A5053216151- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Phytochemistry and Biological Activities
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Nigella sativa pharmacological applications
- Biochemical Acid Research Studies
- Saffron Plant Research Studies
- Effects and risks of endocrine disrupting chemicals
- Chemotherapy-induced organ toxicity mitigation
- Carcinogens and Genotoxicity Assessment
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Bioactive natural compounds
- Tea Polyphenols and Effects
- Natural product bioactivities and synthesis
- Research on Leishmaniasis Studies
- Vector-borne infectious diseases
- Electrolyte and hormonal disorders
- Bipolar Disorder and Treatment
- Free Radicals and Antioxidants
- Phytochemical and Pharmacological Studies
- Gestational Diabetes Research and Management
- Trypanosoma species research and implications
- Tryptophan and brain disorders
Al-Azhar University
2014-2024
Soliman Fakeeh Hospital
2017-2024
Taibah University
2005-2017
Al-Azhar University
2013
King Abdul Aziz University Hospital
2009
Phthalates are abundantly produced plasticizers, and dibutyl phthalate (DBP) is the most widely used derivative in various consumer products medical devices. This study was conducted to further explore potential testicular toxicity of DBP adult rats elucidate underlying mechanisms. Adult male albino were treated orally with at doses 0, 200, 400, or 600 mg/kg/day for 15 consecutive days. Testicular weight, sperm count, motility significantly decreased. Treatment decreased serum...
The present study investigated the in vitro hypoglycemic activity of basil (Ocimum basilicum) aqueous extract. Preliminary phytochemical screening extract revealed presence reducing sugars, cardiac glycosides, tannins, saponins, flavonoids and steroids. total polyphenols content (TPC), (FC), percentage diphenylpicrylhydrazyl (DPPH( · )) radical inhibition antioxidant status (TAS) were estimated. FC was 41 ± 2.2 rutin/g dry extract, TPC 146 5.26 mg catechin/g TAS 5.12 0.7 mmol/L. %DPPH( )...
Bisphenol A (BPA) is one of the highest volume chemicals produced worldwide. BPA used in production polycarbonate plastics and epoxy resins manufacturing plastic baby bottles lining food cans. In this study, we investigated BPA-induced testicular oxidative stress perturbation mitochondrial marker enzymes male albino rats its amelioration by α-lipoic acid (LA). Rats were administered a dose (10 mg/kg body weight) orally for 14 days. This resulted decreased testes weight, total protein...
This study aims to comprehensively explore the phytoconstituents as well investigate different biological activities of Chasmanthe aethiopica (Iridaceae) for first time. Metabolic profiling leaf methanol extract C. (CAL) was carried out using HPLC-PDA-ESI-MS/MS. Twenty-nine compounds were annotated belonging various phytochemical classes including organic acids, cinnamic acid derivatives, flavonoids, isoflavonoids, and fatty acids. Myricetin-3-O-rhamnoside major compound identified. GLC/MS...
Tamoxifen citrate (TAM), is widely used for treatment of breast cancer. It showed a degree hepatic carcinogenesis. The purpose this study was to elucidate the antioxidant capacity green tea (Camellia sinensis) extract (GTE) against TAM-induced liver injury. A model injury in female rats done by intraperitoneal injection TAM dose <TEX>$45\;mg\;Kg^{-1}\;day^{-1}$</TEX>, i.p. 7 successive days. GTE concentration 1.5%, orally administered 4 days prior and 14 after TAM-intoxication as sole source...
Green tea polyphenols (GTP) is considered to have protective effects against several diseases. The hepatotoxicity of azathioprine (AZA) has been reported and was found be associated with oxidative damage. This study conducted evaluate the role GTP protect AZA-induced liver injury in rats. AZA administered i.p. a single dose (50mgkg(-1)) adult male AZA-intoxicated rats were orally (either 100mgkg(-1)day(-1) or 300mgkg(-1)day(-1), for 21 consecutive days, started 7 days prior injection)....
BackgroundLeishmaniasis is a parasitic disease affecting large number of people worldwide. In this study we carried out the molecular characterization cutaneous leishmaniasis (CL) in Al-Madinah Al-Munawarah Province, Saudi Arabia, confirming Leishmania major and tropica as prevalent species using techniques.MethodsOne hundred five patients with suspected CL were identified from four different localities Province Al-Miqat Hospital, Al-Madinah, Arabia. Thirty-four 105 selected at random for...
The present study examines the antioxidative, hypoglycemic, and hypolipidemic activities of Artocarpus heterophyllus (jack fruit) leaf extracts (JFEs). 70% ethanol (JFEE), n-butanol (JFBE), water (JFWE), chloroform (JFCE), ethyl acetate (JFEAE) were obtained. Both JFEE JFBE markedly scavenge diphenylpicrylhydrazyl radical chelate Fe +2 in vitro . A compound was isolated from identified using 1D 2D 1 H- 13 C-NMR. administration or to streptozotocin (STZ)-diabetic rats significantly reduced...
Context: Quercetin, a dietary-derived flavonoid, is ubiquitous in fruits and vegetables plays important roles human health by virtue of its antioxidant activity.Objective: This study was conducted to investigate the possible modulatory effect quercetin against hepatic lipemic-oxidative injury rats fed with high cholesterol diet (HCD), highlight underlying mechanisms such effect.Materials methods: Different groups male Sprague–Dawley were used; one group treated gavage HCD cocktail (1 mL/100...
Circulating Sex hormone binding globulin (SHBG) levels are inversely associated with insulin resistance. This study was conducted to compare maternal serum SHBG level between pregnant women normal glucose tolerance and those gestational diabetes (GDM) investigate the roll of in GDM diagnosis.This a case controlled 90 women, 45 matched controls, attending obstetrics clinic at Ohud Hospital, Madina, Saudi Arabia April 2014 March 2015. Measurement by Enzyme-linked immunosorbent assay (ELISA)...
Abstract Objectives This study aimed to explore the pharmacological properties of pinoresinol-4-O-β-D-glucopyranoside (PG), isolated from prunes. Methods In-vitro antioxidant activity was assessed using ferric reducing power (FRAP) and 2,2'-azino-bis [3-ethylbenzothiazoline-6-sulfonic acid]-diammonium salt (ABTS) assays. In-vivo hepatoprotective evaluated CCl4-induced hepatotoxicity mouse model. The antihyperglycaemic determined in vitro α-glucosidase α-amylase inhibiting vivo...
Tamoxifen citrate is an anti-estrogenic drug used for the treatment of breast cancer. It showed a degree hepatic carcinogenesis, when it long term as can decrease hexose monophosphate shunt and thereby increasing incidence oxidative stress in liver rat cells leading to injury. In this study, model injury female rats was done by intraperitoneal injection tamoxifen dose 45 mg/kg body weight 7 successive days. This produced state accompanied with noticed significant declines antioxidant enzymes...
Abstract Objectives This study was designed to evaluate the antihyperglycaemic activity of methanol leaf extract Eremophila maculata (EMM) both in vitro and vivo. Methods The assessed using differentiated 3T3-L1 adipocytes, whereas in-vivo effect evaluated streptozotocin-induced diabetic rats. Chemical profiling EMM done LC-ESI-MS techniques. Molecular modelling experiments identified compounds were performed C-Docker protocol. Key findings slightly enhanced cellular glucose uptake...