Recent developments in sequencing technology have facilitated widespread investigations of genomic variants, including continuous stretches homozygous regions. For cattle, a large proportion these runs homozygosity (ROH) are likely the result inbreeding due to accumulation elite alleles from long-term selective breeding programs. In present study, ROH were characterized four cattle breeds with whole genome sequence data and distribution predicted functional variants was detected regions...

Most existing tools for constructing genetic prediction models begin with the assumption that all variants contribute equally towards phenotype. However, this represents a suboptimal model how heritability is distributed across genome. Therefore, we develop allow user to specify model. We compare individual-level data using 14 UK Biobank phenotypes; our new tool LDAK-Bolt-Predict outperforms Lasso, BLUP, Bolt-LMM and BayesR phenotypes. summary statistic 225 LDAK-BayesR-SS lassosum, sBLUP,...

Abstract Reducing methane emissions from livestock production is of great importance for the sustainable management Earth’s environment. Rumen microbiota play an important role in producing biogenic methane. However, knowledge how host genetics influences variation ruminal and their joint effects on emission limited. We analyzed data 750 dairy cows, using a Bayesian model to simultaneously assess impact emission. estimated that explained 24% 7%, respectively, levels. In this model, one...

ABSTRACT Most existing tools for constructing genetic prediction models begin with the assumption that all variants contribute equally towards phenotype. However, this represents a suboptimal model how heritability is distributed across genome. Therefore, we develop allow user to specify model. We compare individual-level data using 14 UK Biobank phenotypes; our new tool LDAK-Bolt-Predict outperforms Lasso, BLUP, Bolt-LMM and BayesR phenotypes. summary statistic 225 LDAK-BayesR-SS lassosum,...

Abstract Domestic animals provide a robust model system to understand complex evolutionary processes and their genomic consequences. Zhang et al. use full re-sequenced genomes of modern dairy cattle identify haplotypes in the an admixed.... can serve as systems adaptive introgression signatures. In part, usefulness is due well-known histories. Different breeding strategies such artificial selection have generated numerous desirable phenotypes superior performance domestic animals. The Danish...

Whole-genome sequencing and imputation methodologies have enabled the study of effects genomic variants with low to very minor allele frequency (MAF) on variation in complex traits. Our objective was estimate proportion variance explained by imputed sequence classified according their MAF compared pedigree-based additive genetic relationship matrix for 17 traits Nordic Holstein dairy cattle. Imputed were grouped into seven classes (0.001–0.01, 0.01–0.05, 0.05–0.1, 0.1–0.2, 0.2–0.3, 0.3–0.4...

Abstract Dyslipidemia is the primary cause of cardiovascular disease, which a serious human health problem in large parts world. Therefore, it important to understand genetic and molecular mechanisms that regulate blood levels cholesterol other lipids. Discovery elements regulatory machinery often based on genome wide associations studies (GWAS) focused end-point phenotypes such as total level or disease diagnosis. In present study, we add endophenotypes, serum intermediate metabolites...

Availability of whole-genome sequence data for a large number cattle and efficient imputation methodologies open new opportunity to include rare low-frequency variants (RLFV) in genomic prediction dairy cattle. The objective this study was examine the impact including RLFV that are within genes selected from variants, on reliability fertility, health longevity cattle.All genic with minor allele frequency lower than 0.05 were extracted imputed subsets created using different strategies. These...

There is growing interest in the role of rare variants variation complex traits due to increasing evidence that are associated with quantitative traits. However, association methods commonly used for mapping common not effective map variants. Besides, livestock populations have large half-sib families and occurrence may be confounded family structure, which makes it difficult disentangle their effects from mean effects. We compared power applied human genetics cattle using whole-genome...

Complex evolutionary processes, such as positive selection and introgression can be characterized by in-depth assessment of sequence variation on a whole-genome scale. Here, we demonstrate the combined effects adaptive genomes, resulting in observed hotspots runs homozygosity (ROH) haplotypes modern bovine (Bos taurus) genome. We first confirm that these ROH hotspot are results selection. The under selection, including genes biological interest, PLAG1, KIT, CYP19A1 TSHB, were known to...

分析, 探索了抗生素对其大核基因组中核糖体小亚基 RNA 基因(SSU rDNA)序列多样性的影响.结果表明, 与对照组相比, 3 个土霉素处理组(1, 10 和 20 µg/mL)中纤毛虫的自然增长 率随土霉素浓度升高显著降低, 细胞大小则呈增大趋势.SSU rDNA 序列单倍型多样性、核苷酸多样性和 GC

Abstract The Chinese mitten crab Eriocheir sinensis is an important aquaculture species in China. Recently, hepatopancreatic albinism and necrosis have become issues that affect the farming industry. In this study, live samples were collected from a local farm, which further classified into four groups based on their colour, i.e., I, yellow; II, yellow-white; III, white; and, IV, shrunken necrotic. compared with respect to hepatosomatic index (HSI), hepatopancreas histology, as well...

This study evaluated the feasibility of domesticating bioflocs with activated sludge as inoculum at high salinity. Using method salinity (0.2-4.0%) gradient ascent from o.2 to 4.0% explore its effects on removal harmful nitrogen aquaculture water, morphology and performance biological flocs. From pespective purification flocs, under condition 2.5-4.0%, there were sharp drop COD rate 63.9% 3.7%, obvious accumulation ammonia nitrite except nitrate which could be maintained 0.5 mg /L or less,....