A5103967720- Plant tissue culture and regeneration
- Toxic Organic Pollutants Impact
- Pharmaceutical and Antibiotic Environmental Impacts
- Plant Genetic and Mutation Studies
- Phytochemistry and Biological Activities
- Insect and Pesticide Research
- Insect Pest Control Strategies
- Effects and risks of endocrine disrupting chemicals
- Cancer therapeutics and mechanisms
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Mercury impact and mitigation studies
- Medicinal Plants and Neuroprotection
- Immune Response and Inflammation
- Ginseng Biological Effects and Applications
- Phytochemical compounds biological activities
- Microbial Metabolites in Food Biotechnology
- Traditional and Medicinal Uses of Annonaceae
- Potato Plant Research
- 3D Printing in Biomedical Research
- Advanced Glycation End Products research
- Plant-derived Lignans Synthesis and Bioactivity
- Transgenic Plants and Applications
- Insect Utilization and Effects
- Light effects on plants
Heidelberg University
2005-2025
Due to their complex structure with several chiral centres important anticancer agents are still extracted from plants and not synthesized chemically on a commercial scale. Sustainable bioproduction of the compounds interest may be achieved by plant in vitro cultures. Undifferentiated callus suspension cultures, which can cultivated large bioreactors easily, very often fail accumulate interest, whereas shoot root cultures as well hairy roots normally produce same appropriate organs. The...
This study aims to comprehensively explore the phytoconstituents as well investigate different biological activities of Chasmanthe aethiopica (Iridaceae) for first time. Metabolic profiling leaf methanol extract C. (CAL) was carried out using HPLC-PDA-ESI-MS/MS. Twenty-nine compounds were annotated belonging various phytochemical classes including organic acids, cinnamic acid derivatives, flavonoids, isoflavonoids, and fatty acids. Myricetin-3-O-rhamnoside major compound identified. GLC/MS...
Background: The phytochemical composition, antioxidant, cytotoxic, and antimicrobial activities of a methanol extract from Glycyrrhiza glabra L. (Ge), 50% ethanol (in water) Paeonia lactiflora Pall. (Pe), 96% Eriobotrya japonica (Thunb.) Lindl. (Ue) were investigated. Methods: profiles the extracts analyzed by LC-MS/MS. Antioxidant activity was evaluated scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals reducing ferric...
Organ-on-chip platforms provide models that allow the representation of human physiological processes in cell-based miniaturized systems. Potential pre-clinical applications include drug testing and toxicity studies. Here we describe use a multi-compartment micro-fluidic chip to recapitulate hepatic vitamin D metabolism (vitamin 25-hydroxyvitamin D) renal bio-activation (25-hydroxyvitamin 1,25-dihydroxyvitamin humans. In contrast cultivation conventional tissue culture settings, on-chip...
Chronic inflammation is a hallmark of chronic wounds and inflammatory skin diseases. Due to hyperactive prolonged triggered by proinflammatory immune cells, transitioning the repair healing phase halted. T cells may exacerbate milieu secreting cytokines.
Alzheimer's disease is a rising threat for modern societies as more and people reach old age. To date, there no effective treatment this condition. In study, we investigated the potential of <i>Glycyrrhiza uralensis</i> to counteract amyloid-<i>β</i> toxicity, one key features disease. An LC-MS/MS analysis revealed glycyrrhizic acid glycosylated forms isoliquiritigenin liquiritigenin major constituents water methanol extracts <i>G. uralensis</i>. These pure compounds were tested their...
In a context of rising demand for sustainable antiaging interventions, fruit processing by-products are promising source bioactive compounds the production dietary supplements. Piquiá ( Caryocar villosum ) is native Amazonian consisting 65% nonedible shells. present study, phytochemical profile hydroalcoholic extract piquiá shells (CV) was characterized by LC-MS/MS analysis. Its antioxidant and activities were investigated using nematode Caenorhabditis elegans as an in vivo model. CV mainly...
Drosophila suzukii (Diptera: Drosophilidae), is native to southeastern Asia and invaded Europe during the past decade. It causes serious economic damage in cherries soft fruits. Control strategies rely on few insecticides with varying success. Due environmental concern, use of synthetic chemicals restricted. Therefore, research effort put into quest for alternative substances applicable chemical pest control. In laboratory assays, we tested 17 volatile plant compounds from different classes...
Background: The root of the Indonesian Pimpinella pruatjan Molk. has been mainly used as an aphrodisiac and for treatment Erectile Dysfunction (ED). Since oxidative stress favors ED, we examined antioxidant activities essential oil from P. pruatjan. Methods: chemical composition was analyzed by Gas Liquid Chromatography- Mass Spectrometry (GLC-MS). In vivo activity determined using animal model, nematode Caenorhabditis elegans, whereas antimicrobial investigated standard micro-dilution...
Acrylamide is a reactive neurotoxin with high intestinal bioavailability. Recently we have shown that under the pH regime of gut acrylamide can react proteins and this reaction reduces uptake in model. On other hand, using radioactive labeled acrylamide, Bjellaas et al. [Toxicol. Sci. 100, 374-380 (2007)] showed vivo vast majority orally administered absorbed excreted as N-acetyl-S-(3-amino-3-oxopropyl)-cysteine urine. Therefore, tested whether proteases degrade protein bound to cysteine...