A5026722760- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Dermatology and Skin Diseases
- Cell Adhesion Molecules Research
- Antibiotic Resistance in Bacteria
- Collagen: Extraction and Characterization
- Genetic and rare skin diseases.
- Streptococcal Infections and Treatments
- Autoimmune Bullous Skin Diseases
- Dermatological and Skeletal Disorders
- Cancer Cells and Metastasis
- Neuroscience and Neural Engineering
- Nail Diseases and Treatments
- Sepsis Diagnosis and Treatment
- Psoriasis: Treatment and Pathogenesis
- Asthma and respiratory diseases
- Urticaria and Related Conditions
- Chronic Lymphocytic Leukemia Research
- Gastric Cancer Management and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Dermatological and COVID-19 studies
- Microtubule and mitosis dynamics
- Peptidase Inhibition and Analysis
- Protein Kinase Regulation and GTPase Signaling
Iowa State University
2012-2025
University Hospital of Basel
2025
Universitätsklinikum Erlangen
1998-2024
Wehrwissenschaftliches Institut für Werk- und Betriebsstoffe
2013-2021
Friedrich-Alexander-Universität Erlangen-Nürnberg
1993-2019
Institut thématique Génétique, génomique et bioinformatique
2018
Asklepios Klinik Altona
2008-2018
University Hospital in Halle
2018
Ames National Laboratory
2016
Martin Luther University Halle-Wittenberg
2012
Focal adhesions (FAs) are mechanosensitive adhesion and signaling complexes that grow change composition in response to myosin II–mediated cytoskeletal tension a process known as FA maturation. To understand tension-mediated maturation, we sought identify proteins recruited FAs II–dependent manner examine the mechanism for their II–sensitive association. We find recruitment of both adapter protein vinculin tyrosine kinase (FAK) II extracellular matrix (ECM) stiffness dependent. Myosin...
Background Most prognostic indices for severely injured patients are based on anatomical findings and the vital signs. The posttraumatic organ failure, however, is thought to be triggered by initial inflammatory response. objective of this study was evaluate correlation between early activation inflammation rate failure death. Methods Sixty-six with multiple injuries (Injury Severity Score > 18, age 18-70 years, admission within 6 hours after accident, survival 48 hours) were included in...
The pathogenesis of cancer is often driven by local invasion and metastasis. Recently, mechanical properties the tumor microenvironment have been identified as potent regulators metastasis, while matrix metalloproteinases (MMPs) are classically known significant enhancers cell migration invasion. Here we able to sensitively measure MMP activity changes in response specific extracellular (ECM) environments contractility states. Cells a pancreatic line, Panc-1, up-regulate activities between...
Migration of eukaryotic cells toward a chemoattractant often relies on their ability to distinguish receptor-mediated signaling at different subcellular locations, phenomenon known as spatial sensing. A prominent example that is seen during wound healing fibroblast migration in platelet-derived growth factor (PDGF) gradients. As the well-characterized chemotactic Dictyostelium discoideum and neutrophils, cytoskeleton via phosphoinositide 3-kinase pathway fibroblasts spatially polarized by...
Directed cell migration is essential in biological processes like embryonic development, wound healing and cancer metastasis driven by a variety of directional cues, including aligned fibrils the extracellular matrix (ECM), phenomenon known as contact guidance. How different cells respond to how external factors ECM stiffness internal regulators formins Arp2/3 control guidance across type unknown. In this study, unique system assemble collagen on mica transfer them onto substrates with...
Background The majority of functional ischemia tests in patients with suspected chronic coronary syndromes (CCS) yield normal results. Implementing gatekeepers for patient preselection, such as pretest probability (PTP) and/or artery calcium score (CACS), could reduce the number scan results, radiation exposure and costs. However, efficacy safety these approaches remain unclear. Methods Three diagnostic algorithms based on PTP, summarised 2019 European Society Cardiology (ESC) CCS...
Directed cell migration is mediated by cycles of protrusion, adhesion, traction generation on the extracellular matrix and retraction. However, how events after protrusion are timed, what dictates their temporal order completely unknown. We used acute epidermal growth factor (EGF) stimulation keratinocytes to initiate cycle study mechanism timing generation, de-adhesion. Using microscopic biochemical assays, we surprisingly found that at approximately 2 min EGF activation myosin-II, adhesion...
An Escherichia coli strain resistant to a broad spectrum of beta-lactams, including cephamycins, was isolated from patient suffering urinary tract infection. A resistance plasmid (pMVP-7) transferred the clinical isolate an recipient. Both strains produce cefoxitin-hydrolyzing beta-lactamase focusing at pI 6.7. The phenotype similar that Klebsiella pneumoniae producing cephamycinase FOX-1, so primers were selected FOX-1 sequence amplify bla gene transconjugant. PCR product obtained...
Journal Article Hepato‐erythropoietic porphyria presenting as scleroderma and acrosclerosis in a sibling pair Get access N. SIMON, SIMON Department of Dermatology Sexual Pathology, University Medical School, Szeged, Hungary Search for other works by this author on: Oxford Academic Google Scholar GY. BERKÓ, BERKÓ I. SCHNEIDER British Dermatology, Volume 96, Issue 6, 1 June 1977, Pages 663–668, https://doi.org/10.1111/j.1365-2133.1977.tb05212.x Published: 01 1977
Invasion of cancer cells into the surrounding tissue is an important step during progression and driven by cell migration. Cell migration can be random, but often it directed various cues such as aligned fibers composed extracellular matrix (ECM), a process called contact guidance. During guidance, bias along long axis fibers. These ECM are commonly type I collagen, abundant structural protein around tumors. In this paper, we epitaxially grew several different patterns organized collagen on...
Abstract Background The increase in the incidence of atopic dermatitis (AD) developed countries has been related to familiar and environmental factors. This survey was undertaken investigate family background, birthweight home environment children suffering from AD order point out possible factors that provoke development disease. Methods study uses data collected by means self‐administered questionnaires discusse s 461 cases (age 0–12) with active skin signs AD. control group comprised 343...
Cell migration plays an essential role in many biological processes, such as cancer metastasis, wound healing and immune response. is mediated through protrusion focal adhesion (FA) assembly, maturation disassembly. Epidermal growth factor (EGF) known to enhance rate cell types; however it not how FA maturation, dynamics are regulated during EGF-induced migration. Here we use total internal reflection fluorescence (TIRF) microscopy image analysis quantify properties under different doses of...
As regulators of multifunctional metalloproteinases including MMP, ADAM and ADAMTS families, tissue inhibitors (TIMPs) play a pivotal role in extracellular matrix remodeling, which is involved wide variety physiological processes. Since abnormal metalloproteinase activities are related to numerous diseases such as arthritis, cancer, atherosclerosis, neurological disorders, TIMPs their engineered mutants hold therapeutic potential thus have been extensively studied. Traditional productions...