A5069833139- Bacteriophages and microbial interactions
- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- Animal Disease Management and Epidemiology
- Vector-borne infectious diseases
- Viral Infections and Vectors
- Cytomegalovirus and herpesvirus research
- Advanced biosensing and bioanalysis techniques
- Viral gastroenteritis research and epidemiology
- Herpesvirus Infections and Treatments
- Nanocluster Synthesis and Applications
- Genomics and Phylogenetic Studies
- Virology and Viral Diseases
- Chemical Synthesis and Analysis
- Viral Infectious Diseases and Gene Expression in Insects
- Gold and Silver Nanoparticles Synthesis and Applications
- Monoclonal and Polyclonal Antibodies Research
- Bartonella species infections research
- Toxoplasma gondii Research Studies
- Plant Virus Research Studies
Yanbian University
2025
University of Alberta
2016-2024
Shanghai Jiao Tong University
2024
Alberta Glycomics Centre
2016-2020
The photoluminescent properties of atomically precise metal nanoclusters (MCs) have garnered significant attention in the fields chemical sensing and biological imaging. However, limited brightness single-component hinders their practical applications, conventional ligand engineering approaches proven insufficient enhancing emission efficiency MCs. Here, we present a DNA framework-guided strategy to prepare highly luminescent cluster nanoaggregates. Our approach involves an amphiphilic...
Abstract Background Neospora caninum is an intracellular parasitic protozoon that can infect pregnant animals and cause symptoms such as miscarriage, stillbirth mummified fetuses. It one of the main causes miscarriage in bovines. Apical membrane antigen (AMA) dense granule protein (GRA) are two major antigenic proteins N. caninum. Methods In this study, NcGRA9 recombinant subunit vaccine Ad5-NcAMA1 adenovirus were prepared used to immunize C57BL/6 mice Yanbian yellow cattle. Results IgG,...
Introduction Ticks are important ectoparasites of livestock. and tick-borne diseases (TBDs) cause losses to the animal husbandry industry also present a major hidden danger public health safety. However, tick species prevalence TBDs in border regions China, Russia, North Korea remain unknown. The purpose this study was identify pathogens endemic these regions. Methods Morphological molecular identification ticks performed by microscopy polymerase chain reaction (PCR), distribution species,...
Significance The chloroviruses are unusual because they predicted to encode most, if not all, of the machinery synthesize glycans attached their major capsid proteins. Here we show that two virus-encoded proteins A064R and A061L functionally active. has three domains: first GTs third domain is a methyltransferase. methyltransferase activity. action these enzymes produce fragment 2,3-di-O-methyl-α- l -Rha-(1→2)-β- -Rha, which part complex N-linked glycan virus protein. 2 member new GT family....
Abstract Chlorella viruses produce N ‐linked glycoproteins with carbohydrate moieties that differ in structure from all other glycans. In addition, unlike most viruses, these organisms do not hijack the biosynthetic machinery of host to make glycocoproteins; instead, they their own carbohydrate‐processing enzymes. A better understanding function and assembly fascinating structurally‐unprecedented glycans requires access probe molecules. This work describes first synthesis a chlorella virus...
Chloroviruses produce a capsid protein containing N-linked glycans differing in structure from those found all other organisms. These species feature core "hyper-branched" fucose residue which every hydroxyl group is glycosylated. We describe the synthesis of nonasaccharide Paramecium bursaria chlorella virus 1, one most complex chlorovirus N-glycans reported, using "counterclockwise" strategy involving sequential addition trisaccharide, disaccharide, and monosaccharide motifs to...
Protein A075L is a β-xylosyltransferase that participates in producing the core of N-glycans found VP54, major viral capsid protein Paramecium bursaria chlorella virus-1 (PBCV-1). In this study, we present an X-ray crystallographic analysis apo form A075L, along with its complexes sugar donor and trisaccharide acceptor. The structure shows typical GT-B folding, two Rossmann-like fold domains, which acceptor substrate binds to N-terminal region, nucleotide-sugar C-terminal region. We propose...
Abstract A route for the synthesis of glycuronamides via intermediacy 6‐ S ‐tolyl‐substituted glycosides and uronic acid thioesters, is reported. The route, which compatible with a variety carbohydrate residues protecting groups, was used to synthesize repeating unit E. coli K54 capsular polysaccharide.