A5075017938- Bone and Dental Protein Studies
- Parathyroid Disorders and Treatments
- dental development and anomalies
- Dental Health and Care Utilization
- Oral microbiology and periodontitis research
- Vitamin D Research Studies
- Digestive system and related health
- Bone health and treatments
- Dental Erosion and Treatment
- Oral and Maxillofacial Pathology
- Dental Research and COVID-19
- Oral and gingival health research
- Simulation-Based Education in Healthcare
- Congenital heart defects research
- Renin-Angiotensin System Studies
- Periodontal Regeneration and Treatments
- Genomics and Rare Diseases
- Therapeutic Uses of Natural Elements
- Vitamin K Research Studies
- Innovations in Medical Education
- Endodontics and Root Canal Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Oral and Craniofacial Lesions
- Caveolin-1 and cellular processes
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Assistance Publique – Hôpitaux de Paris
2008-2024
Sorbonne Paris Cité
2012-2024
Université Paris Cité
2012-2024
Sorbonne Université
2017-2024
Hôpitaux Universitaires Henri-Mondor
2020-2024
Hôpital Cochin
2023-2024
Inserm
2008-2024
Laboratory Orofacial Pathologies, Imaging and Biotherapies
2017-2018
Hôpital Charles-Foix
2018
Délégation Paris 5
2008-2017
In humans, the SOST gene encodes sclerostin, an inhibitor of bone growth and remodeling, which also negatively regulates repair process. Sclerostin has been implicated in tooth formation, but its potential role pulp healing remains unknown. The aim this study was to explore sclerostin reparative dentinogenesis using Sost knockout mice (Sost–/–). pulps first maxillary molars were mechanically exposed 3-mo-old Sost–/– wild-type (WT) (n = 14 per group), capped with mineral trioxide aggregate...
Treatment of X-linked hypophosphatemic rickets improves bone mineralization and deformities, but its effect on skeletal growth is highly variable.Genetic variants in the promoter region vitamin D receptor (VDR) gene may explain response to treatment because this mediates action.We studied VDR haplotype structure a large cohort 91 patients with including 62 receiving 1alpha-hydroxyvitamin D3 derivatives phosphates from early childhood on.Treatment improved deformities final height, 39%...
Familial hypophosphatemic rickets is transmitted in most cases as an X-linked dominant trait and results from the mutation of PHEX gene predominantly expressed osteoblast odontoblast. Patients with have been reported to display important dentin defects. Our purpose was explore structure, composition distribution noncollagenous proteins (NCPs) dentin. We collected teeth 10 patients whose mineralization occurred either a environment or corrected phosphate vitamin environment. Teeth were...
Abstract BACKGROUND Objective Structured Clinical Examinations (OSCEs) are amongst the most anxiety‐provoking competency assessment methods. An online serious game (OSCEGame) was developed and implemented within OSCE curriculum. This study aimed to evaluate usefulness of this on preparedness reducing OSCE‐related stress. METHODS A designed help dental students train for OSCEs. Two courses (4 stations each) were according year undergraduate training th 5 year), based 6 pre‐existing...
Abstract Within the cardiovascular system, protein vasorin (Vasn) is predominantly expressed by vascular smooth muscle cells (VSMCs) in coronary arteries and aorta. Vasn knockout ( −/− ) mice die within 3 weeks of birth. In present study, we investigated role expression on function. We used inducible CRE‐ERT KO SMMHC‐CRE‐ERT2 , which respectively all or SMCs only are targeted) to analyze consequences total selective loss Furthermore, vivo effects were vitro using human VSMCs. The death 21...
The importance of phosphate (Pi) as an essential component hydroxyapatite crystals suggests a key role for membrane proteins controlling Pi uptake during mineralization in the tooth. To clarify involvement currently known transporters (Slc17a1, Slc34a1, Slc34a2, Slc34a3, Slc20a1, Slc20a2, and Xpr1) tooth development mineralization, we determined their spatiotemporal expression murine germs from embryonic day 14.5 to postnatal 15 human dental samples Nolla stages 6 9. Using real-time...
Abstract Bone diseases are increasing with aging populations and it is important to identify clues develop innovative treatments. Vasn , which encodes vasorin (Vasn), a transmembrane protein involved in the pathophysiology of several organs, expressed during development intramembranous endochondral ossification zones. Here, we studied impact deletion on osteoblast osteoclast dialog through cell Coculture model. In addition, explored bone phenotype KO mice, either constitutive or...
L’odontogenèse résulte d’évènements reflétant de multiples processus impliqués dans le développement : crêtes neurales, interactions épithélio-mésenchymateuses, minéralisation. Les anomalies dentaires sont donc d’excellents marqueurs l’impact mutations gènes qui affectent différents systèmes biologiques, tels que métabolisme minéral, l’os, rein, la peau ou système nerveux. Dans cette revue, nous présentons façon synthétique les plusieurs maladies rares au travers défauts des dents...
Abstract Background During the 2021–2022 academic year, an integrated curriculum in gerodontology, including interactive teaching activities, has been proposed from second to fifth year of initial training. This pilot study aimed evaluate educational impact online mandatory activities three quizzes and a serious game (SG) offered fourth‐year students addition passive courses gerodontology. Materials methods Students’ participation SG their subsequent satisfaction were evaluated. performance...
Amelogenesis imperfecta (AI) represents rare tooth anomalies that affect the quality and/or quantity of enamel. Clinical phenotypes display a wide spectrum, ranging from mild color changes to severe structural alterations with daily pain. However, all life because mechanical, psychological, esthetic, social repercussions. Several gene mutations have been linked AI as nonsyndromic (isolated) phenotype or wider syndrome. This case report aimed present family dental structure followed up in...