Hepatic encephalopathy (HE) is a syndrome that arises from acute or chronic liver failure. This study was devised to assess the impact of combination boswellic acid (BA) and low doses gamma radiation (LDR) on thioacetamide (TAA)-induced HE in an animal model. The effect daily BA treatment (175 mg/kg body weight, for four weeks) and/or fractionated low-dose γ-radiation (LDR; 0.25 Gy, twice total dose 0.5 Gy) evaluated against TAA (200 mg/kg, intraperitoneal) twice-weekly weeks induce damage...

Liver injury due to ionizing radiation exposure either accidental or after radiotherapy treatment, may lead many alterations in proteins expression related inflammation apoptosis. Our study investigated the curative effect of Mangosteen (MGS) extract (fruit rind) against (IR) induced liver damage.Hepatotoxicity was Wister rats by an acute single dose (6 Gy) IR while MGS given orally (500 mg/kg bwt) and administered daily for 30 days irradiation.MGS treatment has significantly attenuated...

Abstract Background Oral insulin administration has recently become one of the most exciting research subjects. Different approaches have been carried out to get an effective oral delivery system using nanotechnology. The development a that overcomes difficulties administration, achieving high stability and minimal side effects, is still urgent need. Therefore, this study considered efforts design new prospective drug nano-composite (silica-coated chitosan-dextran sulfate nanoparticles)....

Abstract Iron oxide nanoparticles (IONPs) possess many utilizable physical and chemical properties have an acceptable level of biocompatibility. Therefore, they are extensively used in different medical applications. Hence, the challenge is to modify surfaces prepared iron nanoformulations with a biocompatible coat enhance their biosafety. In this study, formulations IONPs capping agents (citrate [Cit‐IONPs], curcumin [Cur‐IONPs], chitosan [CS‐IONPs]) were characterized using various...

This study was carried out during 2017 and 2018 seasons on adult Picual olive cv.(8 years old) in a private orchard located at Cairo Ismailia Desert Road, (about 80 Km from Cairo), Governorate, Egypt.Trees are grown sandy soil, under drip irrigation system, uniform shape received the common horticultural practices, therefore, this work aims to effect of spraying different concentrations dates spray algae moringa leaf extract (MLE) for tow times vegetative growth, mineral contents, yield...

Radiation and chemotherapy are toxic agents; their clinical utility, nevertheless, curative effect restricted by side consequences such as nephrotoxicity. This study aims to determine the potential protective effects of Garcinol (G) (10 mg/kg/orally/daily for 4 weeks), a natural polyisoprenylated benzophenone, against renal injury in cyclophosphamide (CA) (150 mg/kg i.p. single-dose) and/or radiation (R) delivered fractionated doses 2 Gy/week up total cumulative dose 6 Gy induce toxicity...

Bisphenol A (BPA), a carbon-based synthetic polymer compound, was newly classified as an environmental toxicant and endocrine-disrupting chemical leading to abnormalities in cell proliferation, apoptosis, or migration that contributes cancer development progression. This study aims evaluate the effect of elevation γ- radiation dose BPA on liver ovaries female rats. In this study, eighty albino rats (130–150 g) were used work. Rats experiment received ethanol (50 mg/kg b. wt.) for 30 days,...

Gemcitabine (GEM) is a deoxycytidine analog chemotherapeutic drug widely used to treat many cancers. Silver nanoparticles (AgNPs) are important nanomaterials diseases. Using gamma radiation in nanoparticle preparation new eco-friendly method. This study aims evaluate the efficiency of co-treating gemcitabine and silver treating hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is one of the most fatal cancers around world and remain asymptomatic in early stage. An alcoholic extract prepared from leaves Tropaeolum majus L. (Tropaeolaceae) was assessed for its potential activity against diethylnitrosamine-induced liver vivo. Oral administration significantly decreased inflammatory marker translation NF-kB supressed HCC progression combination with 0.5 Gy gamma radiation via EGF-HER-2 pathway. Histopathological immunohistopathological...

This study aimed to observe the anticancer, as well radiosensitizing, effect of Anagallis arvensis extract (AAE) on growth breast cancer cells (BCCs). was evaluated through measured cell cycle arrest plus apoptosis flowcytometry analyses associated with a protein level estrogen receptors (ER-α and ER-β), Fork head box O3a (FOXO3), phosphorylated histone H2AX (γ-H2AX) by western blotting analysis. Further, gene expression mir-18, mir-101, mir-421, let-7 detected via real-time polymerase chain...

Background: Lung cancer remains the most common primary tumor responsible for brain metastases making up to 40% 50% of cases. Brain from NSCLC is associated with poor prognosis. Aim: The aim this study analyze risk factors and treatment outcome patients who developed metastases; identify which subgroup these better survival outcome. Methods: We analyzed all presented Kasralainy Center Clinical Oncology Nuclear Medicine (NEMROCK) during period between January 2006 December 2012. Seven hundred...

Field trials were carried out at the Experimental Research Station of Desert Center Ras Sudr , South Sinai Governorate during 2003 and 2004 seasons .This investigation aimed to improve tomato genotypes for salinity tolerance in SuperMarmand CastleRock marketable characters exotic LA1673 LA1963 Edkawy results indicated that was superior than other plant height, number fruits/ plant, locules / fruit total soluble solids under saline condition.While, two local Castle Rock earlier heavier...

For many decades the terrestrial plants are represent an infinitive source of bioactive substances as well pharmaceutical components which play a main role in discovering ,developing and manufacturing anticancer antibiotic drugs.Solenostemmaargel is desert plant widely used Arabic countries antispasmodic, anti-inflammatory anti-rheumatic agent. It also has anti-tumor activity. Aim: present study was oriented to investigatethe hepato-protective effect fermentedSolenostemmaargelleave extract...

Many studies reported the diverse therapeutic potential of essential oils. They have a crucial role in cancer prevention and treatment. Antioxidant, antimutagenic, antiproliferative are mechanisms involved. Also, oils may enhance immune function surveillance, induce enzymes, detoxification, modulate multidrug resistance. Hemp oil, obtained from Cannabis sativaL. seeds, is known for its health-enhancing properties bioactivity. Adult female Swiss albino mice were injected with viable Ehrlich...

Abstract Purpose Gemcitabine (GEM) is a deoxycytidine analog chemotherapeutic drug widely used for the treatment of many cancers. Silver nanoparticles (AgNPs) are important nanomaterials in diseases such as infectious diseases. Using gamma radiation nanoparticle preparation new eco-friendly method. This study aims to evaluate efficency co-treatment gemcitabine and silver hepatocellular carcinoma treatment. Methods AgNPs characterization has been done using UV- visible spectroscopy, XRD, TEM,...