: (1) Talking about end life is difficult,...
Abstract Aim To describe the development of a shared decision making intervention for planning end‐of‐life care patients with kidney failure, their relatives and health professionals in services. Background End‐of‐life conversations within standard disease management consultations are challenging professionals. is about difficult decisions advance, which why need skills to be able initiate conversations. Health report needing more raise issue options want discuss issues important them future...
Key Points This study developed a urine acid/base score to assess tubular acid excretion capacity and identify early retention in CKD. The results show that signs of (a low score) are associated with higher risk for CKD progression. Future research should address if can be improved this translates into clinically meaningful effects. Background Acidosis is exacerbated loss kidney function Currently, status assessed by plasma measures, although organ-damaging covert acidosis, subclinical may...
Excretion of the tubular protein liver fatty acid binding (L-FABP) is a potential novel biomarker renal dysfunction. We examined whether urine L-FABP excretion adds prognostic information to well-established risk markers, blood pressure (BP), albumin and baseline GFR, regarding progression chronic kidney disease (CKD). In prospective study design cohort 74 stage 3-4 CKD patients (age 61 ± 13 years) were included. Glomerular filtration ratio (GFR, 51Cr-EDTA-clearance), 24-hour ambulatory BP,...
<b><i>Introduction:</i></b> Chronic kidney disease (CKD) is associated with cardiovascular (CVD) and death. Albuminuria an established risk factor, but additional biomarkers predicting CKD progression or CVD are needed. Arterial stiffness easily measurable parameter that has been mortality. We evaluated the ability of carotid-femoral pulse wave velocity (PWV) urine albumin-creatinine (UAC) ratio to predict progression, events, mortality in a cohort patients....
Progression of chronic kidney disease (CKD) may be accelerated by tissue hypoxia due to impaired blood supply. This could induced small artery narrowing resulting in abnormally high intrarenal vascular resistance (RVR). We investigated whether a reduction RVR achieved adding vasodilating medical therapy (AVT) is superior nonvasodilating (AnonVT) regarding oxygenation and preservation function.Eighty-three grade 3 4 CKD patients [estimated glomerular filtration rate (GFR) 34.6 ml/min per 1.73...
Established essential hypertension is associated with increased arterial stiffness and peripheral resistance, but the extent of vascular changes in persons genetically predisposed for uncertain.Participants from Danish Hypertension Prevention Project (DHyPP) (both parents hypertensive) (n = 95, 41 ± 1 years, 53% men) were compared available spouses 45, years) using measurements ambulatory blood pressure (BP), left ventricular mass index (LVMI), pulse wave velocity, central BP augmentation...
Blood pressure (BP) control is important in chronic kidney disease (CKD), but a reduction brachial BP may not mirror changes central aortic (cBP) during antihypertensive medication. We hypothesize that fall cBP better reflected enhanced vasodilation treatment (EVT) compared with reduced (RVT) because of different hemodynamic actions these interventions.Eighty-one hypertensive CKD stage 3-4 patients (mean measured glomerular filtration rate 36 ml/min per 1.73 m2) were randomized to either EVT...
<b><i>Background:</i></b> Central blood pressure (BP) assessed noninvasively considerably underestimates true invasively measured aortic BP in chronic kidney disease (CKD) patients. The difference between the estimated and increases with decreasing glomerular filtration rates (eGFR). present study investigated whether calcification affects noninvasive estimates of central BP. <b><i>Methods:</i></b> Twenty-four patients CKD stage 4–5 undergoing...
Summary Large artery stiffness and small structural changes are both cardiovascular risk factors. Arterial increases with age blood pressure ( BP ), but it is unclear in which way large pulse wave velocity PWV ) peripheral vascular resistance related whether has any influence. In a cross‐sectional study, forearm minimum R min was compared emphasis on the impact of age. Normotensive n = 53) untreated hypertensive 23) subjects were included based 24‐h measurements. Age ranged from 21 to 79...
Abstract Background and Aims Shared decision-making is recommended for dialysis choice, whereby patients are supported in making decisions regarding modality together with healthcare professionals. The intervention ‘Shared decision choice’ has been a part of usual care at two hospitals Denmark since 2018. aim this study was to describe the choice outcomes kidney failure, who received intervention. Method An observational longitudinal cohort conducted. Data collected retrospectively from 2018...
Kidney failure is associated with a high disease burden and mortality rates. National international guidelines recommend health professionals involve patients kidney in making decisions about end-of-life care, but implementation of these conversations within services varies. We developed the DESIRE (ShareD dEciSIon-making for failuRE to improve care) intervention from our studies investigating multiple decision maker needs experiences care services. The intervention's three components are...