Abstract Nattokinase (NK), a protease enzyme produced by Bacillus subtilis , has various biological effects such as lipid-lowering activity, antihypertensive, antiplatelet/anticoagulant, and neuroprotective effects. Exposure to environmental toxicants bisphenol A (BPA) or γ-radiation (IR) causes multi-organ toxicity through several mechanisms impairment of oxidative status, signaling pathways, hepatic neuronal functions well disruption the inflammatory responses. Therefore, this study is...

Hepatic encephalopathy (HE) is a syndrome that arises from acute or chronic liver failure. This study was devised to assess the impact of combination boswellic acid (BA) and low doses gamma radiation (LDR) on thioacetamide (TAA)-induced HE in an animal model. The effect daily BA treatment (175 mg/kg body weight, for four weeks) and/or fractionated low-dose γ-radiation (LDR; 0.25 Gy, twice total dose 0.5 Gy) evaluated against TAA (200 mg/kg, intraperitoneal) twice-weekly weeks induce damage...

Background: Acute myocardial necrosis, or infarction (MI), is the most deadly form of coronary artery disease (CAD), which typically occurs when blood flow to a portion heart stops, damaging muscles. The synthetic nonselective β-adrenergic agonist isoproterenol known cause cardiac conditions like energy depletion, hypotension, oxidative stress, and calcium overload. Hemorrhoids, diabetes, muscle spasms, chronic inflammation, cardiovascular disorders, Alzheimer's disease, stroke, other can...

This study aimed to evaluate the antitumor activity of platinum nanoparticles compared with cis-platin both in vitro and vivo treatment hepatocellular carcinoma induced rats. The efficacy was evaluated by measuring antioxidant activities against oxidative stress caused diethylnitrosamine liver tissue. measurements included reduced glutathione content superoxide dismutase activity, as well malondialdehyde level. Liver function tests were also determined, addition evaluation serum...

Nonalcoholic fatty liver disease (NAFLD) is a major health concern. Endoplasmic reticulum (ER) stress, inflammation, and metabolic dysfunctions may be targeted to prevent the progress of nonalcoholic disease. Sulforaphane (SFN), sulfur-containing compound that abundant in broccoli florets, seeds, sprouts, has been reported have beneficial effects on attenuating diseases. In light this, present study was designed elucidate mechanisms by which SFN ameliorated ER lipid metabolism, insulin...

Interstitial pulmonary fibrosis is characterized by an altered cellular composition of the alveolar region with excessive deposition collagen. Lung inflammation also common in fibrosis. This study aims to test inhibition 5-lipooxygenase (5-LOX) boswellic acid (BA) extract experimental model using bleomycin (BL).Boswellic (1 g/kg) was force-fed rats seven days prior administration BL or gamma irradiation both. (0.15 U/rat) 25 μl 0.9% normal saline (NS) NS alone administered intratracheally....

Liver injury due to ionizing radiation exposure either accidental or after radiotherapy treatment, may lead many alterations in proteins expression related inflammation apoptosis. Our study investigated the curative effect of Mangosteen (MGS) extract (fruit rind) against (IR) induced liver damage.Hepatotoxicity was Wister rats by an acute single dose (6 Gy) IR while MGS given orally (500 mg/kg bwt) and administered daily for 30 days irradiation.MGS treatment has significantly attenuated...

Improving radiation effect on tumor cells using radiosensitizers is gaining traction for improving chemoradiotherapy. This study aimed to evaluate copper nanoparticles (CuNPs) synthesized chrysin as radiosensitizer with γ-radiation biochemical and histopathological approaches in mice bearing Ehrlich solid tumor. CuNPs were characterized irregular round sharp shape size range of 21.19-70.79 nm plasmon absorption at 273 nm. In vitro MCF-7 detected cytotoxic IC50 57.2 ± 3.1 μg. vivo was...

Combining chemotherapy with radiotherapy potentiates the outcome of cancer treatment for more comprehensive attack. In current study, we continued to assess therapeutic efficaciousness newly synthesized gallium nanoparticles (GaNPs) combined low level gamma radiation (IR), on incidence diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats. Oral administration GaNPs (1 mg/Kg b.wt.) 5 times per week 6 weeks IR rats treated DEN (20 b.wt. weeks) significantly reduced serum...

A major biomarker for liver fibrosis is transglutaminase which catalyzes cross-linking of epsilon-amines and alpha-glutamyl residues among amino acids leading to fibrosis. Fructus Piperis Longi a common herb used in Chinese medicine. The present study evaluates the role ethanol extract modulation function Plf (50 mg/kg) was force-fed rats every other day 7 days before administration thioacetamide and/or gamma irradiation. Thioacetamid 200 mg/kg intraperitoneally administered twice per week...

Cancer stem cells (CSCs) are implicated in the genesis, development, and recurrence of lung cancer (LC) with great resistance to radiation chemotherapy. The aim this study is assess inhibitory potential ethanol extract Withania somnifera (WS); 500 mg/kg body-weight/day 8 Gy ionizing (IR) could inhibit stemness gene confer radiosensitizing effect W. female rat LC model. Compared IR or WS, vitro assay showed that WS + potentiates proliferation-inhibition cell death A-549 line suppresses sphere...

Introduction: In the fight against cancer, cisplatin is most widely used as a clinical mainstay for chemotherapy of various human cancers. Meanwhile, its cytotoxic profile, well drug resistance, limits widespread application. The goal precision medicine to tailor an optimized therapeutic program based on biology disease. Recently, nanotechnology has been demonstrated be promising in this scenario. Objective: current work provides rationale design alternative oncology trial treatment...

With the rapidly expanding applications of artificial intelligence (AI), quest for hardware acceleration to foster high-speed and energy-efficient AI computation has become ever more important. In this work, we first explore performance energy advantages employing classical with conventional systolic multiply-accumulate (MAC) arrays. We then highlight growing importance monolithic 3D integration as a transformative strategy, moving beyond constraints von Neumann architectures. also discuss...

Radiation and chemotherapy are toxic agents; their clinical utility, nevertheless, curative effect restricted by side consequences such as nephrotoxicity. This study aims to determine the potential protective effects of Garcinol (G) (10 mg/kg/orally/daily for 4 weeks), a natural polyisoprenylated benzophenone, against renal injury in cyclophosphamide (CA) (150 mg/kg i.p. single-dose) and/or radiation (R) delivered fractionated doses 2 Gy/week up total cumulative dose 6 Gy induce toxicity...

Although ionizing radiation (IR) has been of immense value to human life due its involvement in several fields, it doesn't eliminate that exposure IR results an array biological consequences, including oxidative stress, inflammation, and death. Thus, this study aimed explore the curative effect trans-Resveratrol (t-Res) on hepatic renal injury a rat model exposed single fractionated doses γ-rays.Rats dose (6 Gy, as acute effect) or (2 Gy/time/3 days, day after day; imitate chronic impact)...

Bisphenol A (BPA), a carbon-based synthetic polymer compound, was newly classified as an environmental toxicant and endocrine-disrupting chemical leading to abnormalities in cell proliferation, apoptosis, or migration that contributes cancer development progression. This study aims evaluate the effect of elevation γ- radiation dose BPA on liver ovaries female rats. In this study, eighty albino rats (130–150 g) were used work. Rats experiment received ethanol (50 mg/kg b. wt.) for 30 days,...

The present study was designed to elucidate the protective effect of subsequent pretreatment with Fructus Piperis Longi extract in liver and brain tissue experimental rats exposed Hepatic encephalopathy induced by intraperitoneal administration TAA.Plf (50 mg/kg) force-fed every day, 7 days before Thioacetamide.Thioacetamide 200 mg/kg intraperitoneally administered twice per week for four weeks.Administration Plfext extended during Thioacetamide.After 4 weeks, animals were...