A5087931439- Catalytic Cross-Coupling Reactions
- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Organometallic Complex Synthesis and Catalysis
- biodegradable polymer synthesis and properties
- Nanomaterials for catalytic reactions
- Model-Driven Software Engineering Techniques
- Polymer Science and PVC
- Organophosphorus compounds synthesis
- Chemical Synthesis and Analysis
- Tryptophan and brain disorders
- Supramolecular Chemistry and Complexes
- Synthetic Organic Chemistry Methods
- Cyclopropane Reaction Mechanisms
KU Leuven
2019-2025
Ligand combination of a 2-pyridone with traditional phosphines enables superior functional group tolerance in the C–H (hetero)arylation pharmaceutically relevant N -heterocyclic scaffolds.
Tuning of the hydrogenation degree and isomerization in consecutive hydrogenation-metathesis polybutadiene rubber allows excellent control over upcycled α,ω-dienes diesters.
This study presents an efficient synthesis of styrene through a one-step C–H/C–H vinyl–aryl bond formation process, aiming to mitigate the need for harsh reaction conditions and lack step efficiency two-step industrial production. In ligand accelerated palladium(II)-catalyzed arene alkenylation, tunable 2-hydroxypyridine ligands were shown enhance catalytic activity, stability, selectivity. Reaction designed obtain turnover numbers toward exceeding 3200 with Pd concentrations ranging from...
Two indoles linked by a C–C bond have recently emerged as promising scaffolds in medicinal chemistry. Their synthesis, however, involves multitude of reaction steps. So far, the direct C–H/C–H cross-coupling two similar heteroaromatics lacking directing groups remains particularly challenging. Transition metals are often added wasteful sacrificial oxidants to influence selectivity Pd-catalyzed couplings. In this work, we report on selective N-substituted without groups, driven molecular...
Chemical recycling of PVC waste materials using ZnCl 2 as a benign catalyst for solvent-based tandem dehydrochlorination–hydrogenation.
The Pd-catalyzed C-H activation of natural tryptophan residues has emerged as a promising approach for their direct synthetic modification. While using water the solvent and harnessing air oxidant is enticing, these conditions induce catalyst deactivation by promoting formation inactive Pd(0) clusters. In this work, we have studied optimized Pd-based catalytic systems via nonsteady state kinetic analysis in situ X-ray absorption spectroscopy (XAS) to overcome deactivation, which enables...
Abstract Pd(II)carboxylates have emerged as potent catalysts for the direct coupling of (hetero)aromatics, enabling a two‐fold C−H activation with various oxidants. Yet, prior research on mechanism C−H/C−H without directing group(s) has led to contrasting insights. In this work, effect acetic acid (AcOH) concentration Pd‐catalyzed benzene biphenyl is uncovered. The catalytic cycle was investigated via kinetic isotope effects, H/D exchange experiments and by assessing reactivity...
Palladium(ii)-catalyzed dehydrogenative coupling of aliphatic olefins would enable an efficient route to (conjugated) dienes, but remains scarcely investigated. Here, 2-hydroxypyridine (2-OH-pyridine) was found be effective ligand for Pd(ii) in the activation vinylic C(sp
The atom efficient transesterification of phosphate esters with catalytic base was investigated using an isopropenyl leaving group, generating acetone as the only by-product.
Abstract The C–H arylation of indoles holds the promise to shorten synthetic routes in production pharmaceuticals. However, late-stage activation reactions often rely on presence protecting groups or stoichiometric metal additives. regiospecific a highly functionalized azepino[5,3,4-cd]indole scaffold lacking directing via Pd(II) and Cu(II) co-catalysis is reported. direct coupling was demonstrated convergent synthesis rucaparib, an FDA approved anticancer drug.
The direct cross-coupling of (hetero)aromatics without prior functionalization is a promising reaction for the chemical and pharmaceutical industries, enabling conversion inexpensive feedstocks in highly step-efficient manner. However, many C-H arylations rely on high loadings Pd catalyst that preclude their use low-cost applications. In this work, we have maximized turnover rate Pd-catalyzed arylation through rational tuning ligands. Starting from computational study catalytic mechanism,...