A5021346119- Osteoarthritis Treatment and Mechanisms
- RNA Interference and Gene Delivery
- Bone health and treatments
- Fibroblast Growth Factor Research
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Knee injuries and reconstruction techniques
- Proteoglycans and glycosaminoglycans research
- NF-κB Signaling Pathways
- Chemokine receptors and signaling
- Silk-based biomaterials and applications
- Cell Adhesion Molecules Research
- Metabolism, Diabetes, and Cancer
Université Paris Cité
2022-2024
Inserm
2021-2024
Sorbonne Paris Cité
2024
Bioscar
2022-2023
Articular cartilage has low regenerative capacity despite permanent stress. Irreversible lesions characterize osteoarthritis (OA); this is not followed by tissue repair. Lin28a, an RNA binding protein, detected in damaged humans and mice. We investigated the role of LIN28a physiology osteoarthritis. Lin28a-inducible conditional deletion up-regulated Mmp13 intact mice exacerbated destruction OA Lin28a-specific overexpression protected against breakdown, stimulated chondrocyte proliferation...