Umut Safiye Şay Coşkun

ORCID: 0000-0002-4359-4799
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About
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Research Areas
  • Antibiotic Resistance in Bacteria
  • Antibiotic Use and Resistance
  • Bacterial biofilms and quorum sensing
  • Pharmaceutical and Antibiotic Environmental Impacts
  • Bacterial Identification and Susceptibility Testing
  • Viral Infections and Vectors
  • Toxoplasma gondii Research Studies
  • Vector-Borne Animal Diseases
  • Antimicrobial Resistance in Staphylococcus
  • Urinary Tract Infections Management
  • Cytomegalovirus and herpesvirus research
  • Infections and bacterial resistance
  • Mosquito-borne diseases and control
  • Enterobacteriaceae and Cronobacter Research
  • Historical Turkish Studies
  • Endodontics and Root Canal Treatments
  • Hepatitis Viruses Studies and Epidemiology
  • Rabies epidemiology and control
  • Ottoman and Turkish Studies
  • Laser Applications in Dentistry and Medicine
  • Neonatal and Maternal Infections
  • Vaccine Coverage and Hesitancy
  • Oral health in cancer treatment
  • Silymarin and Mushroom Poisoning
  • Vibrio bacteria research studies

Tokat Gaziosmanpaşa Üniversitesi
2015-2024

Adli Tıp Kurumu
2018

A toxin-antitoxin (TA) system is a set of two or more closely linked genes that are encoded as poison and corresponding antidote on protein. In typical bacterial physiology, an antitoxin binds to toxin neutralizes it, which prevents the bacterium from killing itself. We aimed determine whether P.aeruginosa Staphylococcus isolates have TA investigate there relationship between expression levels resistance antibiotics.This study included 92 P. aeruginosa 148 isolates. RelBE, higBA were...

10.4314/mmj.v30i2.3 article EN cc-by-nc-nd Malawi Medical Journal 2018-06-30

Klebsiella pneumoniae (K. pneumoniae) is a major cause of healthcare-associated infections and plays prominent role in the widespread antibiotic resistance crisis. Accurate identification carbapenemases essential to facilitate effective treatment reduce transmission K. pneumoniae. This study aimed detect carbapenemase production carbapenem-resistant strains using phenotypic genotypic methods. A total 67 obtained from various clinical samples were utilized for antimicrobial susceptibility by...

10.1590/0001-3765202420231322 article EN cc-by Anais da Academia Brasileira de Ciências 2024-01-01

Introduction: The spread of Acinetobacter baumannii, resistant to most the available antimicrobial agents, is a serious health problem. high rate carbapenem resistance among baumannii isolates considered as threat public health. In this study, we aimed determine antibiotic and related genes in carbapenem-resistant isolates.
 Methodology: Ninety six A. were included. Antimicrobial susceptibility was performed by Phoenix Automated System disk diffusion method. Carbapenem resistane...

10.3855/jidc.10556 article EN cc-by The Journal of Infection in Developing Countries 2019-01-31

The aim of this study was to determine the relationship between aggregation factor (asa1), enterococcal surface protein (esp), cytolysin (cyl), gelatinase (gelE), hyaluronidase (hyl) virulence factors and antibiotic resistance in Enterococci. VITEK 2 ID system used identify isolates their susceptibility. Virulence genes were investigated by polymerase chain reaction. Of 93 isolates, 62 (66 %) Enterococcus faecium, 31 (44 faecalis (E. faecialis ). E. faecium more resistant ampicillin,...

10.14715/cmb/2019.65.2.3 article EN Cellular and Molecular Biology 2019-02-28

Neonatal thrombocytopenia is a common hematological abnormality that occurs in 20–35% of all newborns the neonatal intensive care unit. Platelet transfusion only known treatment; however, it critical point to identify neonates who are really at risk bleeding and benefit from platelet as also has various potential harmful effects.

10.4274/balkanmedj.galenos.2020.2019.7.47 article EN Balkan Medical Journal 2020-02-11

Infectious diseases are a serious danger to public health, and plants may be potential source of novel antimicrobial agents. In this study, the antibacterial antifungal activity essential oil, hexane-chloroform, methanolic, aqueous extracts Saussurea costus (S. costus) root were evaluated against Staphylococcus aureus, Pseudomonas aeruginosa, epidermidis, Enterobacter cloacae, Enterococcus faecalis, Klebsiella pneumonia, Acinetobacter baumannii, Escherichia coli, Candida albicans. For...

10.1590/0001-3765202320230059 article EN cc-by Anais da Academia Brasileira de Ciências 2023-01-01

Toxin-antitoxin genes RelBE and HigBA are known to be involved in the formation of biofilm, which is an important virulence factor for Pseudomonas aeruginosa. The purpose this study was determine presence toxin-antitoxin exoenzyme S exotoxin A P. aeruginosa isolates whether there a relationship between as well antibiotic resistance.Identification susceptibilities determined by VITEK 2 (bioMérieux, France) automated system. genes, transcription levels were detected real-time polymerase chain...

10.1590/1806-9282.20220493 article EN Revista da Associação Médica Brasileira 2023-01-01

ÖZET Kan dolaşımı enfeksiyonları en sık karşılaşılan invazif enfeksiyonlardan biridir. Bu çalışmanın amacı kan enfeksiyonlarının ampirik tedavisinin belirlenmesinde klinisyenlere yol göstermek için kültürlerinden üreyen mikroorganizma türlerini ve antibiyotik duyarlılıklarını belirlemektir

10.5222/ankem.2018.045 article TR ANKEM Dergisi 2018-01-01

The Crimean-Congo hemorrhagic fever (CCHF) virus (CCHFV) is a tick-borne virus, whose viral RNA consists of S, L, and M segments. migrating through the ticks with animals migratory birds geographical distribution can be investigated based on genetic analysis. To better understand connection between seropositivity mortality rate, key factor could temporal spatial analysis different strains. In this study, serum samples (n = 26) were selected from CCHFV RNA-positive patients subjected to...

10.1556/030.65.2018.041 article EN Acta Microbiologica et Immunologica Hungarica 2018-09-11

Investigation of Antibiotic Resistance in Carbapenem Resistant Acinetobacter baumannii IsolatesSevere infections caused by are common patients with long-standing hospitalizations and, invasive procedures the hospital.Until recent years, carbapenems have been drugs choice for treatment A.baumannii.However, increasing resistance to has led search new options.The aim this study is determine antibiotic rates carbapenem resistant A.baumannii isolates identified various samples our hospital.In...

10.5222/ankem.2018.037 article EN ANKEM Dergisi 2018-01-01

Amaç: Çocuklarda hastanede yatışlara ve gereksiz antibiyotik kullanımına neden olmasından dolayı viral gastroenteritlerin erken tanımlanması önemlidir. Rotavirüs adenovirüs çocuklarda en sık rastlanan gastroenterit etkenleridir. Bu çalışmanın amacı akut gastroenteritli çocuk hastalardan alınan gaita örneklerinde rotavirüs sıklığının araştırılmasıdır. Gereç Yöntem: çalışmada ………Üniversitesi Tıp Fakültesi Araştırma Uygulama Hastanesi Mikrobiyoloji Laboratuvarı’na Ocak 2017- 2018 tarihleri...

10.16899/gopctd.459823 article TR Journal of Contemporary Medicine 2019-03-15

Crimean-Congo hemorrhagic fever (CCHF), an acute viral disease, has a high mortality rate among humans. Hemorrhagic propensity is caused by coagulation malfunction and increased capillary permeability brought on the resultant vascular injury. Vascular endothelial growth factor (VEGF) VEGF receptor-2, or KDR (kinase insert domain containing receptor), are effective in vasculogenesis angiogenesis. CCHF was stated to have dysfunction. This study aimed evaluate whether

10.1080/15257770.2024.2423887 article EN Nucleosides Nucleotides & Nucleic Acids 2024-11-04

Aim: This study aimed to demonstrate, through serological testing, that healthcare workers involved in forensic autopsies are at risk for HIV, hepatitis B, and C viruses, discuss the necessary precautions infection control light of literature. Materials Methods: After completion autopsy, two separate 5 ml blood samples were taken from thigh regions corpses gel tubes with yellow caps, written consent relatives deceased. The analyzed HBsAg, anti-HCV, anti-HIV 1/2 levels using Roche Cobas E601...

10.5455/nofor.2025.02.02 article EN Novel Forensic Research 2024-01-01

AbstractIntroduction Pseudomonas aeruginosa possesses a variety of virulence factors that may contribute to its pathogenicity, and relationship has been determined between antibiotic resistance biofilm. The aim this study was investigate the isolates by genotypic phenotypic methods, as well whether there is other resistance.Methods A total 80 strains were sent from various clinics included in study. Identification profile Vitek 2 (Biomerioux, France) automated system. P agar, F motility test...

10.1080/15257770.2023.2254346 article EN Nucleosides Nucleotides & Nucleic Acids 2023-09-04

Objective:  During antibiotic use some of the bacteria in our flora can be affected by used subinhibitory concentrations addition to pathogenic microorganisms. The aim this study investigate in-vitro effects on susceptibility profile of P.aeruginosa which found normal and a bacteria. Material Method:  The effective decrease with distance from disc growth-inhibition zone ends effect falls concentrations; growth starts.We accepted starting region as area which...

10.17546/msd.452046 article EN cc-by-nc Medical Science and Discovery 2018-09-20

Objective:The aim of this study was to evaluate bacterial reduction after using different irrigants, lasers and photodynamic therapy (PDT) in root canals infected by Enterococcus faecalis.Materials Methods: Seventy human maxillary incisors were used study.After endodontic preparation, sixty teeth 20 µl E. faecalis (ATCC 29212) specimens incubated for 72 hours.Groups formed according the irrigation protocol used: group 1: negative control, 2: positive 3: 10 mL 2% chlorhexidine (CHX), 4: 5%...

10.4274/meandros.08370 article EN Meandros Medical And Dental Journal 2018-12-01
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