A5048066802- Immune Cell Function and Interaction
- Global Maternal and Child Health
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
- Salmonella and Campylobacter epidemiology
- Parasites and Host Interactions
- Mycobacterium research and diagnosis
- Pregnancy and preeclampsia studies
- Hepatitis Viruses Studies and Epidemiology
- Blood donation and transfusion practices
- Hemoglobinopathies and Related Disorders
- Blood groups and transfusion
- Influenza Virus Research Studies
- Ethnobotanical and Medicinal Plants Studies
- Malaria Research and Control
- Complement system in diseases
- Renal Transplantation Outcomes and Treatments
- Pharmacology and Nanomedicine Research
- Child Nutrition and Water Access
- Global Health Workforce Issues
- Parasite Biology and Host Interactions
- SARS-CoV-2 and COVID-19 Research
- Moringa oleifera research and applications
- Global Health and Surgery
Technical University of Mombasa
2015-2024
Huazhong University of Science and Technology
2014-2017
University of Science and Technology
2015
State Key Laboratory of Virology
2007-2012
Wuhan University
2007-2008
Zhongnan Hospital of Wuhan University
2007
L-ficolin, one of the complement lectins found in human serum, is a novel pattern recognition molecule that can specifically bind to microbial carbohydrates, thereby activating lectin pathway and mounting protective innate immune response. However, little known about role L-ficolin during viral infections vivo. In present study, we used mouse model influenza A virus infection demonstrate administration exogenous or ficolin (FCNA - an L-ficolin-like mouse) against virus. Furthermore,...
Background Prevalence of malaria in pregnancy (MiP) Kenya ranges from 9% to 18%. We estimated the prevalence and factors associated with MiP anemia (AiP) among asymptomatic women attending antenatal care (ANC) visits. Methods performed a cross-sectional study pregnant ANC at Msambweni Hospital, between September 2018 February 2019. Data was collected analyzed Epi Info 7. Descriptive statistics were calculated we compared AiP cases those without either condition. Adjusted Odds odds ratios...
Schistosoma haematobium, soil transmitted helminthes (STH), and malaria lead to a double burden in pregnancy that eventually leads poor immunity, increased susceptibility other infections, outcomes. Many studies have been carried out on pre-school school aged children but very little has done among the at risk adult population including women of reproductive age (WRA). Our current study sought establish factors co-infection with S. STH, Plasmodium sp. WRA Kwale County, Coastal Kenya.
Attenuated Salmonella enterica serovar Typhi strains have been considered to be attractive as potential live oral delivery vector vaccines because of their ability elicit the full array immune responses in humans. In this study, we constructed an attenuated S. strain stably expressing conserved nucleocapsid (N) protein severe acute respiratory syndrome-associated coronavirus (SARS-CoV) by integrating N gene into pilV gene, which was under control type IVB pilus operon promoter Typhi. BALB/c...
Introduction: alloreactive tumor specific T cells are important arsenals of the adaptive immune system in fight against tumors. However, stem cell-like memory (Tscm) provide key to effective elimination cells. Methods for generating these cell subsets already exist. they could be made more efficient. Further, expensive and unattainable resource poor laboratories. In this regard, we hereby describing a novel vitro allogeneic co-culture method raising allo-restricted Tscm that developed.
CD8(+) suppressor T cells have been demonstrated to provide protection of allografts from rejection. We previously reported that soluble peptide/HLA-A2 dimer shows peptide-specific inhibitory effects on alloresponse in a coculture peptide-pulsed T2 with HLA-A2 negative lymphocytes vitro. Here we found subset CD8(low)CD28(-) was induced the dimer-treated coculture. Importantly, this population showed hyporesponsiveness alloantigen restimulation as well alloantigen-specific suppression...
Introduction: urogenital schistosomiasis is one of the neglected tropical diseases common in developing countries. It thirteen most chronic infections that affect poor people many characterized by limited knowledge mode transmission, negative social repercussions, and high morbidity which result manifestation this infection female population. This qualitative cross-sectional study assessed levels, attitudes, practices about women reproductive age (WRA), rural, resource-poor communities Kwale...
Soil transmitted helminthiasis (STH), Schistosoma haematobium and malaria co-infection lead to increased susceptibility other infections poor pregnancy outcomes among women of reproductive age (WRA). This study sought establish risk factors, burden with STH, S . Plasmodium sp. WRA in Kilifi County, Kenya.A mixed method cross-sectional was conducted on 474 2021. Simple random sampling used select from four villages two purposively sampled sub-counties. Study participants were interviewed,...
During transfusion, components of blood including red cells, platelets and plasma are directly administered into the recipient to treat conditions such as anaemia haemostatic deficiencies. In most cases, effective transfusions will positively impact patient prognosis. Red cell abnormalities greatly on effectiveness transfusion. This is because efficacy a unit depends amount delivered, quality cells life span given unit. The aim this study was establish occurrence in donor blood. descriptive...
Organ transplantation offers hope to a variety of patients with terminal functioning organs and tissues. This is currently made possible by administration general immunosuppressive drugs. To date, inducing tolerance allografts has become the holy grail every immunologist. In effect, there been great deal research aiming come up alternative therapeutic mechanisms that would allow one do away or reduce amount drugs used either at induction, maintenance, both phases. It shown in recent years...
Currently, general immunosuppressive drugs are used to maintain tolerance allografts. However, these have a major drawback of rendering the patient susceptible infections and other side effects like malignancy drug related toxicities with an overall rejection organ at some point. Previous studies shown that MHC-Ig dimers may suppress alloresponsive T cells in donor specific manner vitro. This work aimed answer question as whether will surmount through direct mechanism allorecognition by...
Infectious diseases are the main causes of morbidity and mortality worldwide. There is increasing concern indiscriminate use antibiotics incidences multiple antibiotic resistances in human pathogens. The potential higher plants as source new drug leads has been demonstrated but still under explored. In Africa most developing countries, traditional medicine forms backbone rural medicinal practice. Although a number American Asian countries herbs have evaluated scientifically their properties...