A5079239944- Neuroscience and Neural Engineering
- Advanced Sensor and Energy Harvesting Materials
- EEG and Brain-Computer Interfaces
- Tactile and Sensory Interactions
- Neural dynamics and brain function
- Advanced Memory and Neural Computing
- Advanced Materials and Mechanics
- Modular Robots and Swarm Intelligence
- Epilepsy research and treatment
- Muscle activation and electromyography studies
- 3D Printing in Biomedical Research
- Electrochemical Analysis and Applications
- Transcranial Magnetic Stimulation Studies
- Nanofabrication and Lithography Techniques
Daegu Gyeongbuk Institute of Science and Technology
2017-2025
Massachusetts Institute of Technology
2023-2025
Abstract Electrocorticogram (ECoG) is an electrophysiological signal that results from the summation of neuronal activity near cortical surface. To record ECoG signals, scalp and skull are surgically opened electrodes placed on surface, either epidurally or subdurally. Owing to its improved spatiotemporal resolution quality compared with electroencephalography, it widely used diagnose treat neurological disorders in clinical settings for several decades, despite invasiveness ECoG. Recently,...
Electrocorticogram (ECoG) electrode arrays based on soft materials, such as polydimethylsiloxane (PDMS), are preferable because they can be implanted with better conformal contact and have physical properties close to biological tissues; thus, the adverse effects tissues minimal. However, realization of electrodes in micrometer scale PDMS is challenging. Previously, parylene-treated was suggested a solution proven successful acute vivo applications. In this study, PDMS-based ECoG fabricated...
Abstract Neural interfaces play an essential role to disclose neural networks and assist paralyzed patients in past decades. As the conformability longevity become vital issues for interfaces, flexible materials are increasingly engaged development of such devices. However, devices comprised polydimethylsiloxane (PDMS) is bothered because its incompatibility with silicon microfabrication technology, mainly caused by different thermal expansion coefficients between metals PDMS. Here, a...
Abstract Components in neural implants, such as the electrode array and stimulator circuit, are often fabricated discretely. This modular fabrication scheme offers flexibility during development but poses difficulties assembly, components must be compactly integrated for implantation. It is particularly difficult cases where required to have a high number of channels, retinal prostheses. paper presents parylene C‐based, double‐sided microelectrode with 294 hemispheric electrodes subretinal...
We developed a nanoscale neural probing device for in vitro sensing of activity. Single vertical platinum (Pt) nanowires were fabricated on microelectrode array by focused ion beam (FIB)-chemical vapor deposition (CVD) order to improve the spatial resolution recording and minimize damage cells. Rat neuroblasts cultured electrode array. Electrodes contact with cells detected prominent spontaneous electrical Our experiments demonstrate nanoprobes real-time detection electrophysiological...
Three-dimensional (3D) structures composed of flexible and soft materials have been in demand for implantable biomedical devices. However, the fabrication 3D using microelectromechanical system (MEMS) techniques has limitations terms scale structures. Here, a technique to selectively bond polydimethylsiloxane (PDMS) parylene-C by plasma treatment is reported, with which two-dimensional that are fabricated MEMS turned into inflation non-bonded patterns. The bonding strength mechanism were...
Abstract Neural interfaces with embedded electrical functions, such as cuff electrodes, are essential for monitoring and stimulating peripheral nerves. Still, several challenges remain electrodes because sutured devices can damage the nerve by high pressure secured contact of is hard to accomplish, which however in maintaining performance. Here, a sutureless soft‐actuated (SACE) that envelop conveniently creating bent shape controlled upon fluid injection, introduced. Moreover, injection...
This paper proposes a fabrication technique of 3-dimensional (3D) soft and flexible devices with embedded crack-free metal patterns. After the selective bonding between PDMS parylene-C, additional MEMS techniques such as patterning conductive lines pads can be processed on 2D plane before transformation into 3D structure. Moreover, processes have been optimized to achieve patterns, because microcracks in patterns could affect electrical connections life-time devices. Based advantageous...
This paper describes an intrafascicular neural interface for peripheral nerve implantation. The flexible penetrating microelectrode array with varying lengths (vl-FPMA), interconnection cable, wireless recording and stimulator modules were designed fabricated to detect signals from the nerves or stimulate them. vl-FPMA consisted of silicon needles polydimethylsiloxane (PDMS) platform supporting needles. length electrode varied 600 1000 μm. cable was as parylene-metal-parylene sandwiched...
3-dimensional (3D) structures composed of flexible and soft materials have been in demand for bio-integrated devices. However, the fabrication 3D using micro electro mechanical systems (MEMS) techniques has limitations terms commonly used inorganic microscale resulted structures. Here, we developed a novel technique to selectively bond polydimethylsiloxane (PDMS) parylene C by plasma treatment, with which 2D fabricated conventional MEMS are transformed into inflation non-bonded patterns. We...