A5003901553- Heavy Metal Exposure and Toxicity
- Tryptophan and brain disorders
- Medicinal Plants and Neuroprotection
- Circadian rhythm and melatonin
- Trace Elements in Health
- Stress Responses and Cortisol
- Aluminum toxicity and tolerance in plants and animals
- Biochemical effects in animals
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Weed Control and Herbicide Applications
- Pesticide and Herbicide Environmental Studies
- Birth, Development, and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Curcumin's Biomedical Applications
- Sleep and Wakefulness Research
- Pesticide Exposure and Toxicity
- Impact of Technology on Adolescents
- Child Development and Digital Technology
- Diet and metabolism studies
- Anesthesia and Neurotoxicity Research
- Memory and Neural Mechanisms
- Educational Methods and Impacts
- Pharmacological Effects of Medicinal Plants
- Diet, Metabolism, and Disease
Université Ibn-Tofail
2018-2025
E arly life stress (ELS) such as parental loss, low socioeconomic status, childhood maltreatment, and malnutrition or viral infection
Nickel (Ni) toxicity has been reported to produce biochemical and behavioral dysfunction. The present study was undertaken examine whether Ni chronic administration can induce alterations of affective cognitive behavior oxidative stress in male female rats. Twenty-four rats, for each gender, divided into control three test groups (n = 6), were injected intraperitoneally with saline (0.9% NaCl) or NiCl2 (0.25 mg/kg, 0.5 mg/kg 1 mg/kg) 8 weeks. After treatment period, animals tested the...
Aluminum (Al) is a well-established neurotoxicant, affecting various regions of the brain and causing many neuropathological neurobehavioral abnormalities as well oxidative stress (OS).Conversely, melatonin (MEL) has been considered an antidepressant, anxiolytic substance protects neurons from OS.The present study was designed to evaluate neuroprotection effect MEL against Al neurotoxicity OS in male Wistar rats.Rats received intraperitoneal and/or single intrahippocampal injection NaCl, or...
Fructose high diet constitutes a risk factor for metabolic disorders (Tovoli et al., 2023), in addition, it negatively affects the structure and functioning of nervous system mainly brain.Neuropsychiatric symptoms are common obesity significantly influence social quality life people with Research
Copper (Cu) is a heavy metal with the ability to induce, at high levels, neurobehavioral alterations, and oxidative stress (OS). On other hand, melatonin (Mel) neurohormone that protects neurons from OS has modulatory effect on several behavioral processes. The present experiment was aimed examine of Mel treatment Cu-induced anxiety-like, depression-like behaviors, memory impairment, in hippocampus. Herein, adult Wistar rats both genders received daily (4 mg/kg) thirty minutes before CuCl2...
The main objective of this work is to study the effect chronic administration cadmium (Cd) on level depression-like, anxiety-like, memory state and oxidative stress in male female Wistar rats. For purpose, was conducted with 24 rats for each gender. Four groups were constituted: (Group 1: Control): received saline solution NaCl (0.9%), 2: Cd-0.25; Group 3: Cd-0.5; 4: Cd-1): daily 0.25 mg/kg, 0.5 mg/kg 1 Cd respectively during 8 weeks. After treatment period, animals tested open-field,...
In recent years, Salvia officinalis has been a subject of intensive studies to document its traditional use and find new biological effects.Numerous have carried out in this contest most them were interested extract' effects not many explored the activities essential oil, especially ones related central nervous system.The Purpose study is investigate acute toxicity salvia oil female Wistar rats, explore antidepressant-like anxiolytic-like memory enhancing safe dose oil.In experiment, was...
This research aimed to investigate the possible anti-amnesic effects of a combined therapy involving melatonin and H2S in rat model displaying Depressive-Like Behaviors caused by Chronic Unpredictable Mild Stress (CUMS). Our study aims assess efficacy this treatment mitigating oxidative stress neuroinflammation striatum hippocampus. Furthermore, we seek its ability restore BDNF levels within specific model. The rats underwent 4-week CUMS protocol were administered sodium hydrosulfide (a...
In this study, we investigated the effect of chronic exposure low doses Aluminum on affective and cognitive disorders in male female rats. Twenty-five rats for each gender are used treatment carried out 8 weeks. Animals received distilled water control or an intraperitoneal injection different Aluminum: 0.125, 0.25, 0.5 1 mg/kg. Behavioral performance is measured various tests mainly Open Field, Elevated Plus Maze, Force Swimming Test, Morris Water Y-maze Object Recognition Test. Al exerts...
Aluminum (Al) is one of the more widespread metals in environment and most abundant known for its neurotoxicity both humans animals could be a potential factor inducing behavioral changes, oxidative stress (OS) loss synapses neurons hippocampal areas. The main objective this study to determine impact single intracerebral injection AlCl3 at different doses on right hippocampus affective cognitive behaviors, levels OS morphological changes male Wistar rats. Rats were treated with...
The present work is carried out to explore the neuroprotective potential of Melatonin(Mel), on Ni-induced neurobehavioral, biochemical and histological alterations in male female rats. rats were intraperitoneally administered by nickel chloride (NiCl2, 1 mg/kg) Mel (4 for 60 days. A neurobehavioral assessment was performed. Biochemical determinations oxidative stress (OS) levels, analysis hippocampal tissues also Results showed that Nickel (Ni) treatment increased anxiety-like...
The study focuses on the intricate relationship between excessive smartphone use, insomnia, and academic performance among middle school adolescents in Kenitra, Morocco. It also seeks to understand how gender type influence these variables what implications this may have for well-being of adolescents. Data were collected through specific questionnaires assessing usage (SAS), levels insomnia (measured by ISI score), (S2 grades) from various schools, both public private. These data then...
Manganese (Mn) is present everywhere: in rocks, soil, water, food, and various forms.Our bodies utilize it to contribute energy metabolism perform many other functions, but prolonged exposure can lead toxicity the organism.This study aimed evaluate effects of chronic Mn, specifically its impact on general condition male Wistar rats, by recording all clinical symptoms associated with this intoxication.Different doses ranging from lowest highest (6 mg/kg, 25 30 40 mg/kg i.p.) were administered...
Teaching has been identified as one of a highly stressful jobs. As known, this job is linked to development neuropsychiatric. However, there little background about the assessment these problems among Moroccan teachers. This study aims measure prevalence stress, anxiety and depression 150 newly recruited contractual primary teachers in KHEMISSET city using three international scales. The perceived stress scale (PSS) for hospital (HADS) Mini International Neuropsychiatric Interview (MINI)...