A5102970731- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Nerve injury and regeneration
- Catalytic Cross-Coupling Reactions
- Signaling Pathways in Disease
- Synthesis and Catalytic Reactions
- Axon Guidance and Neuronal Signaling
- Viral Infectious Diseases and Gene Expression in Insects
- Neurogenesis and neuroplasticity mechanisms
Columbia University
2009-2017
Pyrazoles are important azole heteroarenes frequently found in pharmaceuticals and protein ligands, there has been a growing interest new synthetic methods for their preparation. We report the first catalytic intermolecular C-H arylation of pyrazoles, namely SEM-protected pyrazoles N-alkylpyrazoles, which lays foundation approach to synthesis complex arylated where arene rings directly attached predetermined positions heteroarene nucleus ("topologically obvious synthesis"). Through...
Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), have emerged as key regulators of brain plasticity represent disease-modifying targets for several disorders, including Alzheimer's disease major depressive disorder. Because poor pharmacokinetic properties BDNF, the interest in small-molecule TrkB agonists modulators is high. Several compounds been reported to act agonists, their increasing use various nervous system disorder models creates...
Modulation of growth factor signaling pathways in the brain represents a new experimental approach to treating neuropsychiatric disorders such as depression, anxiety, and addiction. Neurotrophins factors exert synaptic, neuronal, circuit level effects on wide temporal range, which suggests possibility rapid lasting therapeutic effects. Consequently, identification small molecules that can either enhance release or potentiate their respective will provide drug-like alternative direct...
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