A5022625994- Calpain Protease Function and Regulation
- Autophagy in Disease and Therapy
- Bone and Dental Protein Studies
- Tumors and Oncological Cases
- Nitric Oxide and Endothelin Effects
- Bone Tissue Engineering Materials
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Osteoarthritis Treatment and Mechanisms
- Cancer, Hypoxia, and Metabolism
- Genetic Syndromes and Imprinting
- Renin-Angiotensin System Studies
- Vitamin K Research Studies
- Dental Implant Techniques and Outcomes
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Toxoplasma gondii Research Studies
- Forensic Entomology and Diptera Studies
- Metabolomics and Mass Spectrometry Studies
- Bone Metabolism and Diseases
- Bone health and treatments
- Mesenchymal stem cell research
- Cell Adhesion Molecules Research
- Periodontal Regeneration and Treatments
- Bone fractures and treatments
Université Paris Cité
2018-2024
Laboratory Orofacial Pathologies, Imaging and Biotherapies
2021-2024
Sorbonne Paris Cité
2018-2024
Inserm
2018-2022
Bioscar
2017-2022
Délégation Paris 7
2018
Articular cartilage has low regenerative capacity despite permanent stress. Irreversible lesions characterize osteoarthritis (OA); this is not followed by tissue repair. Lin28a, an RNA binding protein, detected in damaged humans and mice. We investigated the role of LIN28a physiology osteoarthritis. Lin28a-inducible conditional deletion up-regulated Mmp13 intact mice exacerbated destruction OA Lin28a-specific overexpression protected against breakdown, stimulated chondrocyte proliferation...
Sarcomas are still unsolved therapeutic challenges. Cancer stem cells believed to contribute sarcoma development, but lack of specific markers prevents their characterization and targeting. Here, we show that calpain-6 expression is associated with cancer cell features. In mouse models bone sarcoma, calpain-6-expressing have unique tumor-initiating metastatic capacities. Calpain-6 levels especially high in tumors been successfully propagated establish patient-derived xenografts. We found...
Abstract Within the cardiovascular system, protein vasorin (Vasn) is predominantly expressed by vascular smooth muscle cells (VSMCs) in coronary arteries and aorta. Vasn knockout ( −/− ) mice die within 3 weeks of birth. In present study, we investigated role expression on function. We used inducible CRE‐ERT KO SMMHC‐CRE‐ERT2 , which respectively all or SMCs only are targeted) to analyze consequences total selective loss Furthermore, vivo effects were vitro using human VSMCs. The death 21...
Abstract Parental imprinting is an epigenetic process leading to monoallelic expression of certain genes depending on their parental origin. Imprinting diseases are characterized by growth and metabolic issues starting from birth adulthood. They mainly due methylation defects in control region that drive the abnormal imprinted genes. We currently lack relevant animal or cellular models unravel pathophysiology failure these diseases. aimed characterize regions dental pulp stem cells during...
Abstract Bone diseases are increasing with aging populations and it is important to identify clues develop innovative treatments. Vasn , which encodes vasorin (Vasn), a transmembrane protein involved in the pathophysiology of several organs, expressed during development intramembranous endochondral ossification zones. Here, we studied impact deletion on osteoblast osteoclast dialog through cell Coculture model. In addition, explored bone phenotype KO mice, either constitutive or...
Scaffolds associated with different types of mesenchymal stromal stem cells (MSC) are extensively studied for the development novel therapies large bone defects. Moreover, monoclonal antibodies have been recently introduced treatment cancer-associated loss and other skeletal pathologies. In particular, against sclerostin, a key player in remodeling regulation, demonstrated real benefit treating osteoporosis but their contribution to tissue-engineering remains uncharted. Here, we show that...
The post-mortem interval (PMI) is the time elapsed between death of an individual and its forensic examination. It a crucial information for judicial authorities, but current techniques still cannot establish precise interval. Novel approaches are therefore required. Recently, gingival tissue has emerged as interesting analysis thanks to protection offered by lips this tissue, limiting influence environmental factors. also easily accessible, sampling minimally invasive even in presence rigor...
Scaffolds associated with different types of mesenchymal stromal stem cells (MSC) are extensively studied for the development novel therapies large bone defects. Moreover, monoclonal antibodies have been recently introduced treatment cancer-associated loss and other skeletal pathologies. In particular, against sclerostin, a key player in remodeling regulation, demonstrated real benefit treating osteoporosis but their contribution to tissue-engineering remains uncharted. Here, we show that...